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Hypoxia-inducible Expression of Tumor-associated Carbonic -Anhydrases
Title Hypoxia-inducible Expression of Tumor-associated Carbonic -Anhydrases Author Wykoff Charles C. Co-authors Beasley N.J. Watson P.H. Campo L. Chia S.K. English R. Pastorek Jaromír 1957- SAVVIR - Virologický ústav SAV Sly W.S. Ratcliffe P. Harris Adrian L. Source document Cancer Research. Vol. 60 (2000), p. 7075-7083. - Birmingham : Amer.Assoc.Cancer Research Language eng - English Document kind rozpis článkov z periodík (rbx) Citations Wilson JF Hot papers - Understanding the VHL tumor suppressor complex - Comment SCIENTIST Volume: 15 Issue: 9 Pages: 20-21 Published: APR 30 2001 Phillips, J.L., Pavlovich, C.P., Walther, M., Ried, T., Linehan, W.M. The genetic basis of renal epithelial tumors: Advances in research and its impact on prognosis and therapy Current Opinion in Urology 11 (5), pp. 463-469 , 2001 Semenza, G.L. Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology Trends in Molecular Medicine 7 (8), pp. 345-350 , 2001 Lal, A.a , Peters, H.d , St. Croix, B.e , Haroon, Z.A.b , Dewhirst, M.W.b , Strausberg, R.L.f , Kaanders, J.H.A.M.d , Van Der Kogel, A.J.d , Riggins, G.J. Transcriptional response to hypoxia in human tumors Journal of the National Cancer Institute 93 (17), pp. 1337-1343 , 2001 Uemura, H. MN/CA9 Novel Biomarker for Renal Cell Carcinoma Japanese Journal of Clinical Urology 55 (5), pp. 329-335 , 2001 Huang, G.Y., Yang, L.Y Molecular mechanism of malignant transferring of tumors dus to lack of oxygen World Chinese Journal of Digestology 9 (11), pp. 1300-1304 , 2001 Nakagawa, Y., Uemura, H., Shimizu, K., Cho, M., Yoshikawa, M., Hirao, Y., Yoshikawa, K. The role of MN/CA IX antigen in carcinogenesis and metastasis of renal cell carcinoma Acta Urologica Japonica 47 (11), pp. 809-814 , 2001 Toi, M., Bando, Y., Saji, S., Matsumoto, T. Tumor angiogenesis and hypoxia Biotherapy 15 (6), pp. 663-668 , 2001 Semenza GL Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology TRENDS IN MOLECULAR MEDICINE Volume: 7 Issue: 8 Pages: 345-350 Published: AUG 2001 Lal A, Peters H, St Croix B, Haroon ZA, Dewhirst MW, Strausberg RL, Kaanders JHAM, van der Kogel AJ, Riggins GJ Transcriptional response to hypoxia in human tumors JOURNAL OF THE NATIONAL CANCER INSTITUTE Volume: 93 Issue: 17 Pages: 1337-1343 Published: SEP 5 2001 Camenisch G, Stroka DM, Gassmann M, Wenger RH Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY Volume: 443 Issue: 2 Pages: 240-249 Published: NOV 2001 Olive PL, Aquino-Parsons C, MacPhail SH, Liao SY, Raleigh JA, Lerman MI, Stanbridge EJ Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer CANCER RESEARCH Volume: 61 Issue: 24 Pages: 8924-8929 Published: DEC 15 2001 Begg AC, Janssen H, Sprong D, Hofland I, Blommestijn G, Raleigh JA, Varia M, Balm A, van Velthuyzen L, Delaere P, Sciot R, Haustermans KMG Hypoxia and perfusion measurements in human tumors - Initial experience with Pimonidazole and IUdR ACTA ONCOLOGICA Volume: 40 Issue: 8 Pages: 924-928 Published: 2001 Olive PL, Banath JP, Aquino-Parsons C Measuring hypoxia in solid tumours - Is there a gold standard? 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JOURNAL OF CLINICAL ONCOLOGY Volume: 20 Issue: 3 Pages: 610-615 Published: FEB 1 2002 Koukourakis MI Amifostine in clinical oncology: current use and future applications ANTI-CANCER DRUGS Volume: 13 Issue: 3 Pages: 181-209 Published: MAR 2002 Wiesener MS, Seyfarth M, Warnecke C, Jurgensen JS, Rosenberger C, Morgan NV, Maher ER, Frei U, Eckardt KU Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel-Lindau gene in a renal cell carcinoma BLOOD Volume: 99 Issue: 10 Pages: 3562-3565 Published: MAY 15 2002 McNally VA, Patterson AV, Williams KJ, Cowen RL, Stratford IJ, Jaffar M Antiangiogenic, bioreductive and gene therapy approaches to the treatment of hypoxic tumours CURRENT PHARMACEUTICAL DESIGN Volume: 8 Issue: 15 Pages: 1319-1333 Published: 2002 Wenger RH Cellular adaptation to hypoxia: O-2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O-2-regulated gene expression FASEB JOURNAL Volume: 16 Issue: 10 Published: AUG 2002 Semenza GL Signal transduction to hypoxia-inducible factor 1 Conference Information: Meeting on Cell Signaling Transcription and Translation as Therapeutic Targets, JAN 30-FEB 02, 2002 Swinson DEB, Jones JL, Richardson D, Cox G, Edwards JG, O'Byrne KJ Tumour necrosis is an independent prognostic marker in non-small cell lung cancer: correlation with biological variables LUNG CANCER Volume: 37 Issue: 3 Pages: 235-240 Published: SEP 2002 Acker T, Plate KH A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology JOURNAL OF MOLECULAR MEDICINE-JMM Volume: 80 Issue: 9 Pages: 562-575 Published: SEP 2002 Yao M, Yoshida M, Kishida T, Nakaigawa N, Baba M, Kobayashi K, Miura T, Moriyama M, Nagashima Y, Nakatani Y, Kubota Y, Kondo K VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma JOURNAL OF THE NATIONAL CANCER INSTITUTE Volume: 94 Issue: 20 Pages: 1569-1575 Published: OCT 16 2002 Ashida S, Nishimori I, Tanimura M, Onishi S, Shuin T Effects of von Hippel-Lindau gene mutation and methylation status on expression of transmembrane carbonic anhydrases in renal cell carcinoma JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY Volume: 128 Issue: 10 Pages: 561-568 Published: OCT 2002 Kaanders JHAM, Wijffels KIEM, Marres HAM, Ljungkvist ASE, Pop LAM, van den Hoogen FJA, de Wilde PCM, Bussink J, Raleigh JA, van der Kogel AJ Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer CANCER RESEARCH Volume: 62 Issue: 23 Pages: 7066-7074 Published: DEC 1 2002 Pollard, P.J., Wortham, N.C., Tomlinson, I.P.M The TCA cycle and tumorigenesis: The examples of fumarate hydratase and succinate dehydrogenase Annals of Medicine 35 (8), pp. 632-639 , 2003 Kaluz, S., Kaluzová, M., Stanbridge, E.J. Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer Cancer Research 63 (5), pp. 917-922 ,2003 Richard, S. von Hippel-Lindau disease: Recent advances and therapeutic perspectives Expert Review of Anticancer Therapy 3 (2), pp. 215-233 , 2003 Höpfl, G., Ogunshola, O., Gassmann, M. Hypoxia and high altitude: The molecular response Advances in Experimental Medicine and Biology 543, pp. 89-115 , 2003 Welsh, S.J., Powis, G. Hypoxia Inducible Factor as a Cancer Drug Target Current Cancer Drug Targets 3 (6), pp. 391-405 , 2003 Bui MHT, Seligson D, Han KR, Pantuck AJ, Dorey FJ, Huang Y, Horvath S, Leibovich BC, Chopra S, Liao SY, Stanbridge E, Lerman MI, Palotie A, Figlin RA, Belldegrun AS Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: Implications for prognosis and therapy CLINICAL CANCER RESEARCH Volume: 9 Issue: 2 Pages: 802-811 Published: FEB 2003 Sonna LA, Cullivan ML, Sheldon HK, Pratt RE, Lilly CM Effect of hypoxia on gene expression by human hepatocytes (HepG2) PHYSIOLOGICAL GENOMICS Volume: 12 Issue: 3 Pages: 195-207 Published: FEB 6 2003 Brown JM Tumor microenvironment and the response to anticancer therapy CANCER BIOLOGY & THERAPY Volume: 1 Issue: 5 Pages: 453-458 Published: SEP-OCT 2002 Lando D, Gorman JJ, Whitelaw ML, Peet DJ Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation EUROPEAN JOURNAL OF BIOCHEMISTRY Volume: 270 Issue: 5 Pages: 781-790 Published: MAR 2003 Kuwai T, Kitadai Y, Tanaka S, Onogawa S, Matsutani N, Kaio E, Ito M, Chayama K Expression of hypoxia-inducible factor-l alpha is associated with tumor vascularization in human colorectal carcinoma INTERNATIONAL JOURNAL OF CANCER Volume: 105 Issue: 2 Pages: 176-181 Published: JUN 10 2003 Warnecke C, Griethe W, Weidemann A, Jurgensen JS, Willam C, Bachmann S, Ivashchenko Y, Wagner I, Frei U, Wiesener M, Eckardt KU Activation of the hypoxia-inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors FASEB JOURNAL Volume: 17 Issue: 6 Pages: 1186-+ Published: APR 2003 Hernandez JM, Bui MHT, Han KR, Mukouyama H, Freitas DG, Nguyen D, Caliliw R, Shintaku PI, Paik SH, Tso CL, Figlin RA, Belldegrun AS Novel kidney cancer immunotherapy based on the granulocyte-macrophage colony-stimulating factor and carbonic anhydrase IX fusion gene CLINICAL CANCER RESEARCH Volume: 9 Issue: 5 Pages: 1906-1916 Published: MAY 2003 Winum JY, Vullo D, Casini A, Montero JL, Scozzafava A, Supuran CT Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors JOURNAL OF MEDICINAL CHEMISTRY Volume: 46 Issue: 11 Pages: 2197-2204 Published: MAY 22 2003 Takahashi R, Tanaka S, Hiyama T, Masanoriito, Kitadai Y, Sumii M, Haruma K, Chayama K Hypoxia-inducible factor-1 alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach ONCOLOGY REPORTS Volume: 10 Issue: 4 Pages: 797-802 Published: JUL-AUG 2003 Bussink J, Kaanders JHAM, van der Kogel AJ Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers RADIOTHERAPY AND ONCOLOGY Volume: 67 Issue: 1 Pages: 3-15 Published: APR 2003 Ho YT, Purohit A, Vicker N, Newman SP, Robinson JJ, Leese MP, Ganeshapillai D, Woo LWL, Potter BVL, Reed MJ Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Volume: 305 Issue: 4 Pages: 909-914 Published: JUN 13 2003 Evans SM, Koch CJ Prognostic significance of tumor oxygenation in humans CANCER LETTERS Volume: 195 Issue: 1 Pages: 1-16 Published: MAY 30 2003 Span PN, Bussink J, Manders P, Beex LVAM, Sweep CGJ Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome BRITISH JOURNAL OF CANCER Volume: 89 Issue: 2 Pages: 271-276 Published: JUL 21 2003 Bracken CP, Whitelaw ML, Peet DJ The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses CELLULAR AND MOLECULAR LIFE SCIENCES Volume: 60 Issue: 7 Pages: 1376-1393 Published: JUL 2003 Barber PR, Vojnovic B, Atkin G, Daley FM, Everett SA, Wilson GD, Gilbey JD Applications of cost-effective spectral imaging microscopy in cancer research JOURNAL OF PHYSICS D-APPLIED PHYSICS Volume: 36 Issue: 14 Pages: 1729-1738 Published: JUL 21 2003 Shannon AM, Bouchier-Hayes DJ, Condron CM, Toomey D Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies CANCER TREATMENT REVIEWS Volume: 29 Issue: 4 Pages: 297-307 Published: AUG 2003 Chrastina A High cell density-mediated pericellular hypoxia is a crucial factor inducing expression of the intrinsic hypoxia marker CA IX in vitro in HeLa cells NEOPLASMA Volume: 50 Issue: 4 Pages: 251-256 Published: 2003 Hoskin PJ, Sibtain A, Daley FM, Wilson GD GLUTI and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON BRITISH JOURNAL OF CANCER Volume: 89 Issue: 7 Pages: 1290-1297 Published: OCT 6 2003 Shiao YH The von Hippel-Lindau gene and protein in tumorigenesis and angiogenesis: A potential target for therapeutic designs CURRENT MEDICINAL CHEMISTRY Volume: 10 Issue: 22 Pages: 2461-2470 Published: NOV 2003 Maxwell P HIF-1: An oxygen response system with special relevance to the kidney JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 14 Issue: 11 Pages: 2712-2722 Published: NOV 2003 Azuma Y, Chou SC, Lininger RA, Murphy BJ, Varia MA, Raleigh JA Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: Pimonidazole and involucrin CLINICAL CANCER RESEARCH Volume: 9 Issue: 13 Pages: 4944-4952 Published: OCT 15 2003 Pantuck AJ, Zeng G, Belldegrun AS, Figlin RA Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: Exploiting the hypoxia-induced pathway CLINICAL CANCER RESEARCH Volume: 9 Issue: 13 Pages: 4641-4652 Published: OCT 15 2003 Greco O, Marples B, Joiner MC, Scott SD How to overcome (and exploit) tumor hypoxia for targeted gene therapy JOURNAL OF CELLULAR PHYSIOLOGY Volume: 197 Issue: 3 Pages: 312-325 Published: DEC 2003 Hedley D, Pintilie M, Woo J, Morrison A, Birle D, Fyles A, Milosevic M, Hill R Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas CLINICAL CANCER RESEARCH Volume: 9 Issue: 15 Pages: 5666-5674 Published: NOV 15 2003 Winum JY, Vullo D, Casini A, Montero JL, Scozzafava A, Supuran CT Carbonic anhydrase inhibitors: Inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic Isozymes I and II with aliphatic sulfamates JOURNAL OF MEDICINAL CHEMISTRY Volume: 46 Issue: 25 Pages: 5471-5477 Published: DEC 4 2003 Vordermark D, Brown JM Endogenous markers of tumor hypoxia - Predictors of clinical radiation resistance? 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Selective inhibition of human tumor-associated isozymes IX and XII and cytosolic isozymes I and II with some substituted-2-mercapto-benzenesulfonamides JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 21 (5): 563-568 OCT 2006 Yap TA, Eisen TG Adjuvant therapy of renal cell carcinoma CLINICAL GENITOURINARY CANCER 5 (2): 120-130 SEP 2006 Shintani K (Shintani, Ken), Matsumine A (Matsumine, Akihiko), Kusuzaki K (Kusuzaki, Katsuyuki), Matsubara T (Matsubara, Takao), Satonaka H (Satonaka, Haruhiko), Wakabayashi T (Wakabayashi, Toru), Hoki Y (Hoki, Yoko), Uchida A (Uchida, Atsumasa) Expression of hypoxia-inducible factor (HIF)-1 alpha as a biomarker of outcome in soft-tissue sarcomas VIRCHOWS ARCHIV 449 (6): 673-681 DEC 2006 Kon-No H (Kon-no, Hidehiro), Ishii G (Ishii, Genichiro), Nagai K (Nagai, Kanji), Yoshida J (Yoshida, Junji), Nishimura M (Nishimura, Mitsuyo), Nara M (Nara, Michiya), Fujii T (Fujii, Tomoki), Murata Y (Murata, Yukinori), Miyamoto H (Miyamoto, Hideaki), Ochiai A (Ochiai, Atsushi) Carbonic anhydrase IX expression is associated with tumor progression and a poor prognosis of lung adenocarcinoma LUNG CANCER 54 (3): 409-418 DEC 2006 Thiry A (Thiry, Anne), Dogne JM (Dogne, Jean-Michel), Masereel B (Masereel, Bernard), Supuran CT (Supuran, Claudiu T.) Targeting tumor-associated carbonic anhydrase IX in cancer therapy TRENDS IN PHARMACOLOGICAL SCIENCES 27 (11): 566-573 NOV 2006 Brennan DJ (Brennan, Donal J.), Jirstrom K (Jirstrom, Karin), Kronblad A (Kronblad, Asa), Millikan RC (Millikan, Robert C.), Landberg G (Landberg, Goran), Duffy MJ (Duffy, Michael J.), Ryden L (Ryden, Lisa), Gallagher WM (Gallagher, William M.), O'Brien SL (O'Brien, Sallyann L.) CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance CLINICAL CANCER RESEARCH 12 (21): 6421-6431 NOV 1 2006 Swinson DEB, O'Byrne KJ Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer CLINICAL LUNG CANCER 7 (4): 250-256 JAN 2006 Ke QD (Ke, Qingdong), Costa M (Costa, Max) Hypoxia-inducible factor-1 (HIF-1) MOLECULAR PHARMACOLOGY 70 (5): 1469-1480 NOV 2006 Atkin GK (Atkin, G. K.), Daley FM (Daley, F. 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Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16 (18): 4846-4851 SEP 15 2006 De Simone G (De Simone, Giuseppina), Vitale RM (Vitale, Rosa Maria), Di Fiore A (Di Fiore, Anna), Pedone C (Pedone, Carlo), Scozzafava A (Scozzafava, Andrea), Montero JL (Montero, Jean-Louis), Winum JY (Winum, Jean-Yves), Supuran CT (Supuran, Claudiu T.) Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX JOURNAL OF MEDICINAL CHEMISTRY 49 (18): 5544-5551 SEP 7 2006 Jonathan RA (Jonathan, Ruth A.), Wijffels KIEM (Wijffels, Karien I. E. M.), Peeters W (Peeters, Wenny), de Wilde PCM (de Wilde, Peter C. M.), Marres HAM (Marres, Henri A. M.), Merkx MAW (Merkx, Matthias A. 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Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses JOURNAL OF BIOLOGICAL CHEMISTRY 281 (30): 20993-21003 JUL 28 2006 Yanase S (Yanase, Sigeaki), Nomura J (Nomura, Jouji), Matsumura Y (Matsumura, Yoshihiko), Nagata T (Nagata, Takayuki), Fujii T (Fujii, Tasuku), Tagawa T (Tagawa, Toshiro) Synergistic interaction of 5-aminolevulinic acid-based photodynamic therapy with simultaneous hyperthermia in an osteosarcoma tumor model INTERNATIONAL JOURNAL OF ONCOLOGY 29 (2): 365-373 AUG 2006 Fisher SZ, Govindasamy L, Boyle N, Agbandje-McKenna M, Silverman DN, Blackburn GM, McKenna R X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 62: 618-622 Part 7, JUL 2006 Yuan H, Schroeder T, Bowsher JE, Hedlund LW, Wong T, Dewhirst MW Intertumoral differences in hypoxia selectivity of the PET imaging agent Cu-64(II)-diacetyl-bis(N-4-methylthiosemicarbazone) JOURNAL OF NUCLEAR MEDICINE 47 (6): 989-998 JUN 2006 Goethals L, Debucquoy A, Perneel C, Geboes K, Ectors N, De Schutter H, Penninckx F, McBide WH, Begg AC, Haustermans KM Hypoxia in human colorectal adenocarcinoma: Comparison between extrinsic and potential intrinsic hypoxia markers INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 65 (1): 246-254 MAY 1 2006 Thiry A, Ledecq M, Cecchi A, Dogne JM, Wouters J, Supuran CT, Masereel B Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX JOURNAL OF MEDICINAL CHEMISTRY 49 (9): 2743-2749 MAY 4 2006 Lam JS, Belldegrun AS, Figlin RA Adjuvant treatment for renal cell carcinoma EXPERT OPINION ON PHARMACOTHERAPY 7 (6): 705-720 APR 2006 Dayan F, Roux D, Brahimi-Horn MC, Pouyssegur J, Mazure NM The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-alpha CANCER RESEARCH 66 (7): 3688-3698 APR 1 2006 Patard JJ, Rioux-Leclercq N, Fergelot P Understanding the importance of smart drugs in renal cell carcinoma EUROPEAN UROLOGY 49 (4): 633-643 APR 2006 van Laarhoven HWM, Kaanders JHAM, Lok J, Peeters WJM, Rijken PFJW, Wiering B, Ruers TJM, Punt CJA, Heerschap A, van der Kogel AJ Hypoxia in relation to vasculature and proliferation in liver metastases in patients with colorectal cancer INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 64 (2): 473-482 FEB 1 2006 Brown LM, Cowen RL, Debray C, Eustace A, Erler JT, Sheppard FCD, Parker CA, Stratford IJ, Williams KJ Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1 MOLECULAR PHARMACOLOGY 69 (2): 411-418 FEB 2006 Kaluz S, Kaluzova M, Stanbridge EJ The role of extracellular signal-regulated protein kinase in transcriptional regulation of the hypoxia marker carbonic anhydrase IX JOURNAL OF CELLULAR BIOCHEMISTRY 97 (1): 207-216 JAN 1 2006 Willam C, Warnecke C, Schefold JC, Kugler J, Koehne P, Frei U, Wiesener M, Eckardt KU Inconsistent effects of acidosis on HIF-alpha protein and its target genes PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 451 (4): 534-543 JAN 2006 Corn, P.G. 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Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms BRITISH JOURNAL OF CANCER, 96 (8): 1284-1292 APR 23 2007 Fumoleau, P (Fumoleau, Pierre); Coudert, B (Coudert, Bruno); Mayer, F (Mayer, Francoise); Isambert, N (Isambert, Nicolas); Favier, L (Favier, Laure); Ferrant, E (Ferrant, Emmanuelle) Angiogenesis targeting in breast cancer BULLETIN DU CANCER, 94: F199-F206 Suppl. 7 SEP 2007 Di Cristofano, C (Di Cristofano, Claudio); Minervini, A (Minervini, Andrea); Menicagli, M (Menicagli, Michele); Salinitri, G (Salinitri, Giuseppe); Bertacca, G (Bertacca, Gloria); Pefanis, G (Pefanis, Gerasimos); Masieri, L (Masieri, Lorenzo); Lessi, F (Lessi, Francesca); Collecchi, P (Collecchi, Paola); Minervini, R (Minervini, Riccardo); Carini, M (Carini, Marco); Bevilacqua, G (Bevilacqua, Generoso); Cavazzana, A (Cavazzana, Andrea) Nuclear expression of hypoxia-inducible factor-1 alpha in clear cell renal cell carcinoma is involved in tumor progression AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 31 (12): 1875-1881 DEC 2007 Sherwood, BT (Sherwood, B. 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A multivariate survival study with emphasis upon carbonic anhydrase IX HUMAN PATHOLOGY, 38 (4): 629-638 APR 2007 Wilkinson, BL (Wilkinson, Brendan L.); Bornaghi, LF (Bornaghi, Laurent F.); Houston, TA (Houston, Todd A.); Innocenti, A (Innocenti, Alessio); Vullo, D (Vullo, Daniela); Supuran, CT (Supuran, Claudiu T.); Poulsen, SA (Poulsen, Sally-Ann) Carbonic anhydrase inhibitors: Inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides JOURNAL OF MEDICINAL CHEMISTRY, 50 (7): 1651-1657 APR 5 2007 Mabjeesh NJ, Amir S Hypoxia-inducible factor (HIF) in human tumorigenesis HISTOLOGY AND HISTOPATHOLOGY Volume: 22 Issue: 5 Pages: 559-572 Published: MAY 2007 Nuti, E (Nuti, Elisa); Orlandini, E (Orlandini, Elisabetta); Nencetti, S (Nencetti, Susanna); Rossello, A (Rossello, Armando); Innocenti, A (Innocenti, Alessio); Scozzafava, A (Scozzafava, Andrea); Supuran, CT (Supuran, Claudiu T.) Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates BIOORGANIC & MEDICINAL CHEMISTRY, 15 (6): 2298-2311 MAR 15 2007 Harvey AJ The role of oxygen in ruminant preimplantation embryo development and metabolism ANIMAL REPRODUCTION SCIENCE Volume: 98 Issue: 1-2 Pages: 113-128 Published: MAR 2007 Wilkinson, BL (Wilkinson, Brendan L.); Bornaghi, LF (Bornaghi, Laurent F.); Houston, TA (Houston, Todd A.); Innocenti, A (Innocenti, Alessio); Vullo, D (Vullo, Daniela); Supuran, CT (Supuran, Claudiu T.); Poulsen, SA (Poulsen, Sally-Ann) Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17 (4): 987-992 FEB 15 2007 Nishimori, I (Nishimori, Isao); Innocenti, A (Innocenti, Alessio); Vullo, D (Vullo, Daniela); Scozzafava, A (Scozzafava, Andrea); Supuran, CT (Supuran, Claudiu T.) Carbonic anhydrase inhibitors. 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DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors JOURNAL OF MEDICINAL CHEMISTRY, 50 (2): 381-388 JAN 25 2007 Diez, H (Diez, Holger); Fischer, A (Fischer, Andreas); Winkler, A (Winkler, Anja); Hu, CJ (Hu, Cheng-Jun); Hatzopoulos, AK (Hatzopoulos, Antonis K.); Breier, G (Breier, Georg); Gessler, M (Gessler, Manfred) Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate EXPERIMENTAL CELL RESEARCH, 313 (1): 1-9 JAN 1 2007 Yoo, H (Yoo, Heon); Baia, GS (Baia, Gilson S.); Smith, JS (Smith, Justin S.); McDermott, MW (McDermott, Michael W.); Bollen, AW (Bollen, Andrew W.); Berg, SRV (Berg, Scott R. Vanden); Lamborn, KR (Lamborn, Kathleen R.); Lal, A (Lal, Anita Expression of the hypoxia marker carbonic anhydrase 9 is associated with anaplastic phenotypes in meningiomas CLINICAL CANCER RESEARCH, 13 (1): 68-75 JAN 1 2007 Said, HM (Said, Harun M.); Staab, A (Staab, Adrian); Hagemann, C (Hagemann, Carsten); Vince, GH (Vince, Giles H.); Katzer, A (Katzer, Astrid); Flentje, M (Flentje, Michael); Vordermark, D (Vordermark, Dirk) Distinct patterns of hypoxic expression of carbonic anhydrase IX (CA IX) in human malignant glioma cell lines JOURNAL OF NEURO-ONCOLOGY, 81 (1): 27-38 JAN 2007 Manokaran S (Manokaran, Sumathra)1, Berg A (Berg, Alexander)1, Zhang X (Zhang, Xing)2, Chen W (Chen, Wei)2, Srivastava DK (Srivastava, D. K.)1 Modulation of Ligand Binding Affinity of Tumorigenic Carbonic Anhydrase XII Upon Interaction with Cationic CdTe Quantum Dots JOURNAL OF BIOMEDICAL NANOTECHNOLOGY Volume: 4 Issue: 4 Pages: 491-498 Published: DEC 2008 Zhang, M., Chen, Q., Li, X.-F., O'Donoghue, J., Ruan, S., Zanzonico, P., Ling, C.C., Humm, J.L. Image deconvolution in digital autoradiography: A preliminary study Medical Physics 35 (2), pp. 522-530 ,2008 Kirkpatrick, J.P.a , Rabbani, Z.N.a , Bentley, R.C.b , Hardee, M.E.b , Karol, S.a , Meyer, J.a , Oosterwijk, E.c , Havrilesky, L.d , Secord, A.A.d , Vujaskovic, Z.a , Dewhirst, M.W.a , Jones, E.L. Elevated CAIX expression is associated with an increased risk of distant failure in early-stage cervical cancer Biomarker Insights 2008 (3), pp. 45-55 Stec, R., Wcisło, G., Szczylik, C. Adjuvant treatment in renal cancer | [Rola leczenia uzupełniaja¸cego w przebiegu raka nerki Wspolczesna Onkologia 12 (7), pp. 301-307 , 2008 He, F.a , Deng, X.a , Wen, B.a , Liu, Y.a , Sun, X.b , Xing, L.a , Minami, A.a , Huang, Y.a , Chen, Q.b , Zanzonico, P.B.b , Ling, C.C.b , Li, G.C Noninvasive molecular imaging of hypoxia in human xenografts: Comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers Cancer Research 68 (20), pp. 8597-8606 , 2008 Russo P, O'Brien MF Surgical intervention in Patients with Metastatic Renal Cancer: Metastasectomy and Cytoreductive Nephrectomy UROLOGIC CLINICS OF NORTH AMERICA Volume: 35 Issue: 4 Pages: 679-686 Published: NOV 2008 Supuran CT Carbonic Anhydrase Inhibitors: Possible Anticancer Drugs With a Novel Mechanism of Action DRUG DEVELOPMENT RESEARCH Volume: 69 Issue: 6 Special Issue: Sp. Iss. SI Pages: 297-303 Published: SEP 2008 Sutton TA (Sutton, Timothy A.), Wilkinson J (Wilkinson, Jared), Mang HE (Mang, Henry E.), Knipe NL (Knipe, Nicole L.), Plotkin Z (Plotkin, Zoya), Hosein M (Hosein, Maya), Zak K (Zak, Katelyn), Wittenborn J (Wittenborn, Jeremy), Dagher PC (Dagher, Pierre C.)1 p53 regulates renal expression of HIF-1 alpha and pVHL under physiological conditions and after ischemia-reperfusion injury AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Volume: 295 Issue: 6 Pages: F1666-F1677 Published: DEC 2008 Snyder SA (Snyder, S. A.)1, Dewhirst MW (Dewhirst, M. W.)2, Hauck ML (Hauck, M. L.)1 The role of hypoxia in canine cancer VETERINARY AND COMPARATIVE ONCOLOGY Volume: 6 Issue: 4 Pages: 213-223 Published: DEC 2008 Semenza GL Tumor metabolism: cancer cells give and take lactate JOURNAL OF CLINICAL INVESTIGATION Volume: 118 Issue: 12 Pages: 3835-3837 Published: DEC 2008 He FQ (He, Fuqiu)1, Deng XL (Deng, Xuelong)1, Wen BX (Wen, Bixiu)1, Liu YP (Liu, Yueping)1, Sun XR (Sun, Xiaorong)2, Xing LG (Xing, Ligang)1, Minami A (Minami, Akiko)1, Huang YH (Huang, Yunhong)1, Chen Q (Chen, Qing)2, Zanzonico PB (Zanzonico, Pat B.)2, Ling CC (Ling, C. Clifton)2, Li GC (Li, Gloria C.)1,2 Noninvasive Molecular Imaging of Hypoxia in Human Xenografts: Comparing Hypoxia Induced Gene Expression with Endogenous and Exogenous Hypoxia Markers CANCER RESEARCH Volume: 68 Issue: 20 Pages: 8597-8606 Published: OCT 15 2008 Tanaka N (Tanaka, N.)1, Kato H (Kato, H.)1, Inose T (Inose, T.)1, Kimura H (Kimura, H.)1, Faried A (Faried, A.)1, Sohda M (Sohda, M.)1, Nakajima M (Nakajima, M.)1, Fukai Y (Fukai, Y.)1, Miyazaki T (Miyazaki, T.)1, Masuda N (Masuda, N.)1, Fukuchi M (Fukuchi, M.)1, Kuwano H (Kuwano, H.)1 Expression of carbonic anhydrase 9, a potential intrinsic marker of hypoxia, is associated with poor prognosis in oesophageal squamous cell carcinoma BRITISH JOURNAL OF CANCER Volume: 99 Issue: 9 Pages: 1468-1475 Published: OCT 28 2008 Xenaki G (Xenaki, G.)1, Ontikatze T (Ontikatze, T.)1, Rjaendran R (Rjaendran, R.)1, Startford IJ (Startford, I. J.)1, Drive C (Drive, C.)1,2, Krstic-Demonacos M (Krstic-Demonacos, M.)3, Demonacos C (Demonacos, C.)1 PCAF is an HIF-1 alpha cofactor that regulates p53 transcriptional activity in hypoxia ONCOGENE Volume: 27 Issue: 44 Pages: 5785-5796 Published: OCT 2 2008 Papaetis GS (Papaetis, George S.)1, Karapanagiotou LM (Karapanagiotou, Lena M.)1, Pandha H (Pandha, Hardev)2, Syrigos KN (Syrigos, Kostas N.)1 Targeted therapy for advanced renal cell cancer: Cytokines and beyond CURRENT PHARMACEUTICAL DESIGN Volume: 14 Issue: 22 Pages: 2229-2251 Published: AUG 2008 Lainakis G (Lainakis, Georgios)1, Bamias A (Bamias, Aristotle)1 Targeting angiogenesis in renal cell carcinoma CURRENT CANCER DRUG TARGETS Volume: 8 Issue: 5 Pages: 349-358 Published: AUG 2008 Hall RA, Vullo D, Innocenti A, External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans MOLECULAR AND BIOCHEMICAL PARASITOLOGY Volume: 161 Issue: 2 Pages: 140-149 Published: OCT 2008 Guler OO, Arslan O, Kockar F Differential in vitro inhibitory effects of anticancer drugs on tumor-associated carbonic anhydrase isozymes CA IX and CA XII METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY Volume: 30 Issue: 5 Pages: 335-340 Published: JUN 2008 Alexandru G (Alexandru, Gabriela)1, Graumann J (Graumann, Johannes)1, Smith GT (Smith, Geoffrey T.)1, Kolawa NJ (Kolawa, Natalie J.)1, Fang RH (Fang, Ruihua)1, Deshaies RJ (Deshaies, Raymond J.)1 UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1 alpha turnover CELL Volume: 134 Issue: 5 Pages: 804-816 Published: SEP 5 2008 Kaluz S, Kaluzova M, Stanbridge EJ Regulation of gene expression by hypoxia: Integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element CLINICA CHIMICA ACTA Volume: 395 Issue: 1-2 Pages: 6-13 Published: SEP 2008 Choi SW (Choi, Sung-Weon)2, Kim JY (Kim, Joo-Young)2, Park JY (Park, Joo-Yong)2, Cha IH (Cha, In-Ho)3, Kim J (Kim, Jin)4, Lee S (Lee, Sun)1 Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinomas HUMAN PATHOLOGY Volume: 39 Issue: 9 Pages: 1317-1322 Published: SEP 2008 Salnikow K (Salnikow, Konstantin)1, Aprelikova O (Aprelikova, Olga)2, Ivanov S (Ivanov, Sergey)4, Tackett S (Tackett, Sean)2, Kaczmarek M (Kaczmarek, Monika)1, Karaczyn A (Karaczyn, Aldona)1, Yee H (Yee, Herman)3, Kasprzak KS (Kasprzak, Kazimierz S.)1, Niederhuber J (Niederhuber, John)2 Regulation of hypoxia-inducible genes by ETS1 transcription factor CARCINOGENESIS Volume: 29 Issue: 8 Pages: 1493-1499 Published: AUG 2008 Seenath, M.M.a b , Roberts, D.a , Cawthorne, C.a , Saunders, M.P.c , Armstrong, G.R.d , O'Dwyer, S.T.b , Stratford, I.J.e , Dive, C.a e f , Renehan, A.G Reciprocal relationship between expression of hypoxia inducible factor 1? (HIF-1?) and the pro-apoptotic protein Bid in ex vivo colorectal cancer British Journal of Cancer 99 (3), pp. 459-463 , 2008 Moser C (Moser, Christian)1,2, Lang SA (Lang, Sven A.)1,2, Mori A (Mori, Akira)1,2, Hellerbrand C (Hellerbrand, Claus)3, Schlitt HJ (Schlitt, Hans J.)1,2, Geissler EK (Geissler, Edward K.)1,2, Fogler WE (Fogler, William E.)4, Stoeltzing O (Stoeltzing, Oliver)1,2 ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo BMC CANCER Volume: 8 Article Number: 206 Published: JUL 23 2008 Eardley KS (Eardley, Kevin S.)2,3, Kubal C (Kubal, Chandrashekhar)1,3, Zehnder D (Zehnder, Daniel)4, Quinkler M (Quinkler, Marcus)5, Lepenies J (Lepenies, Julia), Savage CO (Savage, Caroline O.)1,6, Howie AJ (Howie, Alec J.)7, Kaur K (Kaur, Kirrenjit), Cooper MS (Cooper, Mark S.)3, Adu D (Adu, Dwomoa)1,3, Cockwell P (Cockwell, Paul)1,3 The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease KIDNEY INTERNATIONAL Volume: 74 Issue: 4 Pages: 495-504 Published: AUG 2008 Ozensoy O, Arslan O, Kockar F Differential in vitro inhibition effects of some antibiotics on tumor associated carbonic anhydrase isozymes of hCA-IX and hCA-XII JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Volume: 23 Issue: 4 Pages: 579-585 Published: 2008 Brouwers AH, Mulders PFA, Oyen WJG Carbonic anhydrase IX expression in clear cell renal cell carcinoma and normal tissues: Experiences from (radio) immunotherapy JOURNAL OF CLINICAL ONCOLOGY Volume: 26 Issue: 22 Pages: 3808-3809 Published: AUG 1 2008 Seenath MM (Seenath, M. M.)2, Roberts D (Roberts, D.)2, Cawthorne C (Cawthorne, C.)2, Saunders MP (Saunders, M. P.)3, Armstrong GR (Armstrong, G. R.)4, O'Dwyer ST (O'Dwyer, S. T.), Stratford IJ (Stratford, I. J.)5, Dive C (Dive, C.)2,5,6, Renehan AG (Renehan, A. G.)1,2,6 Reciprocal relationship between expression of hypoxia inducible factor 1 alpha (HIF-1 alpha) and the pro-apoptotic protein Bid in ex vivo colorectal cancer BRITISH JOURNAL OF CANCER Volume: 99 Issue: 3 Pages: 459-463 Published: JUL 29 2008 Koritsiadis G (Koritsiadis, George)1, Stravodimos K (Stravodimos, Konstantinos)1, Koutalellis G (Koutalellis, George)1, Agrogiannis G (Agrogiannis, Georgios)2, Koritsiadis S (Koritsiadis, Sotirios)3, Lazaris A (Lazaris, Andreas)2, Constantinides C (Constantinides, Constantinos)1 Immunohistochemical estimation of hypoxia in human obstructed bladder and correlation with clinical variables BJU INTERNATIONAL Volume: 102 Issue: 3 Pages: 328-332 Published: AUG 2008 Boutrid H (Boutrid, Hinda)1, Jockovich ME (Jockovich, Maria-Elena)1, Murray TG (Murray, Timothy G.)1, Pina Y (Pina, Yolanda)1, Feuer WJ (Feuer, William J.)1, Lampidis TJ (Lampidis, Theodore J.)2,3, Cebulla CM (Cebulla, Colleen M.)1 Targeting hypoxia, a novel treatment for advanced retinoblastoma INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Volume: 49 Issue: 7 Pages: 2799-2805 Published: JUL 2008 Alchera E (Alchera, Elisa)1, Tacchini L (Tacchini, Lorenza)2, Imarisio C (Imarisio, Chiara)1, Dal Ponte C (Dal Ponte, Caterina)1, De Ponti C (De Ponti, Cristina)2, Gammella E (Gammella, Elena)2, Cairo G (Cairo, Gaetano)2, Albano E (Albano, Emanuele)1, Carini R (Carini, Rita)1 Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cells HEPATOLOGY Volume: 48 Issue: 1 Pages: 230-239 Published: JUL 2008 Cho H (Cho, Hyunju)1, Lee HY (Lee, Ho-Youl)2, Ahn DR (Ahn, Dae-Ro)1, Kim SY (Kim, Sang Yoon)1, Kim S (Kim, Sunyun)1, Lee KB (Lee, Keun Byeol)3, Lee YM (Lee, You Mie)3, Park H (Park, Hyunsung)2, Yang EG (Yang, Eun Gyeong)1 Baicalein induces functional hypoxia-inducible factor-1 alpha and angiogenesis MOLECULAR PHARMACOLOGY Volume: 74 Issue: 1 Pages: 70-81 Published: JUL 2008 Patard JJ (Patard, Jean-Jacques)2, Fergelot P (Fergelot, Patricia)2, Karakiewicz PI (Karakiewicz, Pierre I.)3, Klatte T (Klatte, Tobias)1, Trinh QD (Trinh, Quoc-Dien)3, Rioux-Leclercq N (Rioux-Leclercq, Nathalie)2, Said JW (Said, Jonathan W.)1,4, Belldegrun AS (Belldegrun, Arie S.)1, Pantuck AJ (Pantuck, Allan J.)1 Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma INTERNATIONAL JOURNAL OF CANCER Volume: 123 Issue: 2 Pages: 395-400 Published: JUL 15 2008 Chowdhury R, Hardy A, Schofield CJ The human oxygen sensing machinery and its manipulation CHEMICAL SOCIETY REVIEWS Volume: 37 Issue: 7 Pages: 1308-1319 Published: 2008 Adamski JK (Adamski, J. K.)1,2, Estlin EJ (Estlin, E. J.)2, Makin GWJ (Makin, G. W. J.)1,2 The cellular adaptations to hypoxia as novel therapeutic targets in childhood cancer CANCER TREATMENT REVIEWS Volume: 34 Issue: 3 Pages: 231-246 Published: MAY 2008 Kyndi M (Kyndi, Marianne)1,2, Sorensen FB (Sorensen, Flemming B.)2, Knudsen H (Knudsen, Helle)3, Alsner J (Alsner, Jan)1, Overgaard M (Overgaard, Marie)4, Nielsen HM (Nielsen, Hanne M.)1, Overgaard J (Overgaard, Jens)1 Carbonic anhydrase IX and response to postmastectomy radiotherapy in high-risk breast cancer: a subgroup analysis of the DBCG82 b and c trials BREAST CANCER RESEARCH Volume: 10 Issue: 2 Article Number: R24 Published: 2008 Barnett DH (Barnett, Daniel H.)2,4, Sheng S (Sheng, Shubin)1, Charn TH (Charn, Tze Howe)3, Waheed A (Waheed, Abdul)5, Sly WS (Sly, William S.)5, Lin CY (Lin, Chin-Yo)6,7, Liu ET (Liu, Edison T.)7, Katzenellenbogen BS (Katzenellenbogen, Benita S.)1,2,4 Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer CANCER RESEARCH Volume: 68 Issue: 9 Pages: 3505-3515 Published: MAY 1 2008 Wijffels KIEM (Wijffels, Karien I. E. M.)2, Marres HAM (Marres, Henri A. M.)2, Peters JPW (Peters, Johannes P. W.)1, Rijken PFJW (Rijken, Paulus F. J. W.)1, van der Kogel AJ (van der Kogel, Albert J.)1, Kaanders JHAM (Kaanders, Johannes H. A. M.)1 Tumour cell proliferation under hypoxic conditions in human head and neck squamous cell carcinomas ORAL ONCOLOGY Volume: 44 Issue: 4 Pages: 335-344 Published: APR 2008 Winum JY (Winum, Jean-Yves)2, Rami M (Rami, Marouan)2, Scozzafava A (Scozzafava, Andrea)1, Montero JL (Montero, Jean-Louis)2, Supuran C (Supuran, Claudiu Carbonic anhydrase IX: A new druggable target for the design of antitumor agents MEDICINAL RESEARCH REVIEWS Volume: 28 Issue: 3 Pages: 445-463 Published: MAY 2008 Saczewski F (Saczewski, Franciszek)1, Innocenti A (Innocenti, Alessio)2, Slawinski J (Slawinski, Jaroslaw)1, Kornicka A (Kornicka, Anita)1, Brzozowski Z (Brzozowski, Zdzislaw)1, Pomarnacka E (Pomarnacka, Elzbieta)1, Scozzafava A (Scozzafava, Andrea)2, Temperini C (Temperini, Claudia)2, Supuran CT (Supuran, Claudiu T.)2 Carbonic anhydrase inhibitors: Inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides BIOORGANIC & MEDICINAL CHEMISTRY Volume: 16 Issue: 7 Pages: 3933-3940 Published: APR 1 2008 Greijer AE (Greijer, Astrid E.)1,2, Diemen PMDV (Diemen, Pien M. Delis-van)1,2, Fijneman RJA (Fijneman, Remond J. A.)1,2, Giles RH (Giles, Rachel H.)4, Voest EE (Voest, Emile E.)4, van Hinsbergh VWM (van Hinsbergh, Victor W. M.)3, Meijer GA (Meijer, Gerrit A.)1 Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum VIRCHOWS ARCHIV Volume: 452 Issue: 5 Pages: 535-544 Published: MAY 2008 Benizri E, Ginouves A, Berra E The magic of the hypoxia-signaling cascade CELLULAR AND MOLECULAR LIFE SCIENCES Volume: 65 Issue: 7-8 Pages: 1133-1149 Published: APR 2008 Oosterwijk E Carbonic anhydrase IX: historical and future perspectives Conference Information: International Carbonic Anhydrase IX (CAIX) Symposium, NOV, 2007 Brussels, BELGIUM BJU INTERNATIONAL Volume: 101 Pages: 2-7 Supplement: Suppl. 4 Published: JUN 2008 Shuch B, Li ZH, Belldegrun AS Carbonic anhydrase IX and renal cell carcinoma: prognosis, response to systemic therapy, and future vaccine strategies Conference Information: International Carbonic Anhydrase IX (CAIX) Symposium, NOV, 2007 Brussels, BELGIUM BJU INTERNATIONAL Volume: 101 Pages: 25-30 Supplement: Suppl. 4 Published: JUN 2008 Jensen HK (Jensen, Hanne Krogh)1, Nordsmark M (Nordsmark, Marianne)1,2, Donskov F (Donskov, Frede)1, Marcussen N (Marcussen, Niels)3,4, von der Maase H (von der Maase, Hans) Immunohistochemical expression of carbonic anhydrase IX assessed over time and during treatment in renal cell carcinoma BJU INTERNATIONAL Volume: 101 Pages: 41-44 Supplement: Suppl. 4 Published: JUN 2008 Klatte T, Belldegrun AS, Pantuck AJ The role of carbonic anhydrase IX as a molecular marker for transitional cell carcinoma of the bladder Conference Information: International Carbonic Anhydrase IX (CAIX) Symposium, NOV, 2007 Brussels, BELGIUM BJU INTERNATIONAL Volume: 101 Pages: 45-48 Supplement: Suppl. 4 Published: JUN 2008 Oosterwijk E (Oosterwijk, Egbert)1, Boerman OC (Boerman, Otto C.)1, Oyen WJC (Oyen, Wim J. C.)1, Old LJ (Old, Lloyd J.)2, Mulders PFA (Mulders, Peter F. A.)1 Antibody therapy in renal cell carcinoma WORLD JOURNAL OF UROLOGY Volume: 26 Issue: 2 Pages: 141-146 Published: APR 2008 Bache M (Bache, M.)2, Kappler M (Kappler, M.)2, Said HM (Said, H. M.)1, Staab A (Staab, A.)1, Vordermark D (Vordermark, D.)1,2 Detection and specific targeting of hypoxic regions within solid tumors: Current preclinical and clinical strategies CURRENT MEDICINAL CHEMISTRY Volume: 15 Issue: 4 Pages: 322-338 Published: FEB 2008 Bussink J (Bussink, Johan)1, van der Kogel AJ (van der Kogel, Albert J.)1, Kaanders JHAM (Kaanders, Johannes H. A. M.)1 Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer LANCET ONCOLOGY Volume: 9 Issue: 3 Pages: 288-296 Published: MAR 2008 Al-Ahmadie HA (Al-Ahmadie, Hikmat A.)1, Alden D (Alden, Darym)1, Qin LX (Qin, Li-Xuan)2, Olgac S (Olgac, Semra)1, Fine SW (Fine, Samson W.)1, Gopalan A (Gopalan, Anuradha)1, Russo P (Russo, Paul)3, Motzer RJ (Motzer, Robert J.)4, Reuter VE (Reuter, Victor E.)1, Tickoo SK (Tickoo, Satish K.)1 Carbonic anhydrase IX expression in clear cell renal cell carcinoma - An immunohistochemical study comparing 2 antibodies AMERICAN JOURNAL OF SURGICAL PATHOLOGY Volume: 32 Issue: 3 Pages: 377-382 Published: MAR 2008 Elser M (Elser, Michael)1, Borsig L (Borsig, Lubor)2, Hassa PO (Hassa, Paul O.)4, Erener S (Erener, Suheda)1, Messner S (Messner, Simon)1, Valovka T (Valovka, Taras)1, Keller S (Keller, Stephan)3, Gassmann M (Gassmann, Max)3, Hottiger MO (Hottiger, Michael O.)1 Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression MOLECULAR CANCER RESEARCH Volume: 6 Issue: 2 Pages: 282-290 Published: FEB 2008 Zhang M (Zhang, Mutian)1,2, Chen Q (Chen, Qing)1, Li XF (Li, Xiao-Feng)1, O'Donoghue J (O'Donoghue, Joseph)1, Ruan S (Ruan, Shutian)3, Zanzonico P (Zanzonico, Pat)1, Ling CC (Ling, C. Clifton)1, Humm JL (Humm, John L.)1 Image deconvolution in digital autoradiography: A preliminary study MEDICAL PHYSICS Volume: 35 Issue: 2 Pages: 522-530 Published: FEB 2008 Lam JS (Lam, John S.)3, Klatte T (Klatte, Tobias)3, Kim HL (Kim, Hyung L.)4, Patard JJ (Patard, Jean-Jacques)5, Breda A (Breda, Alberto)3, Zisman A (Zisman, Amnon)6, Pantuck AJ (Pantuck, Allan J.)3, Figlin RA (Figlin, Robert A.)1,2 Prognostic factors and selection for clinical studies of patients with kidney cancer CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY Volume: 65 Issue: 3 Pages: 235-262 Published: MAR 2008 Lee WY (Lee, Wen-Ying)1,4,5, Huang SC (Huang, Soon-Cen)2,6, Hsu KF (Hsu, Keng-Fu)3, Tzeng CC (Tzeng, Ching-Cherng)1, Shen WL (Shen, Wan-Lin)1 Roles for hypoxia-regulated genes during cervical carcinogenesis: Somatic evolution during the hypoxia-glycolysis-acidosis sequence GYNECOLOGIC ONCOLOGY Volume: 108 Issue: 2 Pages: 377-384 Published: FEB 2008 Becker CM (Becker, Christian M.)1,2,3, Rohwer N (Rohwer, Nadine)4, Funakoshi T (Funakoshi, Tae)2, Cramer T (Cramer, Thorsten)4, Bernhardt W (Bernhardt, Wanja)5, Birsner A (Birsner, Amy)2, Folkman J (Folkman, Judah)2, D'Amato RJ (D'Amato, Robert J.)2 2-methoxyestradiol inhibits hypoxia-inducible factor-1 alpha and suppresses growth of lesions in a mouse model of endometriosis AMERICAN JOURNAL OF PATHOLOGY Volume: 172 Issue: 2 Pages: 534-544 Published: FEB 2008 Rathmell WK, Chen S VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment EXPERT REVIEW OF ANTICANCER THERAPY Volume: 8 Issue: 1 Pages: 63-73 Published: JAN 2008 Mi J (Mi, Jing)1, Zhang XW (Zhang, Xiuwu)2, Rabbani ZN (Rabbani, Zahid N.)3, Liu YM (Liu, Yingmiao)1, Reddy SK (Reddy, Srinevas K.)1, Su Z (Su, Zhen)4, Salahuddin FK (Salahuddin, Fawzia K.)5, Viles K (Viles, Kristi)1, Giangrande PH (Giangrande, Paloma H.)1, Dewhirst MW (Dewhirst, Mark W.)3, Sullenger BA (Sullenger, Bruce A.)1, Kontos CD (Kontos, Christopher D.)5, Clary BM (Clary, Bryan M.)1 RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin MOLECULAR THERAPY Volume: 16 Issue: 1 Pages: 66-73 Published: JAN 2008 Kallio, H., Martinez, A.R., Hilvo, M., Hyrskyluoto, A., Parkkila, S. Cancer-associated carbonic anhydrases IX and XII: Effect of growth factors on gene expression in human cancer cell lines Journal of Cancer Molecules 5 (3), pp. 73-78 , 2009 Hulick, P.a , Zimmer, M.a , Margulis, V.g , Skates, S.b , Hamel, M.a , Dahl, D.M.c , Michaelson, D.M.a , Liebermann, T.d , Signoretti, S.e , Carney, W.f , Wood, C.g , Iliopoulos, O. Blood levels of carbonic anhydrase 9 correlate with clear cell renal cell carcinoma activity Clinical Proteomics 5 (1), pp. 37-45 , 2009 Sansone P (Sansone, Pasquale)1,2, Piazzi G (Piazzi, Giulia)1,5, Paterini P (Paterini, Paola)1,4,5, Strillacci A (Strillacci, Antonio)4, Ceccarelli C (Ceccarelli, Claudio)5, Minni F (Minni, Francesco)6, Biasco G (Biasco, Guido)7, Chieco P (Chieco, Pasquale)1, Bonafe M (Bonafe, Massimiliano)1,3 Cyclooxygenase-2/carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Volume: 13 Issue: 9B Pages: 3876-3887 Published: SEP 2009 Hoogsteen IJ (Hoogsteen, Ilse J.)1, Lok J (Lok, Jasper)1, Marres HAM (Marres, Henri A. M.)2, Takes RP (Takes, Robert P.)2, Rijken PFJW (Rijken, Paul F. J. W.)2, van der Kogel AJ (van der Kogel, Albert J.)1, Kaanders JHAM (Kaanders, Johannes H. A. M.)1 Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia EUROPEAN JOURNAL OF CANCER Volume: 45 Issue: 16 Pages: 2906-2914 Published: NOV 2009 Gallagher FA, Kettunen MI, Brindle KM Biomedical applications of hyperpolarized C-13 magnetic resonance imaging PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Volume: 55 Issue: 4 Pages: 285-295 Published: NOV 2009 Nualart F (Nualart, Francisco)2, Garcia MDLA (Garcia, Maria de los Angeles)2, Medina RA (Medina, Rodolfo A.)3, Owen GI (Owen, Gareth I.)1 Glucose Transporters in Sex Steroid Hormone Related Cancer CURRENT VASCULAR PHARMACOLOGY Volume: 7 Issue: 4 Pages: 534-548 Published: OCT 2009 Lopez M (Lopez, Marie)1, Paul B (Paul, Blessy)1, Hofmann A (Hofmann, Andreas)1, Morizzi J (Morizzi, Julia)2, Wu QK (Wu, Quoc K.)2, Charman SA (Charman, Susan A.)2, Innocenti A (Innocenti, Alessio)3, Vullo D (Vullo, Daniela)3, Supuran CT (Supuran, Claudiu T.)3, Poulsen SA (Poulsen, Sally-Ann)1 S-Glycosyl Primary Sulfonamides-A New Structural Class for Selective Inhibition of Cancer-Associated Carbonic Anhydrases JOURNAL OF MEDICINAL CHEMISTRY Volume: 52 Issue: 20 Pages: 6421-6432 Published: OCT 22 2009 Dubois L (Dubois, Ludwig)1, Lieuwes NG (Lieuwes, Natasja G.)1, Maresca A (Maresca, Alfonso)2, Thiry A (Thiry, Anne)1,3, Supuran CT (Supuran, Claudiu T.)2, Scozzafava A (Scozzafava, Andrea)2, Wouters BG (Wouters, Bradly G.)1,4,5,6, Lambin P (Lambin, Philippe)1 Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model RADIOTHERAPY AND ONCOLOGY Volume: 92 Issue: 3 Special Issue: Sp. Iss. SI Pages: 423-428 Published: SEP 2009 Kern J (Kern, Johann)1, Steurer M (Steurer, Michael)2, Gastl G (Gastl, Guenther)1, Gunsilius E (Gunsilius, Eberhard)1, Untergasser G (Untergasser, Gerold)1 Vasohibin inhibits angiogenic sprouting in vitro and supports vascular maturation processes in vivo BMC CANCER Volume: 9 Article Number: 284 Published: AUG 17 2009 van den Beucken T (van den Beucken, Twan)1,2, Ramaekers CHMA (Ramaekers, Chantal H. M. A.)2, Rouschop K (Rouschop, Kasper)1, Koritzinsky M (Koritzinsky, Marianne)1,2,3,4,5, Wouters BG (Wouters, Bradly G.)1,2,3,4,5 Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment RADIOTHERAPY AND ONCOLOGY Volume: 92 Issue: 3 Special Issue: Sp. Iss. SI Pages: 437-442 Published: SEP 2009 Yildirim H, Kockar F TGF-beta upregulates tumor-associated carbonic anhydrase IX gene expression in Hep3B cells CELL BIOLOGY INTERNATIONAL Volume: 33 Issue: 9 Pages: 1002-1007 Published: SEP 2009 Ahlskog JKJ (Ahlskog, J. K. J.)1, Schliemann C (Schliemann, C.)1, Marlind J (Marlind, J.)1, Qureshi U (Qureshi, U.)2, Ammar A (Ammar, A.)2, Pedley RB (Pedley, R. B.)2, Neri D (Neri, D.)1 Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours BRITISH JOURNAL OF CANCER Volume: 101 Issue: 4 Pages: 645-657 Published: AUG 11 2009 Stock C, Schwab A Protons make tumor cells move like clockwork PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY Volume: 458 Issue: 5 Pages: 981-992 Published: SEP 2009 Tennant DA (Tennant, Daniel A.)1, Duran RV (Duran, Raul V.)1, Boulahbel H (Boulahbel, Houda)1, Gottlieb E (Gottlieb, Eyal)1 Metabolic transformation in cancer CARCINOGENESIS Volume: 30 Issue: 8 Pages: 1269-1280 Published: AUG 2009 Koop EA (Koop, Esther A.)1, van Laar T (van Laar, Theo)1, van Wichen DF (van Wichen, Dick F.)1, de Weger RA (de Weger, Roel A.)1, van der Wall E (van der Wall, Elsken)2, van Diest PJ (van Diest, Paul J.)1 Expression of BNIP3 in invasive breast cancer: correlations with the hypoxic response and clinicopathological features BMC CANCER Volume: 9 Article Number: 175 Published: JUN 9 2009 Harten SK (Harten, Sarah K.)1, Esteban MA (Esteban, Miguel A.)2, Maxwell PH (Maxwell, Patrick H.)1 Identification of novel VHL regulated genes by transcriptomic analysis of RCC10 renal carcinoma cells ADVANCES IN ENZYME REGULATION, VOL 49 Book Series: ADVANCES IN ENZYME REGULATION Volume: 49 Pages: 43-52 Published: 2009 Sar A (Sar, Aylin)1,2,3,4, Ponjevic D (Ponjevic, Dragana)1,2,3,4, Nguyen M (Nguyen, Monica)1,2,3,4, Box AH (Box, Adrian Harold)1,2,3,4, Demetrick DJ (Demetrick, Douglas James)1,2,3,4,5 Identification and characterization of demethylase JMJD1A as a gene upregulated in the human cellular response to hypoxia CELL AND TISSUE RESEARCH Volume: 337 Issue: 2 Pages: 223-234 Published: AUG 2009 Aubert S (Aubert, Sebastien)1,3, Fauquette V (Fauquette, Valerie)1, Hemon B (Hemon, Brigitte)1, Lepoivre R (Lepoivre, Rejane)1, Briez N (Briez, Nicolas)1,2, Bernard D (Bernard, David)4,5, Van Seuningen I (Van Seuningen, Isabelle)1, Leroy X (Leroy, Xavier)1,3, Perrais M (Perrais, Michael)1 MUC1, a New Hypoxia Inducible Factor Target Gene, Is an Actor in Clear Renal Cell Carcinoma Tumor Progression CANCER RESEARCH Volume: 69 Issue: 14 Pages: 5707-5715 Published: JUL 15 2009 Ahlskog JKJ (Ahlskog, Julia K. J.)1, Dumelin CE (Dumelin, Christoph E.)2, Trussel S (Truessel, Sabrina)1, Marlind J (Marlind, Jessica)1, Neri D (Neri, Dario)1 In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 19 Issue: 16 Pages: 4851-4856 Published: AUG 15 2009 Li Y (Li, Ying)1, Wang H (Wang, Hai)1, Oosterwijk E (Oosterwijk, Egbert)3, Selman Y (Selman, Yamil)2, Mira JC (Mira, Juan C.)2, Medrano T (Medrano, Theresa)2, Shiverick KT (Shiverick, Kathleen T.)2, Frost SC (Frost, Susan C.)1 Antibody-specific detection of CAIX in breast and prostate cancers BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Volume: 386 Issue: 3 Pages: 488-492 Published: AUG 28 2009 Winum JY (Winum, Jean-Yves)1, Scozzafava A (Scozzafava, Andrea)2, Montero JL (Montero, Jean-Louis)1, Supuran CT (Supuran, Claudiu T.)2 Inhibition of Carbonic Anhydrase IX: A New Strategy Against Cancer ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY Volume: 9 Issue: 6 Pages: 693-702 Published: JUL 2009 Cheong SC (Cheong, S. C.)1, Chandramouli GVR (Chandramouli, G. V. R.)2, Saleh A (Saleh, A.)1, Zain RB (Zain, R. B.)3, Lau SH (Lau, S. H.)4, Sivakumaren S (Sivakumaren, S.)5, Pathmanathan R (Pathmanathan, R.)5, Prime SS (Prime, S. S.)6, Teo SH (Teo, S. H.)1, Patel V (Patel, V.)7, Gutkind JS (Gutkind, J. S.) Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure ORAL ONCOLOGY Volume: 45 Issue: 8 Pages: 712-719 Published: AUG 2009 Gardner TA, Logan T Prognostic Implications of Polymorphisms and Interleukin-2 Therapy for Renal Cell Carcinoma JOURNAL OF UROLOGY Volume: 182 Issue: 2 Pages: 425-426 Published: AUG 2009 Dooms C (Dooms, Christophe)1,2, van Baardwijk A (van Baardwijk, Angela)3, Verbeken E (Verbeken, Eric)4, van Suylen RJ (van Suylen, Robert Jan)5, Stroobants S (Stroobants, Sigrid)6, De Ruysscher D (De Ruysscher, Dirk)3, Vansteenkiste J (Vansteenkiste, Johan)2 Association Between 18F-Fluoro-2-Deoxy-D-Glucose Uptake Values and Tumor Vitality: Prognostic Value of Positron Emission Tomography in Early-Stage Non-small Cell Lung Cancer JOURNAL OF THORACIC ONCOLOGY Volume: 4 Issue: 7 Pages: 822-828 Published: JUL 2009 Li Y (Li, Ying)1, Wang H (Wang, Hai)1, Oosterwijk E (Oosterwijk, Egbert)3, Tu CK (Tu, Chingkuang)2, Shiverick KT (Shiverick, Kathleen T.)2, Silverman DN (Silverman, David N.)2, Frost SC (Frost, Susan C.)1 Expression and Activity of Carbonic Anhydrase IX Is Associated With Metabolic Dysfunction in MDA-MB-231 Breast Cancer Cells CANCER INVESTIGATION Volume: 27 Issue: 6 Pages: 613-623 Published: 2009 Chaudary N, Hill RP Increased expression of metastasis-related genes in hypoxic cells sorted from cervical and lymph nodal xenograft tumors LABORATORY INVESTIGATION Volume: 89 Issue: 5 Pages: 587-596 Published: MAY 2009 Liao SY, Lerman MI, Stanbridge EJ Expression of transmembrane carbonic anhydrases, CAIX and CAXII, in human development BMC DEVELOPMENTAL BIOLOGY Volume: 9 Article Number: 22 Published: MAR 16 2009 Kaluz S (Kaluz, Stefan)1, Kaluzova M (Kaluzova, Milota)1, Liao SY (Liao, Shu-Yuan)2, Lerman M (Lerman, Michael)3, Stanbridge EJ (Stanbridge, Eric J.)1 Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show? BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER Volume: 1795 Issue: 2 Pages: 162-172 Published: APR 2009 Jensen RL Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target JOURNAL OF NEURO-ONCOLOGY Volume: 92 Issue: 3 Pages: 317-335 Published: MAY 2009 Thirabanjasak D (Thirabanjasak, Duangpen)1,2, Basturk O (Basturk, Olca)3, Altinel D (Altinel, Deniz)4, Cheng JD (Cheng, Jeanette D.)6, Adsay NV (Adsay, N. Volkan)5 Is Serous Cystadenoma of the Pancreas a Model of Clear-Cell-Associated Angiogenesis and Tumorigenesis PANCREATOLOGY Volume: 9 Issue: 1-2 Pages: 182-188 Published: 2009 Wijffels KIEM (Wijffels, Karien I. E. M.)4, Hoogsteen IJ (Hoogsteen, Ilse J.)3, Lok J (Lok, Jasper)1, Rijken PFJW (Rijken, Paulus F. J. W.)1, Marres HAM (Marres, Henri A. M.)3, de Wilde PCM (de Wilde, Peter C. M.)2, van der Kogel AJ (van der Kogel, Albert J.)1, Kaanders JHAM (Kaanders, Johannes H. A. M.)1 NO DETECTABLE HYPOXIA IN MALIGNANT SALIVARY GLAND TUMORS: PRELIMINARY RESULTS INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS Volume: 73 Issue: 5 Pages: 1319-1325 Published: APR 1 2009 Singer M (Singer, Mathilde)1, Lopez M (Lopez, Marie)1, Bornaghi LF (Bornaghi, Laurent F.)1, Innocenti A (Innocenti, Alessio)2, Vullo D (Vullo, Daniela)2, Supuran CT (Supuran, Claudiu T.)2, Poulsen SA (Poulsen, Sally-Ann)1 Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 19 Issue: 8 Pages: 2273-2276 Published: APR 15 2009 Ranalli NJ (Ranalli, Nathan J.)1, Evans SM (Evans, Sydney M.)2, Ju KD (Ju, Kevin D.)1 Hypoxia in Brain Tumors A Review of the Literature NEUROSURGERY QUARTERLY Volume: 19 Issue: 1 Pages: 1-12 Published: MAR 2009 Klatte T (Klatte, Tobias)1, Seligson DB (Seligson, David B.)2, Rao JY (Rao, Jian Yu)2, Yu H (Yu, Hong)2, de Martino M (de Martino, Michela)1, Kawaoka K (Kawaoka, Kelly)1, Wong SG (Wong, Steven G.)3, Belldegrun AS (Belldegrun, Arie S.)1, Pantuck AJ (Pantuck, Allan J.)1 Carbonic Anhydrase IX in Bladder Cancer A Diagnostic, Prognostic, and Therapeutic Molecular Marker CANCER Volume: 115 Issue: 7 Pages: 1448-1458 Published: APR 1 2009 Korkeila E (Korkeila, E.)1, Talvinen K (Talvinen, K.)2, Jaakkola PM (Jaakkola, P. M.)1,3,4, Minn H (Minn, H.)1,5, Syrjanen K (Syrjanen, K.)1, Sundstrom J (Sundstrom, J.)2,6, Pyrhonen S (Pyrhonen, S.) Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer BRITISH JOURNAL OF CANCER Volume: 100 Issue: 6 Pages: 874-880 Published: MAR 17 2009 Hong SW (Hong, Sun Woo)2,3, Yoo JW (Yoo, Jae Wook)2,3, Kang HS (Kang, Hye Suk)2,3, Kim S (Kim, Soyoun)1, Lee DK (Lee, Dong-ki)2,3 HIF-1 alpha-dependent gene expression program during the nucleic acid-triggered antiviral innate immune responses MOLECULES AND CELLS Volume: 27 Issue: 2 Pages: 243-250 Published: FEB 2009 Debucquoy A (Debucquoy, Annelies)1, Goethals L (Goethals, Laurence)2,4, Libbrecht L (Libbrecht, Louis), Perneel C (Perneel, Christiaan)3, Geboes K (Geboes, Karel)4, Ectors N (Ectors, Nadine)4, McBride W (McBride, William H.)5, Haustermans K (Haustermans, Karin) Molecular and clinico-pathological markers in rectal cancer: a tissue micro-array study INTERNATIONAL JOURNAL OF COLORECTAL DISEASE Volume: 24 Issue: 2 Pages: 129-138 Published: FEB 2009 Aragones J (Aragones, Julian)1,2, Fraisl P (Fraisl, Peter)1,2, Baes M (Baes, Myriam)3, Carmeliet P (Carmeliet, Peter)1,2 Oxygen Sensors at the Crossroad of Metabolism CELL METABOLISM Volume: 9 Issue: 1 Pages: 11-22 Published: JAN 7 2009 Chiche J (Chiche, Johanna)1, Ilc K (Ilc, Karine)1, Laferriere J (Laferriere, Julie)1, Trottier E (Trottier, Eric)1, Dayan F (Dayan, Frederic)1, Mazure NM (Mazure, Nathalie M.)1, Brahimi-Horn MC (Brahimi-Horn, M. Christiane)1, Pouyssegur J (Pouyssegur, Jacques)1 Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH CANCER RESEARCH Volume: 69 Issue: 1 Pages: 358-368 Published: JAN 1 2009 Esbaugh AJ (Esbaugh, Andrew J.)1, Perry SF (Perry, S. F.), Gilmour KM (Gilmour, K. M Hypoxia-inducible carbonic anhydrase IX expression is insufficient to alleviate intracellular metabolic acidosis in the muscle of zebrafish, Danio rerio AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY Volume: 296 Issue: 1 Pages: R150-R160 Published: JAN 2009 Phoenix KN (Phoenix, Kathryn N.)1, Vumbaca F (Vumbaca, Frank)1, Claffey KP (Claffey, Kevin P.)1 Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ER alpha negative MDA-MB-435 breast cancer model BREAST CANCER RESEARCH AND TREATMENT Volume: 113 Issue: 1 Pages: 101-111 Published: JAN 2009 Cheng L (Cheng, Liang)1,2, Zhang SB (Zhang, Shaobo)1, MacLennan GT (MacLennan, Gregory T.)3, Lopez-Beltran A (Lopez-Beltran, Antonio)4, Montironi R (Montironi, Rodolfo)5 Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms HUMAN PATHOLOGY Volume: 40 Issue: 1 Pages: 10-29 Published: JAN 2009 Chi, N., Maranchie, J.K., Appleman, L.J., Storkus, W.J. Update on vaccine development for renal cell cancer Open Access Journal of Urology 2 (1), pp. 125-141 , 2010 Barcelona, P.F.a , Luna, J.D.b , Chiabrando, G.A.a , Juarez, C.P.b , Bhutto, I.A.c , Baba, T.c , McLeod, D.S.c , Sánchez, M.C.a , Lutty, G.A.Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and ?2-Macroglobulin in retinal and choroidal tissue of proliferative retinopathies Experimental Eye Research 91 (2), pp. 264-272 , 2010 Seo, T., Konda, R., Sugimura, J., Iwasaki, K., Nakamura, Y., Fujioka, T. Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy Oncology Letters 1 (4), pp. 697-701 , 2010 Boticario CB, Angosto MC Hypoxia and cancer ANALES DE LA REAL ACADEMIA NACIONAL DE FARMACIA Volume: 76 Issue: 3 Pages: 379-408 Published: 2010 Askoxylakis V (Askoxylakis, Vasileios)1, Garcia-Boy R (Garcia-Boy, Regine)2, Rana S (Rana, Shoaib)2, Kramer S (Kraemer, Susanne)2, Hebling U (Hebling, Ulrike)2, Mier W (Mier, Walter)2, Altmann A (Altmann, Annette)3, Markert A (Markert, Annette)3, Debus J (Debus, Juergen)1, Haberkorn U (Haberkorn, Uwe A New Peptide Ligand for Targeting Human Carbonic Anhydrase IX, Identified through the Phage Display Technology PLOS ONE Volume: 5 Issue: 12 Article Number: e15962 Published: DEC 31 2010 Tostain J (Tostain, Jacques)1, Li GR (Li, Guorong)1, Gentil-Perret A (Gentil-Perret, Anne)2, Gigante M (Gigante, Marc) Carbonic anhydrase 9 in clear cell renal cell carcinoma: A marker for diagnosis, prognosis and treatment EUROPEAN JOURNAL OF CANCER Volume: 46 Issue: 18 Pages: 3141-3148 Published: DEC 2010 Minogue BM (Minogue, Ben M.), Richardson SM (Richardson, Stephen M.), Zeef LAH (Zeef, Leo A. H.), Freemont AJ (Freemont, Anthony J.), Hoyland JA (Hoyland, Judith A Characterization of the Human Nucleus Pulposus Cell Phenotype and Evaluation of Novel Marker Gene Expression to Define Adult Stem Cell Differentiation ARTHRITIS AND RHEUMATISM Volume: 62 Issue: 12 Pages: 3695-3705 Published: DEC 2010 Yoo CW (Yoo, Chong Woo)1, Nam BH (Nam, Byung-Ho)1, Kim JY (Kim, Joo-Young)1, Shin HJ (Shin, Hye-Jin)1, Lim H (Lim, Hyunsun)2, Lee S (Lee, Sun)3, Lee SK (Lee, Su-Kyoung)1, Lim MC (Lim, Myong-Cheol)1, Song YJ (Song, Yong-Jung) Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome RADIATION ONCOLOGY Volume: 5 Article Number: 101 Published: NOV 1 2010 Bramfeldt H (Bramfeldt, H.)1,2, Sabra G (Sabra, G.)1,2, Centis V (Centis, V.)1,2, Vermette P (Vermette, P Scaffold Vascularization: A Challenge for Three-Dimensional Tissue Engineering CURRENT MEDICINAL CHEMISTRY Volume: 17 Issue: 33 Pages: 3944-3967 Published: NOV 2010 van de Nieuwenhof HP (van de Nieuwenhof, Hedwig P.)1,2, de Hullu JA (de Hullu, Joanne A.)1,2, Kaanders JHAM (Kaanders, Johannes H. A. M.)3, Bulten J (Bulten, Johan)4, Massuger LFAG (Massuger, Leon F. A. G.)1,2, van Kempen LCLT (van Kempen, Leon C. L. T Hemoglobin level predicts outcome for vulvar cancer patients independent of GLUT-1 and CA-IX expression in tumor tissue VIRCHOWS ARCHIV Volume: 457 Issue: 6 Pages: 693-703 Published: DEC 2010 Supuran CT (Supuran, Claudiu T.)2, Di Fiore A (Di Fiore, Anna)1, Alterio V (Alterio, Vincenzo)1, Monti SM (Monti, Simona Maria)1, De Simone G (De Simone, Giuseppina)1 Recent Advances in Structural Studies of the Carbonic Anhydrase Family: The Crystal Structure of Human CA IX and CA XIII CURRENT PHARMACEUTICAL DESIGN Volume: 16 Issue: 29 Pages: 3246-3254 Published: 2010 Lopez M (Lopez, Marie)1, Salmon AJ (Salmon, Adam J.)1, Supuran CT (Supuran, Claudiu T.)2, Poulsen SA (Poulsen, Sally-Ann) Carbonic Anhydrase Inhibitors Developed Through 'Click Tailing' CURRENT PHARMACEUTICAL DESIGN Volume: 16 Issue: 29 Pages: 3277-3287 Published: 2010 Said HM (Said, Harun M.)1, Supuran CT (Supuran, Claudiu T.)2, Hageman C (Hageman, Carsten)3, Staab A (Staab, Adrian)1,4, Polat B (Polat, Buelent)1, Katzer A (Katzer, Astrid)1, Scozzafava A (Scozzafava, Andrea)2, Anacker J (Anacker, Jelena), Flentje M (Flentje, Michael)1, Vordermark D (Vordermark, Dirk Modulation of Carbonic Anhydrase 9 (CA9) in Human Brain Cancer CURRENT PHARMACEUTICAL DESIGN Volume: 16 Issue: 29 Pages: 3288-3299 Published: 2010 Nyhan MJ (Nyhan, Michelle J.)1, El Mashad SM (El Mashad, Shereen M.)1, O'Donovana TR (O'Donovana, Tracey R.)1, Ahmad S (Ahmad, Sarfraz)1,2, Collins C (Collins, Chris)1, Sweeney P (Sweeney, Paul)2, Rogers E (Rogers, Eamonn)2, O'Sullivan GC (O'Sullivan, Gerald C.)1,2, McKenna SL (McKenna, Sharon L VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin ANALYTICAL CELLULAR PATHOLOGY-CELLULAR ONCOLOGY Volume: 33 Issue: 3-4 Pages: 121-132 Published: 2010 Zheng GP (Zheng, Guopei)1, Zhou M (Zhou, Min)1, Ou XR (Ou, Xinrong)2, Peng B (Peng, Bo)1, Yu YH (Yu, Yanhui)1, Kong FR (Kong, Fangren)1, Ouyang YM (Ouyang, Yongmei)1, He ZM (He, Zhimin Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells FEBS JOURNAL Volume: 277 Issue: 21 Pages: 4506-4518 Published: NOV 2010 Park HR (Park, Hye-Rim)1, Seo J (Seo, Jinwon)1, Bacchini P (Bacchini, Patrizia)2, Bertoni F (Bertoni, Franco)3, Park YK (Park, Yong-Koo Expression of Carbonic Anhydrase IX Correlates with Histologic Grade and Metastasis in Osteosarcoma KOREAN JOURNAL OF PATHOLOGY Volume: 44 Issue: 4 Pages: 384-389 Published: AUG 2010 Pinto A (Pinto, Alvaro)1, Redondo A (Redondo, Andres)1, Zamora P (Zamora, Pilar)1, Castelo B (Castelo, Beatriz)1, Espinosa E (Espinosa, Enrique Angiogenesis as a therapeutic target in urothelial carcinoma ANTI-CANCER DRUGS Volume: 21 Issue: 10 Pages: 890-896 Published: NOV 2010 Rami M (Rami, Marouan)1, Montero JL (Montero, Jean-Louis)1, Dubois L (Dubois, Ludwig)2, Lambin P (Lambin, Philippe)2, Scozzafava A (Scozzafava, Andrea)3, Winum JY (Winum, Jean-Yves)1, Supuran CT (Supuran Carbonic anhydrase inhibitors: Gd(III) complexes of DOTA- and TETA-sulfonamide conjugates targeting the tumor associated carbonic anhydrase isozymes IX and XII NEW JOURNAL OF CHEMISTRY Volume: 34 Issue: 10 Pages: 2139-2144 Published: 2010 Keranen MAI (Keranen, Mikko A. I.)1, Nykanen AI (Nykanen, Antti I.)1, Krebs R (Krebs, Rainer)1, Pajusola K (Pajusola, Katri)3, Tuuminen R (Tuuminen, Raimo)1, Alitalo K (Alitalo, Kari)3, Lemstrom KB (Lemstrom, Karl B.) Cardiomyocyte-targeted HIF-1 alpha gene therapy inhibits cardiomyocyte apoptosis and cardiac alllograft vasculopathy in the rat JOURNAL OF HEART AND LUNG TRANSPLANTATION Volume: 29 Issue: 9 Pages: 1058-1066 Published: SEP 2010 Prencipe M (Prencipe, Maria)1, McGoldrick A (McGoldrick, Aloysius)1, Perry AS (Perry, Antoinette S.)2, O'Grady A (O'Grady, Anthony)3, Phelan S (Phelan, Sine)1, McGrogan B (McGrogan, Barbara)1, Fitzpatrick P (Fitzpatrick, Patricia)4, Watson JA (Watson, Jenny A.)1, Furlong F (Furlong, Fiona)1, Brennan DJ (Brennan, Donal J.)5, Lawler M (Lawler, Mark)2, Kay E (Kay, Elaine)3, McCann A (McCann, Amanda MAD2 downregulation in hypoxia is independent of promoter hypermethylation CELL CYCLE Volume: 9 Issue: 14 Pages: 2856-2865 Published: JUL 15 2010 Schelter F (Schelter, Florian)1, Gerg M (Gerg, Michael)1, Halbgewachs B (Halbgewachs, Birgit)1, Schaten S (Schaten, Susanne)1, Gorlach A (Goerlach, Agnes)2, Schrotzlmair F (Schroetzlmair, Florian)1, Kruger A (Krueger, Achim Identification of a Survival-independent Metastasis-enhancing Role of Hypoxia-inducible Factor-1 alpha with a Hypoxia-tolerant Tumor Cell Line JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 285 Issue: 34 Pages: 26182-26189 Published: AUG 20 2010 Zumsteg A (Zumsteg, Adrian), Strittmatter K (Strittmatter, Karin), Klewe-Nebenius D (Klewe-Nebenius, Daniela)2, Antoniadis H (Antoniadis, Helena), Christofori G (Christofori, Gerhard) A bioluminescent mouse model of pancreatic beta-cell carcinogenesis CARCINOGENESIS Volume: 31 Issue: 8 Pages: 1465-1474 Published: AUG 2010 Kallio H (Kallio, Heini)1,2,3, Hilvo M (Hilvo, Mika)4, Rodriguez A (Rodriguez, Alejandra)1,2,3, Lappalainen EH (Lappalainen, Eeva-Helena)1,2,3, Lappalainen AM (Lappalainen, Anna-Maria)1,2,3, Parkkila S (Parkkila, Seppo Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach BMC GENOMICS Volume: 11 Article Number: 397 Published: JUN 23 2010 Chiche J (Chiche, Johanna)1, Ilc K (Ilc, Karine)1, Brahimi-Horn MC (Brahimi-Horn, M. Christiane)1, Pouyssegur J (Pouyssegur, Jacques Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration 50th International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues Univ Bologna, Bologna, ITALY, SEP 27-29, 2009 ADVANCES IN ENZYME REGULATION, VOL 50 Book Series: Advances in Enzyme Regulation Volume: 50 Pages: 20-33 Published: 2010 Stubbs M, Griffiths JR The altered metabolism of tumors: HIF-1 and its role in the Warburg effect Conference Information: 50th International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues, SEP 27-29, 2009 Univ Bologna, Bologna, ITALY, ADVANCES IN ENZYME REGULATION, VOL 50 Book Series: Advances in Enzyme Regulation Volume: 50 Pages: 44-55 Published: 2010 Hoeben BAW (Hoeben, Bianca A. W.)1, Kaanders JHAM (Kaanders, Johannes H. A. M.)1, Franssen GM (Franssen, Gerben M.)2, Troost EGC (Troost, Esther G. C.)1, Rijken PFJW (Rijken, Paul F. J. W.)1, Oosterwijk E (Oosterwijk, Egbert)3, van Dongen GAMS (van Dongen, Guus A. M. S.)4, Oyen WJG (Oyen, Wim J. G.)2, Boerman OC (Boerman, Otto C.)2, Bussink J (Bussink, Johan PET of Hypoxia with Zr-89-Labeled cG250-F(ab ')(2) in Head and Neck Tumors JOURNAL OF NUCLEAR MEDICINE Volume: 51 Issue: 7 Pages: 1076-1083 Published: JUL 1 2010 Kim HS (Kim, Hyo Song)1, Kim WS (Kim, Won Seog)1, Park SH (Park, Se Hoon)1, Jung CW (Jung, Chul Won)1, Choi HY (Choi, Han Yong)2, Lee HM (Lee, Hyun Moo)2, Jeon SS (Jeon, Seong Soo)2, Ha H (Ha, Hongil)3, Hwang IG (Hwang, In Gyu)4, Lee S (Lee, Seungkoo)5, Lim HY (Lim, Ho Yeong Molecular biomarkers for advanced renal cell carcinoma: Implications for prognosis and therapy UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS Volume: 28 Issue: 2 Pages: 157-163 Published: MAR-APR 2010 Gramley F (Gramley, Felix)1, Lorenzen J (Lorenzen, Johann)2, Jedamzik B (Jedamzik, Britta)2, Gatter K (Gatter, Kevin)3, Koellensperger E (Koellensperger, Eva)4, Munzel T (Munzel, Thomas), Pezzella F (Pezzella, Francesco Atrial fibrillation is associated with cardiac hypoxia CARDIOVASCULAR PATHOLOGY Volume: 19 Issue: 2 Pages: 102-111 Published: MAR-APR 2010 Carlin S (Carlin, Sean)1,2, Khan N (Khan, Nahida)1, Ku T (Ku, Thomas)1, Longo VA (Longo, Valerie A.)1, Larson SM (Larson, Steve M.)1, Smith-Jones PM (Smith-Jones, Peter M. Molecular Targeting of Carbonic Anhydrase IX in Mice with Hypoxic HT29 Colorectal Tumor Xenografts PLOS ONE Volume: 5 Issue: 5 Article Number: e10857 Published: MAY 27 2010 Shao YG (Shao, Yangguang), Li Y (Li, Yan), Zhang J (Zhang, Jian), Liu D (Liu, Di), Liu FR (Liu, Furong), Zhao Y (Zhao, Yue), Shen T (Shen, Tao), Li F (Li, Feng Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX NUCLEIC ACIDS RESEARCH Volume: 38 Issue: 9 Pages: 2813-2824 Published: MAY 2010 Poulsen SA : Carbonic anhydrase inhibition as a cancer therapy: a review of patent literature, 2007-2009 EXPERT OPINION ON THERAPEUTIC PATENTS Volume: 20 Issue: 6 Pages: 795-806 Published: JUN 2010 Brzozowski Z (Brzozowski, Zdzislaw)2, Slawinski J (Slawinski, Jaroslaw)1, Saczewski F (Saczewski, Franciszek)2, Innocenti A (Innocenti, Alessio)3, Supuran CT (Supuran, Claudiu T. Carbonic anhydrase inhibitors: Synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 45 Issue: 6 Pages: 2396-2404 Published: JUN 2010 Ilie M (Ilie, M.)1,2, Mazure NM (Mazure, N. M.)3,4, Hofman V (Hofman, V.)1,2,5, Ammadi RE (Ammadi, R. E.)6, Ortholan C (Ortholan, C.)7, Bonnetaud C (Bonnetaud, C.)5, Havet K (Havet, K.)1, Venissac N (Venissac, N.)2,8, Mograbi B (Mograbi, B.)2, Mouroux J (Mouroux, J.)2,8, Pouyssegur J (Pouyssegur, J.)3,4, Hofman P (Hofman, P High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer BRITISH JOURNAL OF CANCER Volume: 102 Issue: 11 Pages: 1627-1635 Published: MAY 25 2010 Montani M (Montani, Matteo)1, Heinimann K (Heinimann, Karl)2, von Teichman A (von Teichman, Adriana)1, Rudolph T (Rudolph, Thomas)1, Perren A (Perren, Aurel)3, Moch H (Moch, Holger) VHL-gene Deletion in Single Renal Tubular Epithelial Cells and Renal Tubular Cysts: Further Evidence for a Cyst-dependent Progression Pathway of Clear Cell Renal Carcinoma in von Hippel-Lindau Disease AMERICAN JOURNAL OF SURGICAL PATHOLOGY Volume: 34 Issue: 6 Pages: 806-815 Published: JUN 2010 Chiche J, Brahimi-Horn MC, Pouyssegur J Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Volume: 14 Issue: 4 Pages: 771-794 Published: APR 2010 Schults MA (Schults, Marten A.)1, Timmermans L (Timmermans, Leen)1, Godschalk RW (Godschalk, Roger W.)1, Theys J (Theys, Jan)2, Wouters BG (Wouters, Bradly G.)3, van Schooten FJ (van Schooten, Frederik J.)1, Chiu RK (Chiu, Roland K Diminished Carcinogen Detoxification Is a Novel Mechanism for Hypoxia-inducible Factor 1-mediated Genetic Instability JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 285 Issue: 19 Pages: 14558-14564 Published: MAY 7 2010 Mees G (Mees, Gilles)7, Vangestel C (Vangestel, Christel)4, Dierckx R (Dierckx, Rudi)1,2,3,7, Pauwels P (Pauwels, Patrick)5, Van Meerbeeck J (Van Meerbeeck, Jan)6, Van de wiele C (Van de Wiele, Christophe) Carbonic Anhydrase IX Expression Correlates with FDG Uptake by Primary Non-Small Cell Lung Cancer CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS Volume: 25 Issue: 2 Pages: 149-154 Published: APR 2010 Cozier GE (Cozier, Gyles E.)1, Leese MP (Leese, Mathew P.)1, Lloyd MD (Lloyd, Matthew D.)1, Baker MD (Baker, Matthew D.)2, Thiyagarajan N (Thiyagarajan, Nethaji)2, Acharya KR (Acharya, K. Ravi)2, Potter BVL (Potter, Barry V. L.) Structures of Human Carbonic Anhydrase II/Inhibitor Complexes Reveal a Second Binding Site for Steroidal and Nonsteroidal Inhibitors BIOCHEMISTRY Volume: 49 Issue: 16 Pages: 3464-3476 Published: APR 27 2010 Abedalthagafi M (Abedalthagafi, Malak), Rushing EJ (Rushing, Elisabeth J.), Auerbach A (Auerbach, Aaron)1, Desouki MM (Desouki, Mohamed M.), Marwaha J (Marwaha, Jason), Wang ZF (Wang, Zengfeng), Fanburg-Smith JC (Fanburg-Smith, Julie C.) Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1 alpha: a histologic and immunohistochemical study of 45 cases ANNALS OF DIAGNOSTIC PATHOLOGY Volume: 14 Issue: 1 Pages: 15-22 Published: FEB 2010 Guler OO (Guler, O. Ozensoy)3, De Simone G (De Simone, G.)2, Supuran CT (Supuran, C. T Drug Design Studies of the Novel Antitumor Targets Carbonic Anhydrase IX and XII CURRENT MEDICINAL CHEMISTRY Volume: 17 Issue: 15 Pages: 1516-1526 Published: MAY 2010 Innocenti A (Innocenti, Alessio)3, Sarikaya SBO (Sarikaya, S. Beyza Oeztuerk)1, Gulcin I (Gulcin, Ilhami)1,2, Supuran CT (Supuran, Claudiu T Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids BIOORGANIC & MEDICINAL CHEMISTRY Volume: 18 Issue: 6 Pages: 2159-2164 Published: MAR 15 2010 Bertucci A (Bertucci, Anthony)2, Zoccola D (Zoccola, Didier)2, Tambutte S (Tambutte, Sylvie)2, Vullo D (Vullo, Daniela)1, Supuran CT (Supuran, Claudiu T.) Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines BIOORGANIC & MEDICINAL CHEMISTRY Volume: 18 Issue: 6 Pages: 2300-2303 Published: MAR 15 2010 Fijalkowska I (Fijalkowska, Iwona)1,2, Xu WL (Xu, Weiling)4,5, Comhair SAA (Comhair, Suzy A. A.)4,5, Janocha AJ (Janocha, Allison J.)4,5, Mavrakis LA (Mavrakis, Lori A.), Krishnamachary B (Krishnamachary, Balaji), Zhen LJ (Zhen, Lijie)1, Mao T (Mao, Thianzi)1, Richter A (Richter, Amy)1, Erzurum SC (Erzurum, Serpil C.), Tuder RM (Tuder, Rubin M.) Hypoxia Inducible-Factor1 alpha Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells AMERICAN JOURNAL OF PATHOLOGY Volume: 176 Issue: 3 Pages: 1130-1138 Published: MAR 2010 Heikkinen PT (Heikkinen, Pekka T.)3, Nummela M (Nummela, Marika), Leivonen SK (Leivonen, Suvi-Katri)4, Westermarck J (Westermarck, Jukka)5,6, Hill CS (Hill, Caroline S.)7, Kahari VM (Kahari, Veli-Matti)4,8, Jaakkola PM (Jaakkola, Panu M.) Hypoxia-activated Smad3-specific Dephosphorylation by PP2A JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 285 Issue: 6 Pages: 3740-3749 Published: FEB 5 2010 Vinas-Castells R (Vinas-Castells, Rosa), Beltran M (Beltran, Manuel), Valls G (Valls, Gabriela), Gomez I (Gomez, Irene)2, Garcia JM (Miguel Garcia, Jose)2, Montserrat-Sentis B (Montserrat-Sentis, Barbara)1, Baulida J (Baulida, Josep)1, Bonilla F (Bonilla, Felix)2, de Herreros AG (Garcia de Herreros, Antonio)1,3, Diaz VM (Diaz, Victor M. The Hypoxia-controlled FBXL14 Ubiquitin Ligase Targets SNAIL1 for Proteasome Degradation JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 285 Issue: 6 Pages: 3794-3805 Published: FEB 5 2010 Olive PL (Olive, Peggy L.)1, Banuelos CA (Banuelos, C. Adriana), Durand RE (Durand, Ralph E.), Kim JY (Kim, Joo-Young)2, Aquino-Parsons C (Aquino-Parsons, Christina) Endogenous and radiation-induced expression of gamma H2AX in biopsies from patients treated for carcinoma of the uterine cervix RADIOTHERAPY AND ONCOLOGY Volume: 94 Issue: 1 Pages: 82-89 Published: JAN 2010 Fang SW (Fang, Shengwei) Hong MT (Hong, Mei Tian)5, Zhang H (Zhang, Hong) Positron Emission Tomography Imaging of Tumor Hypoxia CURRENT MEDICAL IMAGING REVIEWS Volume: 6 Issue: 1 Pages: 8-16 Published: FEB 2010 Sansone P (Sansone, Pasquale)1,2, Piazzi G (Piazzi, Giulia)1,5, Paterini P (Paterini, Paola)1,4,5, Strillacci A (Strillacci, Antonio)4, Ceccarelli C (Ceccarelli, Claudio)5, Minni F (Minni, Francesco)6, Biasco G (Biasco, Guido)7, Chieco P (Chieco, Pasquale)1, Bonafe M (Bonafe, Massimiliano Cyclooxygenase-2/carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Volume: 13 Issue: 9B Pages: 3876-3887 Published: SEP 2010 Kennedy KM, Dewhirst MW Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation FUTURE ONCOLOGY Volume: 6 Issue: 1 Pages: 127-148 Published: JAN 2010 Touisni, N (Touisni, Nadia)1; Maresca, A (Maresca, Alfonso)2; McDonald, PC (McDonald, Paul C.)3,4; Lou, YM (Lou, Yuanmei)3,4; Scozzafava, A (Scozzafava, Andrea)2; Dedhar, S (Dedhar, Shoukat)3,4,5; Winum, JY (Winum, Jean-Yves)1; Supuran, CT (Supuran, Claudiu T.)2 Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors JOURNAL OF MEDICINAL CHEMISTRY Volume: 54 Issue: 24 Pages: 8271-8277 DOI: 10.1021/jm200983e Published: DEC 22 2011 Donato, DP (Donato, Daniel P.)1; Johnson, MT (Johnson, Matthew T.)2; Yang, XMJ (Yang, Ximing J.)3; Zynger, DL (Zynger, Debra L.)1 Expression of carbonic anhydrase IX in genitourinary and adrenal tumours HISTOPATHOLOGY Volume: 59 Issue: 6 Pages: 1229-1239 DOI: 10.1111/j.1365-2559.2011.04074.x Published: DEC 2011 Asakawa, C (Asakawa, Chiharu)1; Ogawa, M (Ogawa, Masanao)1,2; Kumata, K (Kumata, Katsushi)1; Fujinaga, M (Fujinaga, Masayuki)1; Yamasaki, T (Yamasaki, Tomoteru)1; Xie, L (Xie, Lin)1; Yui, J (Yui, Joji)1; Kawamura, K (Kawamura, Kazunori)1; Fukumura, T (Fukumura, Toshimitsu)1; Zhang, MR (Zhang, Ming-Rong)1 Radiosynthesis of three [(11)C]ureido-substituted benzenesulfonamides as PET probes for carbonic anhydrase IX in tumors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 21 Issue: 23 Pages: 7017-7020 DOI: 10.1016/j.bmcl.2011.09.102 Published: DEC 1 2011 Zhou, WY (Zhou, Wenyu)1,5; Dosey, TL (Dosey, Timothy L.)2,5; Biechele, T (Biechele, Travis)3,5; Moon, RT (Moon, Randall T.)3,5; Horwitz, MS (Horwitz, Marshall S.)1,4,5; Ruohola-Baker, H (Ruohola-Baker, Hannele)1,2,5 Assessment of Hypoxia Inducible Factor Levels in Cancer Cell Lines upon Hypoxic Induction Using a Novel Reporter Construct PLOS ONE Volume: 6 Issue: 11 Article Number: e27460 DOI: 10.1371/journal.pone.0027460 Published: NOV 23 2011 Mellor, HR (Mellor, Howard R.)1; Callaghan, R (Callaghan, Richard)1 Accumulation and distribution of doxorubicin in tumour spheroids: the influence of acidity and expression of P-glycoprotein CANCER CHEMOTHERAPY AND PHARMACOLOGY Volume: 68 Issue: 5 Pages: 1179-1190 DOI: 10.1007/s00280-011-1598-8 Published: NOV 2011 Guedj, N (Guedj, Nathalie)1; Bretagnol, F (Bretagnol, Frederic)2; Rautou, PE (Rautou, Pierre-Emmanuel)3; Deschamps, L (Deschamps, Lydia); Cazals-Hatem, D (Cazals-Hatem, Dominique); Bedossa, P (Bedossa, Pierre); Panis, Y (Panis, Yves)2; Couvelard, A (Couvelard, Anne) Predictors of tumor response after preoperative chemoradiotherapy for rectal adenocarcinomas HUMAN PATHOLOGY Volume: 42 Issue: 11 Pages: 1702-1709 DOI: 10.1016/j.humpath.2011.01.015 Published: NOV 2011 Fu, LP (Fu, Leiping)1,4; Wang, G (Wang, Gang)1,4; Shevchuk, MM (Shevchuk, Maria M.)2,4; Nanus, DM (Nanus, David M.)3,4; Gudas, LJ (Gudas, Lorraine J.)1,4 Generation of a Mouse Model of Von Hippel-Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1 alpha CANCER RESEARCH Volume: 71 Issue: 21 Pages: 6848-6856 DOI: 10.1158/0008-5472.CAN-11-1745 Published: NOV 1 2011 Zhang, J (Zhang, Jing)2; Zhang, J (Zhang, Jun)1; Fan, YY (Fan, Yingying)1; Liu, LH (Liu, Lihong)2; Li, MJ (Li, Mengjie)2; Zhou, Y (Zhou, Yang)1; Shao, ZH (Shao, Zhihua)1; Shi, HJ (Shi, Hongjun)1; Wang, Y (Wang, Ying)2 Identification of Differentially Expressed Genes in Lung Tissues of Nickel-Exposed Rats Using Suppression Subtractive Hybridization BIOLOGICAL TRACE ELEMENT RESEARCH Volume: 143 Issue: 2 Pages: 1007-1017 DOI: 10.1007/s12011-010-8898-4 Published: NOV 2011 Birner, P (Birner, Peter)1; Jesch, B (Jesch, Bettina); Friedrich, J (Friedrich, Julia)1; Riegler, M (Riegler, Martin); Zacherl, J (Zacherl, Johannes); Hejna, M (Hejna, Michael)2; Wrba, F (Wrba, Fritz)1; Schultheis, A (Schultheis, Andrea)3; Schoppmann, SF (Schoppmann, Sebastian F.)4 Carbonic Anhydrase IX Overexpression is Associated with Diminished Prognosis in Esophageal Cancer and Correlates with Her-2 Expression ANNALS OF SURGICAL ONCOLOGY Volume: 18 Issue: 12 Pages: 3330-3337 DOI: 10.1245/s10434-011-1730-3 Published: NOV 2011 Marushima, H (Marushima, Hideki)1,4; Shibata, SI (Shibata, Shun-Ichi)1; Asakura, T (Asakura, Tadashi)1; Matsuura, T (Matsuura, Tomokazu)2; Maehashi, H (Maehashi, Haruka)2; Ishii, Y (Ishii, Yuji)4; Eda, H (Eda, Homare)1; Aoki, K (Aoki, Katsuhiko)1; Iida, Y (Iida, Yasushi)3; Morikawa, T (Morikawa, Toshiaki)4; Ohkawa, K (Ohkawa, Kiyoshi)1 Three-dimensional culture promotes reconstitution of the tumor-specific hypoxic microenvironment under TGF beta stimulation INTERNATIONAL JOURNAL OF ONCOLOGY Volume: 39 Issue: 5 Pages: 1327-1336 DOI: 10.3892/ijo.2011.1142 Published: NOV 2011 Salmon, AJ (Salmon, Adam J.)2; Williams, ML (Williams, Michael L.)2; Maresca, A (Maresca, Alfonso)1; Supuran, CT (Supuran, Claudiu T.)1; Poulsen, SA (Poulsen, Sally-Ann Synthesis of glycoconjugate carbonic anhydrase inhibitors by ruthenium-catalysed azide-alkyne 1,3-dipolar cycloaddition BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 21 Issue: 20 Pages: 6058-6061 DOI: 10.1016/j.bmcl.2011.08.066 Published: OCT 15 2011 Morris, JC (Morris, Jason C.)1; Chiche, J (Chiche, Johanna)3; Grellier, C (Grellier, Caroline)1; Lopez, M (Lopez, Marie)1; Bornaghi, LF (Bornaghi, Laurent F.)1; Maresca, A (Maresca, Alfonso)2; Supuran, CT (Supuran, Claudiu T.)2; Pouyssegur, J (Pouyssegur, Jacques)3; Poulsen, SA (Poulsen, Sally-Ann)1 Targeting Hypoxic Tumor Cell Viability with Carbohydrate-Based Carbonic Anhydrase IX and XIII Inhibitors JOURNAL OF MEDICINAL CHEMISTRY Volume: 54 Issue: 19 Pages: 6905-6918 DOI: 10.1021/jm200892s Published: OCT 13 2011 Proescholdt, M (Proescholdt, Martin)1; Merrill, M (Merrill, Marsha)3; Stoerr, EM (Stoerr, Eva-Maria)1; Lohmeier, A (Lohmeier, Annette)1; Dietmaier, W (Dietmaier, Wolfgang)2; Brawanski, A (Brawanski, Alexander)1 Expression of carbonic anhydrase IX in craniopharyngiomas Laboratory investigation JOURNAL OF NEUROSURGERY Volume: 115 Issue: 4 Pages: 796-801 DOI: 10.3171/2011.6.JNS1168 Published: OCT 2011 Neri Dario; Supuran Claudiu T. Interfering with pH regulation in tumours as a therapeutic strategy NATURE REVIEWS DRUG DISCOVERY Volume: 10 Issue: 10 Pages: 767-777 DOI: 10.1038/nrd3554 Published: OCT 2011 Pinheiro, C (Pinheiro, Celine)1,2; Sousa, B (Sousa, Barbara)3; Albergaria, A (Albergaria, Andre)1,3; Paredes, J (Paredes, Joana)3; Dufloth, R (Dufloth, Rozany)4; Vieira, D (Vieira, Daniella)5; Schmitt, F (Schmitt, Fernando)3,6; Baltazar, F (Baltazar, Fatima)1,2 GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression HISTOLOGY AND HISTOPATHOLOGY Volume: 26 Issue: 10 Pages: 1279-1286 Published: OCT 2011 Knaus, EE (Knaus, Edward E.)2; Innocenti, A (Innocenti, Alessio)1; Scozzafava, A (Scozzafava, Andrea)1; Supuran, CT (Supuran, Claudiu T.)1 Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 21 Issue: 19 Pages: 5892-5896 DOI: 10.1016/j.bmcl.2011.07.090 Published: OCT 1 2011 Olbryt, M (Olbryt, Magdalena)1,4; Habryka, A (Habryka, Anna)1,5; Tyszkiewicz, T (Tyszkiewicz, Tomasz)2; Rusin, A (Rusin, Aleksandra)1; Cichon, T (Cichon, Tomasz)1; Jarzab, M (Jarzab, Michal)1,3; Krawczyk, Z (Krawczyk, Zdzislaw)1,5 Melanoma-associated genes, MXI1, FN1, and NME1, are hypoxia responsive in murine and human melanoma cells MELANOMA RESEARCH Volume: 21 Issue: 5 Pages: 417-425 DOI: 10.1097/CMR.0b013e328348db2f Published: OCT 2011 El Guerrab, A (El Guerrab, Abderrahim)1,2; Zegrour, R (Zegrour, Rabah)2; Nemlin, CC (Nemlin, Carine-Christiane)2; Vigier, F (Vigier, Flavie)2; Cayre, A (Cayre, Anne)3; Penault-Llorca, F (Penault-Llorca, Frederique)3; Rossignol, F (Rossignol, Fabrice)2; Bignon, YJ (Bignon, Yves-Jean)1 Differential Impact of EGFR-Targeted Therapies on Hypoxia Responses: Implications for Treatment Sensitivity in Triple-Negative Metastatic Breast Cancer PLOS ONE Volume: 6 Issue: 9 Article Number: e25080 DOI: 10.1371/journal.pone.0025080 Published: SEP 22 2011 Dungwa Josiah V.; Hunt Linda P.; Ramani Pramila Overexpression of carbonic anhydrase and HIF-1 alpha in Wilms tumours BMC CANCER Volume: 11 Article Number: 390 DOI: 10.1186/1471-2407-11-390 Published: SEP 12 2011 El-Sayed, NS (El-Sayed, Nadia S.)1; El-Bendary, ER (El-Bendary, Eman R.)1; El-Ashry, SM (El-Ashry, Saadia M.)1; El-Kerdawy, MM (El-Kerdawy, Mohammed M.)1 Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo [3,2-a]pyrimidines EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 46 Issue: 9 Pages: 3714-3720 DOI: 10.1016/j.ejmech.2011.05.037 Published: SEP 2011 Langhammer, S (Langhammer, Stefan)1; Najjar, M (Najjar, Maher)2; Hess-Stumpp, H (Hess-Stumpp, Holger)2; Thierauch, KH (Thierauch, Karl-Heinz)2 LDH-A influences hypoxia-inducible factor 1 alpha (HIF1 alpha) and is critical for growth of HT29 colon carcinoma cells in vivo TARGETED ONCOLOGY Volume: 6 Issue: 3 Pages: 155-162 DOI: 10.1007/s11523-011-0184-7 Published: SEP 2011 Beketic-Oreskovic, L (Beketic-Oreskovic, Lidija)1; Ozretic, P (Ozretic, Petar)2; Rabbani, ZN (Rabbani, Zahid N.)3; Jackson, IL (Jackson, Isabel L.)3; Sarcevic, B (Sarcevic, Bozena)4; Levanat, S (Levanat, Sonja)2; Maric, P (Maric, Petra)1; Babic, I (Babic, Ivan)5; Vujaskovic, Z (Vujaskovic, Zeljko)3 Prognostic Significance of Carbonic Anhydrase IX (CA-IX), Endoglin (CD105) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in Breast Cancer Patients PATHOLOGY & ONCOLOGY RESEARCH Volume: 17 Issue: 3 Pages: 593-603 DOI: 10.1007/s12253-010-9355-6 Published: SEP 2011 Rice, SL (Rice, Samuel L.); Roney, CA (Roney, Celeste A.); Daumar, P (Daumar, Pierre); Lewis, JS (Lewis, Jason S.)1,2 The Next Generation of Positron Emission Tomography Radiopharmaceuticals in Oncology SEMINARS IN NUCLEAR MEDICINE Volume: 41 Issue: 4 Pages: 265-282 DOI: 10.1053/j.semnuclmed.2011.02.002 Published: JUL 2011 Nyhan, MJ (Nyhan, Michelle J.)1; El Mashad, SM (El Mashad, Shereen M.)1; O'Donovan, TR (O'Donovan, Tracey R.)1; Ahmad, S (Ahmad, Sarfraz)1,2; Collins, C (Collins, Chris)1; Sweeney, P (Sweeney, Paul)2; Rogers, E (Rogers, Eamonn)2; O'Sullivan, GC (O'Sullivan, Gerald C.)1,2; McKenna, SL (McKenna, Sharon L.)1 VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin CELLULAR ONCOLOGY Volume: 34 Issue: 3 Pages: 225-234 DOI: 10.1007/s13402-011-0029-5 Published: JUN 2011 Onishi, H (Onishi, Hideya)1; Kai, M (Kai, Masaya)1; Odate, S (Odate, Seiichi)1; Iwasaki, H (Iwasaki, Hironori)1; Morifuji, Y (Morifuji, Yoshihiro)1; Ogino, T (Ogino, Toshitatsu)1; Morisaki, T (Morisaki, Takafumi)1; Nakashima, Y (Nakashima, Yutaka)2; Katano, M (Katano, Mitsuo)1 Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer CANCER SCIENCE Volume: 102 Issue: 6 Pages: 1144-1150 DOI: 10.1111/j.1349-7006.2011.01912.x Published: JUN 2011 Sun, XL (Sun, Xilin)1,2; Niu, G (Niu, Gang)1,3; Chan, N (Chan, Nicholas)1; Shen, BZ (Shen, Baozhong)2; Chen, XY (Chen, Xiaoyuan)1 Tumor Hypoxia Imaging MOLECULAR IMAGING AND BIOLOGY Volume: 13 Issue: 3 Pages: 399-410 DOI: 10.1007/s11307-010-0420-z Published: JUN 2011 Rami, M (Rami, Marouan)1; Maresca, A (Maresca, Alfonso)2; Smaine, FZ (Smaine, Fatma-Zhora)1,3; Montero, JL (Montero, Jean-Louis)1; Scozzafava, A (Scozzafava, Andrea)2; Winum, JY (Winum, Jean-Yves)1; Supuran, CT (Supuran, Claudiu T.)2 Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 21 Issue: 10 Pages: 2975-2979 DOI: 10.1016/j.bmcl.2011.03.055 Published: MAY 15 2011 Lou, YM (Lou, Yuanmei)1; McDonald, PC (McDonald, Paul C.)1; Oloumi, A (Oloumi, Arusha)1; Chia, S (Chia, Stephen)2; Ostlund, C (Ostlund, Christina)1; Ahmadi, A (Ahmadi, Ardalan)1; Kyle, A (Kyle, Alastair)1; Keller, UAD (Keller, Ulrich Auf Dem)6; Leung, S (Leung, Samuel)8; Huntsman, D (Huntsman, David)3,8; Clarke, B (Clarke, Blaise)8,9; Sutherland, BW (Sutherland, Brent W.)4; Waterhouse, D (Waterhouse, Dawn)4; Bally, M (Bally, Marcel)4; Roskelley, C (Roskelley, Calvin)7; Overall, CM (Overall, Christopher M.)6; Minchinton, A (Minchinton, Andrew)1; Pacchiano, F (Pacchiano, Fabio)10; Carta, F (Carta, Fabrizio)10; Scozzafava, A (Scozzafava, Andrea)10; Touisni, N (Touisni, Nadia)11; Winum, JY (Winum, Jean-Yves)11; Supuran, CT (Supuran, Claudiu T.)10; Dedhar, S (Dedhar, Shoukat)1, Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors CANCER RESEARCH Volume: 71 Issue: 9 Pages: 3364-3376 ,2011 Shin, HJ (Shin, Hye-Jin)1; Rho, SB (Rho, Seung Bae)1; Jung, DC (Jung, Dae Chul)1; Han, IO (Han, Inn-Oc)2; Oh, ES (Oh, Eok-Soo)3,4; Kim, JY (Kim, Joo-Young)1 Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion JOURNAL OF CELL SCIENCE Volume: 124 Issue: 7 Pages: 1077-1087 DOI: 10.1242/jcs.072207 Published: APR 1 2011 Ilie, MI (Ilie, Marius I.)1,2,3; Hofman, V (Hofman, Veronique)1,2,3,4; Ortholan, C (Ortholan, Cecile)3,5; El Ammadi, R (El Ammadi, Reda)3,6; Bonnetaud, C (Bonnetaud, Christelle)4; Havet, K (Havet, Katia)1; Venissac, N (Venissac, Nicolas)1,3,7; Mouroux, J (Mouroux, Jerome)1,3,7; Mazure, NM (Mazure, Nathalie M.)3,8,9; Pouyssegur, J (Pouyssegur, Jacques)3,8,9; Hofman, P (Hofman, Paul)1,2,3,4 Overexpression of carbonic anhydrase XII in tissues from resectable non-small cell lung cancers is a biomarker of good prognosis INTERNATIONAL JOURNAL OF CANCER Volume: 128 Issue: 7 Pages: 1614-1623 DOI: 10.1002/ijc.25491 Published: APR 1 2011 Pacchiano, F (Pacchiano, Fabio)3; Carta, F (Carta, Fabrizio)3; McDonald, PC (McDonald, Paul C.)1,2; Lou, YM (Lou, Yuanmei)1,2; Vullo, D (Vullo, Daniela)3; Scozzafava, A (Scozzafava, Andrea)3; Dedhar, S (Dedhar, Shoukat)1,2,4; Supuran, CT (Supuran, Claudiu T.)3 Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis JOURNAL OF MEDICINAL CHEMISTRY Volume: 54 Issue: 6 Pages: 1896-1902 DOI: 10.1021/jm101541x Published: MAR 24 2011 Wind, TC (Wind, Tobias C.)1,2; Messenger, MP (Messenger, Michael P.)1,2; Thompson, D (Thompson, Douglas)1,2; Selby, PJ (Selby, Peter J.)1; Banks, RE (Banks, Rosamonde E.)1 Measuring carbonic anhydrase IX as a hypoxia biomarker: differences in concentrations in serum and plasma using a commercial enzyme-linked immunosorbent assay due to influences of metal ions ANNALS OF CLINICAL BIOCHEMISTRY Volume: 48 Pages: 112-120 DOI: 10.1258/acb.2010.010240 Part: Part 2 Published: MAR 2011 Cassavaugh, J (Cassavaugh, Jessica)1; Lounsbury, KM (Lounsbury, Karen M.)1 Hypoxia-Mediated Biological Control JOURNAL OF CELLULAR BIOCHEMISTRY Volume: 112 Issue: 3 Pages: 735-744 DOI: 10.1002/jcb.22956 Published: MAR 2011 Busk, M (Busk, Morten)1; Toustrup, K (Toustrup, Kasper)1; Sorensen, BS (Sorensen, Brita S.)1; Alsner, J (Alsner, Jan)1; Horsman, MR (Horsman, Michael R.)1; Jakobsen, S (Jakobsen, Steen)2; Overgaard, J (Overgaard, Jens)1 In vivo Identification and Specificity assessment of mRNA markers of hypoxia in human and mouse tumors BMC CANCER Volume: 11 Article Number: 63 DOI: 10.1186/1471-2407-11-63 Published: FEB 9 2011 Schelter, F (Schelter, Florian)1; Halbgewachs, B (Halbgewachs, Birgit)1; Baumler, P (Baeumler, Petra)1; Neu, C (Neu, Caroline)1; Gorlach, A (Goerlach, Agnes)2; Schrotzlmair, F (Schroetzlmair, Florian)1; Kruger, A (Krueger, Achim)1 Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by hypoxia-inducible factor-1 alpha CLINICAL & EXPERIMENTAL METASTASIS Volume: 28 Issue: 2 Pages: 91-99 DOI: 10.1007/s10585-010-9360-x Published: FEB 2011 Salinas A. 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Relation to histological type and tumoral progression" ACTAS UROLOGICAS ESPANOLAS Volume: 35 Issue: 2 Pages: 87-88 DOI: 10.1016/j.acuro.2010.12.001 Published: FEB 2011 Parks Scott K.; Chiche Johanna; Pouyssegur Jacques pH Control Mechanisms of Tumor Survival and Growth JOURNAL OF CELLULAR PHYSIOLOGY Volume: 226 Issue: 2 Pages: 299-308 DOI: 10.1002/jcp.22400 Published: FEB 2011 Nakamura, J (Nakamura, Jun)1; Kitajima, Y (Kitajima, Yoshihiko)1; Kai, K (Kai, Keita)1,2; Hashiguchi, K (Hashiguchi, Kazuyoshi)1; Hiraki, M (Hiraki, Masatsugu)1; Noshiro, H (Noshiro, Hirokazu)1; Miyazaki, K (Miyazaki, Kohji)1 Expression of Hypoxic Marker CA IX Is Regulated by Site-Specific DNA Methylation and Is Associated with the Histology of Gastric Cancer AMERICAN JOURNAL OF PATHOLOGY Volume: 178 Issue: 2 Pages: 515-524 DOI: 10.1016/j.ajpath.2010.10.010 Published: FEB 2011 Liao, SY (Liao, S-Y)1; Rodgers, WH (Rodgers, W. H.)2; Kauderer, J (Kauderer, J.)3; Bonfiglio, TA (Bonfiglio, T. A.)4; Darcy, KM (Darcy, K. M.)3; Carter, R (Carter, R.)3; Levine, L (Levine, L.)5; Spirtos, NM (Spirtos, N. M.)6,7; Susumu, N (Susumu, N.)8; Fujiwara, K (Fujiwara, K.)9; Walker, JL (Walker, J. L.)10; Hatae, M (Hatae, M.)9; Stanbridge, EJ (Stanbridge, E. J.)11 Carbonic anhydrase IX (CA-IX) and high-risk human papillomavirus (H-HPV) as diagnostic biomarkers of cervical dysplasia/neoplasia in Japanese women with a cytologic diagnosis of atypical glandular cells (AGC): a Gynecologic Oncology Group (GOG) Study BRITISH JOURNAL OF CANCER Volume: 104 Issue: 2 Pages: 353-360 DOI: 10.1038/sj.bjc.6606049 Published: JAN 18 2011 Woelber, L (Woelber, Linn)1; Kress, K (Kress, Kerstin)1; Kersten, JF (Kersten, Jan F.)2; Choschzick, M (Choschzick, Matthias)3; Kilic, E (Kilic, Ergin)3; Herwig, U (Herwig, Uwe)4; Lindner, C (Lindner, Christoph)5; Schwarz, J (Schwarz, Joerg)1,6; Jaenicke, F (Jaenicke, Fritz)1; Mahner, S (Mahner, Sven)1; Milde-Langosch, K (Milde-Langosch, Karin)1; Mueller, V (Mueller, Volkmar)1; Ihnen, M (Ihnen, Maike)1 Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer BMC CANCER Volume: 11 Article Number: 12 DOI: 10.1186/1471-2407-11-12 Published: JAN 11 2011 Zhang, SY (Zhang, Shenyi)1; Yang, CM (Yang, Chunmei)1; Lu, WQ (Lu, Weiqiang)1; Huang, J (Huang, Jin)1; Zhu, WP (Zhu, Weiping)1; Li, HL (Li, Honglin)1; Xu, YF (Xu, Yufang)1; Qian, XH (Qian, Xuhong)1 A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging CHEMICAL COMMUNICATIONS Volume: 47 Issue: 29 Pages: 8301-8303 DOI: 10.1039/c1cc12386f Published: 2011 Verratti, V (Verratti, V.)1; Brunetti, L (Brunetti, L.)2; Tenaglia, R (Tenaglia, R.)3; Chiavaroli, A (Chiavaroli, A.)2; Ferrante, C (Ferrante, C.)2; Leone, S (Leone, S.)2; Orlando, G (Orlando, G.)2; Berardinelli, F (Berardinelli, F.)3; Di Giulio, C (Di Giulio, C.)1; Vacca, M (Vacca, M.)2 PHYSIOLOGICAL ANALYSIS OF 8-ISO-PGF2 ALPHA: A HOMEOSTATIC AGENT IN SUPERFICIAL BLADDER CANCER JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS Volume: 25 Issue: 1 Pages: 71-76 Published: JAN-MAR 2011 Hackenbeck, T (Hackenbeck, Thomas)2; Huber, R (Huber, Regina)2; Schietke, R (Schietke, Ruth)2; Knaup, KX (Knaup, Karl X.); Monti, J (Monti, Juliana)2; Wu, XQ (Wu, Xiaoqing)2; Klanke, B (Klanke, Bernd); Frey, B (Frey, Benjamin)3; Gaipl, U (Gaipl, Udo)3; Wullich, B (Wullich, Bernd)4; Ferbus, D (Ferbus, Didier)5; Goubin, G (Goubin, Gerard)5; Warnecke, C (Warnecke, Christina); Eckardt, KU (Eckardt, Kai-Uwe); Wiesener, MS (Wiesener, Michael S.)1,2 The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH Volume: 1813 Issue: 1 Pages: 1-13 DOI: 10.1016/j.bbamcr.2010.10.019 Published: JAN 2011 Mathupala Saroj P. 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Hif-1 as a target for cancer chemotherapy, chemosensitization and chemoprevention Current Molecular Pharmacology 4 (1) , pp. 62-77 , 2011 Albert, S (Albert, Sebastien)[ 1,2,3 ] ; Hourseau, M (Hourseau, Muriel)[ 4 ] ; Halimi, C (Halimi, Caroline)[ 1,2,3 ] ; Serova, M (Serova, Maria)[ 1,2,5 ] ; Descatoire, V (Descatoire, Veronique)[ 4 ] ; Barry, B (Barry, Beatrix)[ 3 ] ; Couvelard, A (Couvelard, Anne)[ 4 ] ; Riveiro, ME (Riveiro, Maria Eugenia)[ 1,2 ] ; Tijeras-Raballand, A (Tijeras-Raballand, Annemilai)[ 5 ] ; de Gramont, A (de Gramont, Armand)[ 5 ] ; Raymond, E (Raymond, Eric)[ 1,2 ] ; Faivre, S (Faivre, Sandrine)[ 1,2 ] Prognostic value of the chemokine receptor CXCR4 and epithelial-to-mesenchymal transition in patients with squamous cell carcinoma of the mobile tongue ORAL ONCOLOGY Volume: 48 Issue: 12 Pages: 1263-1271 DOI: 10.1016/j.oraloncology.2012.06.010 Published: DEC 2012 Icard, Philippe; Lincet, Hubert A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER Volume: 1826 Issue: 2 Pages: 423-433 DOI: 10.1016/j.bbcan.2012.07.001 Published: DEC 2012 Kaya, AO (Kaya, A. 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Microtissue size and hypoxia in HTS with 3D cultures DRUG DISCOVERY TODAY Volume: 17 Issue: 15-16 Pages: 810-817 DOI: 10.1016/j.drudis.2012.03.004 Published: AUG 2012 Fromy, B (Fromy, Berengere)[ 4,5 ] ; Lingueglia, E (Lingueglia, Eric)[ 1,2,3 ] ; Sigaudo-Roussel, D (Sigaudo-Roussel, Dominique)[ 4,5 ] ; Saumet, JL (Saumet, Jean Louis)[ 4,5 ] ; Lazdunski, M (Lazdunski, Michel)[ 1,2 ] Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers NATURE MEDICINE Volume: 18 Issue: 8 Pages: 1205-+ DOI: 10.1038/nm.2844 Published: AUG 2012 Winum, JY (Winum, Jean-Yves)[ 2 ] ; Carta, F (Carta, Fabrizio)[ 1 ] ; Ward, C (Ward, Carol)[ 3,4 ] ; Mullen, P (Mullen, Peter)[ 3,4 ] ; Harrison, D (Harrison, David)[ 5 ] ; Langdon, SP (Langdon, Simon P.)[ 3,4 ] ; Cecchi, A (Cecchi, Alessandro)[ 1 ] ; Scozzafava, A (Scozzafava, Andrea)[ 1 ] ; Kunkler, I (Kunkler, Ian)[ 6 ] ; Supuran, CT (Supuran, Claudiu T.) Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 22 Issue: 14 Pages: 4681-4685 DOI: 10.1016/j.bmcl.2012.05.083 Published: JUL 15 2012 Singh, Shalini A QSAR Study on Novel Series of Carbonic Anhydrase Inhibitors hCA IX-Tumor-Associated (Hypoxia) MEDICINAL CHEMISTRY Volume: 8 Issue: 4 Pages: 656-672 Published: JUL 2012 Li, GR (Li, Guorong)[ 1 ] ; Bilal, I (Bilal, Issam)[ 1 ] ; Gentil-Perret, A (Gentil-Perret, Anne)[ 2 ] ; Feng, G (Feng, Gang); Zhao, A (Zhao, An)[ 1 ] ; Peoc'h, M (Peoc'h, Michel)[ 2 ] ; Genin, C (Genin, Christian); Tostain, J (Tostain, Jacques)[ 1 ] ; Gigante, M (Gigante, Marc)[ 1 ] CA9 as a molecular marker for differential diagnosis of cystic renal tumors UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS Volume: 30 Issue: 4 Pages: 463-468 DOI: 10.1016/j.urolonc.2010.04.014 Published: JUL-AUG 2012 Williams, E (Williams, Emma)[ 1 ] ; Martin, S (Martin, Stewart)[ 2 ] ; Moss, R (Moss, Robert)[ 2 ] ; Durrant, L (Durrant, Lindy)[ 2 ] ; Deen, S (Deen, Suha)[ 1 ] Co-expression of VEGF and CA9 in ovarian high-grade serous carcinoma and relationship to survival VIRCHOWS ARCHIV Volume: 461 Issue: 1 Pages: 33-39 DOI: 10.1007/s00428-012-1252-9 Published: JUL 2012 Onishi, H (Onishi, Hideya)[ 1 ] ; Morifuji, Y (Morifuji, Yoshihiro)[ 1 ] ; Kai, M (Kai, Masaya)[ 1 ] ; Suyama, K (Suyama, Kumi)[ 1 ] ; Iwasaki, H (Iwasaki, Hironori)[ 1 ] ; Katano, M (Katano, Mitsuo)[ 1 ] Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer CANCER SCIENCE Volume: 103 Issue: 7 Pages: 1272-1279 DOI: 10.1111/j.1349-7006.2012.02297.x Published: JUL 2012 Xu, Q (Xu, Qian)[ 1,2 ] ; Guo, HL (Guo, Hongling)[ 1 ] ; Zhang, XJ (Zhang, Xiaojie)[ 1 ] ; Tang, BS (Tang, Beisha)[ 2 ] ; Cai, F (Cai, Fang)[ 1 ] ; Zhou, WH (Zhou, Weihui)[ 3,4 ] ; Song, WH (Song, Weihong)[ 1,3,4 ] Hypoxia regulation of ATP13A2 (PARK9) gene transcription JOURNAL OF NEUROCHEMISTRY Volume: 122 Issue: 2 Pages: 251-259 DOI: 10.1111/j.1471-4159.2012.07676.x Published: JUL 2012 Gaur, S (Gaur, Shikha)[ 1 ] ; Chen, LL (Chen, Linling)[ 1 ] ; Yen, T (Yen, Terence)[ 1 ] ; Wang, YF (Wang, Yafan)[ 1 ] ; Zhou, BS (Zhou, Bingsen)[ 1 ] ; Davis, M (Davis, Mark)[ 2 ] ; Yen, Y (Yen, Yun)[ 1 ] Preclinical study of the cyclodextrin-polymer conjugate of camptothecin CRLX101 for the treatment of gastric cancer NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE Volume: 8 Issue: 5 Pages: 721-730 DOI: 10.1016/j.nano.2011.09.007 Published: JUL 2012 Salmon, AJ (Salmon, Adam J.)[ 1 ] ; Wiliams, ML (Wiliams, Michael L.)[ 1 ] ; Wu, QK (Wu, Quoc K.)[ 2 ] ; Morizzi, J (Morizzi, Julia)[ 2 ] ; Gregg, D (Gregg, Daniel)[ 2 ] ; Charman, SA (Charman, Susan A.)[ 2 ] ; Vullo, D (Vullo, Daniela)[ 3 ] ; Supuran, CT (Supuran, Claudiu T.)[ 3 ] ; Poulsen, SA (Poulsen, Sally-Ann) Metallocene-Based Inhibitors of Cancer-Associated Carbonic Anhydrase Enzymes IX and XII JOURNAL OF MEDICINAL CHEMISTRY Volume: 55 Issue: 11 Pages: 5506-5517 DOI: 10.1021/jm300427m Published: JUN 14 2012 Gieling, RG (Gieling, Roben G.)[ 2 ] ; Babur, M (Babur, Muhammad)[ 2 ] ; Mamnani, L (Mamnani, Lupti)[ 2 ] ; Burrows, N (Burrows, Natalie)[ 2 ] ; Telfer, BA (Telfer, Brian A.)[ 2 ] ; Carta, F (Carta, Fabrizio)[ 1 ] ; Winum, JY (Winum, Jean-Yves)[ 3 ] ; Scozzafava, A (Scozzafava, Andrea)[ 1 ] ; Supuran, CT (Supuran, Claudiu T.)[ 1 ] ; Williams, KJ (Williams, Kaye J.) Antimetastatic Effect of Sulfamate Carbonic Anhydrase IX Inhibitors in Breast Carcinoma Xenografts JOURNAL OF MEDICINAL CHEMISTRY Volume: 55 Issue: 11 Pages: 5591-5600 DOI: 10.1021/jm300529u Published: JUN 14 2012 Singh, Shalini In Silico Modeling of Carbonic Anhydrase Inhibitor hCA IX-Tumor Associated (Hypoxia) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES INDIA SECTION A-PHYSICAL SCIENCES Volume: 82 Issue: 2 Pages: 113-123 DOI: 10.1007/s40010-012-0018-8 Published: JUN 2012 Rana, S (Rana, Shoaib)[ 1,2 ] ; Nissen, F (Nissen, Felix)[ 3 ] ; Marr, A (Marr, Annabell)[ 2,3 ] ; Markert, A (Markert, Annette)[ 2,3 ] ; Altmann, A (Altmann, Annette)[ 2,3 ] ; Mier, W (Mier, Walter)[ 3 ] ; Debus, J (Debus, Juergen)[ 1 ] ; Haberkorn, U (Haberkorn, Uwe)[ 2,3 ] ; Askoxylakis, V (Askoxylakis, Vasileios)[ 1,2 ] Optimization of a Novel Peptide Ligand Targeting Human Carbonic Anhydrase IX PLOS ONE Volume: 7 Issue: 5 Article Number: e38279 DOI: 10.1371/journal.pone.0038279 Published: MAY 31 2012 Delay, M (Delay, Michael)[ 1 ] ; Jahangiri, A (Jahangiri, Arman)[ 1 ] ; Carbonell, WS (Carbonell, W. 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P.)[ 1,2 ] ; Bordoli, MR (Bordoli, M. R.)[ 1,2 ] ; Abreu-Rodriguez, I (Abreu-Rodriguez, I.)[ 1,2 ] ; Wollenick, K (Wollenick, K.)[ 1,2 ] ; Schraml, P (Schraml, P.)[ 3 ] ; Gradin, K (Gradin, K.)[ 4 ] ; Poellinger, L (Poellinger, L.)[ 4,5 ] ; Kristiansen, G (Kristiansen, G.)[ 6 ] ; Wenger, RH (Wenger, R. H.)[ 1,2 ] Non-canonical HIF-2 alpha function drives autonomous breast cancer cell growth via an AREG-EGFR/ErbB4 autocrine loop ONCOGENE Volume: 31 Issue: 18 Pages: 2283-2297 DOI: 10.1038/onc.2011.417 Published: MAY 2012 Chien, MH (Chien, Ming-Hsien)[ 3 ] ; Ying, TH (Ying, Tsung-Ho)[ 4,5 ] ; Hsieh, YH (Hsieh, Yi-Hsien)[ 6 ] ; Lin, CH (Lin, Chien-Huang)[ 7 ] ; Shih, CH (Shih, Chun-Han)[ 2 ] ; Wei, LH (Wei, Lin-Hung)[ 8 ] ; Yang, SF (Yang, Shun-Fa)[ 1,9 ] Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis ORAL ONCOLOGY Volume: 48 Issue: 5 Pages: 417-423 DOI: 10.1016/j.oraloncology.2011.11.015 Published: MAY 2012 Lastraioli, E (Lastraioli, Elena)[ 1 ] ; Bencini, L (Bencini, Lapo); Bianchini, E (Bianchini, Elisa)[ 2 ] ; Romoli, MR (Romoli, Maria Raffaella)[ 1 ] ; Crociani, O (Crociani, Olivia)[ 1 ] ; Giommoni, E (Giommoni, Elisa)[ 3 ] ; Messerini, L (Messerini, Luca)[ 4 ] ; Gasperoni, S (Gasperoni, Silvia)[ 3 ] ; Moretti, R (Moretti, Renato); Di Costanzo, F (Di Costanzo, Francesco)[ 3 ] ; Boni, L (Boni, Luca)[ 2 ] ; Arcangeli, A (Arcangeli, Annarosa)[ 1 ] hERG1 Channels and Glut-1 as Independent Prognostic Indicators of Worse Outcome in Stage I and II Colorectal Cancer: A Pilot Study TRANSLATIONAL ONCOLOGY Volume: 5 Issue: 2 Pages: 105-112 DOI: 10.1593/tlo.11250 Published: APR 2012 Sherman, TA (Sherman, Teresa A.)[ 1 ] ; Rongali, SC (Rongali, Sharath C.)[ 1 ] ; Matthews, TA (Matthews, Tori A.)[ 1 ] ; Pfeiffer, J (Pfeiffer, Jason)[ 1 ] ; Nehrke, K (Nehrke, Keith) Identification of a nuclear carbonic anhydrase in Caenorhabditis elegans BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH Volume: 1823 Issue: 4 Pages: 808-817 DOI: 10.1016/j.bbamcr.2011.12.014 Published: APR 2012 Hu, YL (Hu, Yu-Long)[ 1 ] ; DeLay, M (DeLay, Michael)[ 1 ] ; Jahangiri, A (Jahangiri, Arman)[ 1 ] ; Molinaro, AM (Molinaro, Annette M.)[ 1 ] ; Rose, SD (Rose, Samuel D.)[ 1 ] ; Carbonell, WS (Carbonell, W. 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L.)[ 2,7 ] Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification BRITISH JOURNAL OF CANCER Volume: 106 Issue: 5 Pages: 916-922 DOI: 10.1038/bjc.2012.32 Published: FEB 28 2012 Carta, F (Carta, Fabrizio)[ 1 ] ; Aggarwal, M (Aggarwal, Mayank)[ 2 ] ; Maresca, A (Maresca, Alfonso)[ 1 ] ; Scozzafava, A (Scozzafava, Andrea)[ 1 ] ; McKenna, R (McKenna, Robert)[ 2 ] ; Masin, E (Masin, Emanuela)[ 3 ] ; Supuran, CT (Supuran, Claudiu T.)[ 1 ] Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo JOURNAL OF MEDICINAL CHEMISTRY Volume: 55 Issue: 4 Pages: 1721-1730 DOI: 10.1021/jm300031j Published: FEB 23 2012 Schilling, D (Schilling, Daniela) Bayer, C (Bayer, Christine)[ 1 ] ; Li, W (Li, Wei)[ 3 ] ; Molls, M (Molls, Michael)[ 1 ] ; Vaupel, P (Vaupel, Peter)[ 1 ] ; Multhoff, G (Multhoff, Gabriele)[ 1,2 ] Radiosensitization of Normoxic and Hypoxic H1339 Lung Tumor Cells by Heat Shock Protein 90 Inhibition Is Independent of Hypoxia Inducible Factor-1 alpha PLOS ONE Volume: 7 Issue: 2 Article Number: e31110 DOI: 10.1371/journal.pone.0031110 Published: FEB 7 2012 Pinheiro, C (Pinheiro, Celine)[ 1,2 ] ; Longatto, A (Longatto-Filho, Adhemar)[ 1,2,3 ] ; Azevedo-Silva, J (Azevedo-Silva, Joao)[ 4 ] ; Casal, M (Casal, Margarida)[ 4 ] ; Schmitt, FC (Schmitt, Fernando C.)[ 5,6 ] ; Baltazar, F (Baltazar, Fatima) Role of monocarboxylate transporters in human cancers: state of the art JOURNAL OF BIOENERGETICS AND BIOMEMBRANES Volume: 44 Issue: 1 Pages: 127-139 DOI: 10.1007/s10863-012-9428-1 Published: FEB 2012 Monti, S. M.; Supuran, C. T.; De Simone, G. Carbonic Anhydrase IX as a Target for Designing Novel Anticancer Drugs CURRENT MEDICINAL CHEMISTRY Volume: 19 Issue: 6 Pages: 821-830 Published: FEB 2012 Petrul, HM (Petrul, Heike M.)[ 1 ] ; Schatz, CA (Schatz, Christoph A.)[ 1 ] ; Kopitz, CC (Kopitz, Charlotte C.)[ 1 ] ; Adnane, L (Adnane, Lila)[ 1 ] ; McCabe, TJ (McCabe, Timothy J.)[ 1 ] ; Trail, P (Trail, Pamela)[ 1 ] ; Ha, S (Ha, Sha)[ 1 ] ; Chang, YS (Chang, Yong S.)[ 1 ] ; Voznesensky, A (Voznesensky, Andrei)[ 1 ] ; Ranges, G (Ranges, Gerald)[ 1 ] ; Tamburini, PP (Tamburini, Paul P.)[ 1 ] Therapeutic Mechanism and Efficacy of the Antibody-Drug Conjugate BAY 79-4620 Targeting Human Carbonic Anhydrase 9 MOLECULAR CANCER THERAPEUTICS Volume: 11 Issue: 2 Pages: 340-349 DOI: 10.1158/1535-7163.MCT-11-0523 Published: FEB 2012 Salinas-Sanchez, AS (Salinas-Sanchez, A. S.)[ 1 ] ; Gimenez-Bachs, JM (Gimenez-Bachs, J. 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Generation of anti-tumour immune response using dendritic cells pulsed with carbonic anhydrase IX-Acinetobacter baumannii outer membrane protein A fusion proteins against renal cell carcinoma CLINICAL AND EXPERIMENTAL IMMUNOLOGY Volume: 167 Issue: 1 Pages: 73-83 DOI: 10.1111/j.1365-2249.2011.04489.x Published: JAN 2012 Tafreshi, NK (Tafreshi, Narges K.)[ 1 ] ; Bui, MM (Bui, Marilyn M.)[ 2,3,5 ] ; Bishop, K (Bishop, Kellsey)[ 1 ] ; Lloyd, MC (Lloyd, Mark C.)[ 3 ] ; Enkemann, SA (Enkemann, Steven A.)[ 4 ] ; Lopez, AS (Lopez, Alexis S.)[ 2 ] ; Abrahams, D (Abrahams, Dominique)[ 6 ] ; Carter, BW (Carter, Bradford W.)[ 5 ] ; Vagner, J (Vagner, Josef)[ 7 ] ; Gobmyer, SR (Gobmyer, Stephen R.)[ 8 ] ; Gillies, RJ (Gillies, Robert J.)[ 1 ] ; Morse, DL (Morse, David L.)[ 1 ] Noninvasive Detection of Breast Cancer Lymph Node Metastasis Using Carbonic Anhydrases IX and XII Targeted Imaging Probes CLINICAL CANCER RESEARCH Volume: 18 Issue: 1 Pages: 207-219 DOI: 10.1158/1078-0432.CCR-11-0238 Published: JAN 1 2012 Reuben, SC (Reuben, Sharon C.)[ 2 ] ; Gopalan, A (Gopalan, Ashwin)[ 2 ] ; Petit, DM (Petit, Danielle M.)[ 2 ] ; Bishayee, A (Bishayee, Anupam) Modulation of angiogenesis by dietary phytoconstituents in the prevention and intervention of breast cancer MOLECULAR NUTRITION & FOOD RESEARCH Volume: 56 Issue: 1 Pages: 14-29 DOI: 10.1002/mnfr.201100619 Published: JAN 2012 Błaszczak-Światkiewicz, K., Olszewska, P., Mikiciuk-Olasik, Wpływ hipoksji na zmiany metabolizmu komórek nowotworowych | [Effects of hypoxia on tumor metabolism] Nowotwory 62 (4) , pp. 283-290, 2012 Deschamps, L.a, Bacha, D.a, Rebours, V.be, Mebarki, M.c, Bretagnol, F.d, Panis, Y.de, Bedossa, P.ae, Ruszniewski, P.be, Couvelard, A.aef The expression of the hypoxia markers CA9 and CXCR4 is correlated with survival in patients with neuroendocrine tumours of the ileum Neuroendocrinology , Volume 95, Issue 3, April 2012, Pages 214-222, 2012 Matsubara, T.a , DiResta, G.R.b, Kakunaga, S.c, Li, D.d, Healey, J.H. Additive influence of extracellular pH, oxygen tension, and pressure on invasiveness and survival of human osteosarcoma cells Frontiers in Oncology Volume 3 JUL, 2013, Article number 00199 Doyen, J.ab, Parks, S.K.a, Marcié, S.b, Pouysségur, J.ac, Chiche, J. Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis Frontiers in Oncology Volume 2 JAN, 2013, Article number Article 00199 Carroux, C.J.a, Rankin, G.M.a, Moeker, J.a, Bornaghi, L.F.a, Katneni, K.b, Morizzi, J.b, Charman, S.A.b, Vullo, D.c, Supuran, C.T.c , Poulsen, S.-A. A prodrug approach toward cancer-related carbonic anhydrase inhibition Journal of Medicinal Chemistry Volume 56, Issue 23, 12 December 2013, Pages 9623-9634 Honasoge, A., Sontheimer, H. Involvement of tumor acidification in brain cancer pathophysiology Frontiers in Physiology Volume 4 NOV, 2013, Article number Article 316 Kawai, Y., Kaidoh, M., Yokoyama, Y., Ohhashi, T. Cell surface F1/Fo ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues American Journal of Physiology - Cell Physiology Volume 305, Issue 11, 1 December 2013, Pages C1139-C1150 Taddei, M.L.a, Giannoni, E.a, Comito, G.a, Chiarugi, P. Cancer Letters Volume 341, Issue 1, 28 November 2013, Pages 80-96 Wandzilak, A.a , Czyzycki, M.ab, Wrobel, P.a, Szczerbowska-Boruchowska, M.a, Radwanska, E.c, Adamek, D.c, Lankosz, M. The oxidation states and chemical environments of iron and zinc as potential indicators of brain tumour malignancy grade-preliminary results Metallomics Volume 5, Issue 11, November 2013, Pages 1547-1553 Gondi, G.a, Mysliwietz, J.b, Hulikova, A.d, Jen, J.P.d, Swietach, P.d, Kremmer, E.b, Zeidler, R. Antitumor efficacy of a monoclonal antibody that inhibits the activity of cancer-associated carbonic anhydrase XII Cancer Research Volume 73, Issue 21, 1 November 2013, Pages 6494-6503 Shareef, M.M.ab , Udayakumar, T.S.ab, Sinha, V.K.abc, Saleem, S.M.d, Griggs, W.W. Interaction of HIF-1α and Notch3 Is Required for the Expression of Carbonic Anhydrase 9 in Breast Carcinoma Cells Genes and Cancer Volume 4, Issue 11-12, November 2013, Pages 513-523 Rana, S.abc, Nissen, F.abc, Lindner, T.abc, Altmann, A.abc, Mier, W.abc, Debus, J.abc, Haberkorn, U.abc, Askoxylakis, V. Screening of a novel peptide targeting the proteoglycan-Like region of human carbonic anhydrase 9 Molecular Imaging Volume 12, Issue 8, November 2013 Santi, A.a , Caselli, A.a , Paoli, P.a , Corti, D.a , Camici, G.a , Pieraccini, G.b , Taddei, M.L.a , Serni, S.c , Chiarugi, P.a , Cirri, P. The effects of CA IX catalysis products within tumor microenvironment Cell Communication and Signaling Volume 11, Issue 1, 2013, Article number 81 Zerati, M.ab , Leite, K.R.M.ab, Pontes-Junior, J.ab, Segre, C.C.ab, Reis, S.T.ab, Srougi, M.ab, Dall'Oglio, M.F. Carbonic anhydrase IX is not a predictor of outcomes in non-metastatic clear cell renal cell carcinoma - a digital analysis of tissue microarray International Braz J Urol Volume 39, Issue 4, 2013, Pages 484-492 Klimowicz, A.C.abe, Bose, P.a, Petrillo, S.K.b, Magliocco, A.M.abf, Dort, J.C.c , Brockton, N.T. The prognostic impact of a combined carbonic anhydrase IX and Ki67 signature in oral squamous cell carcinoma British Journal of Cancer Volume 109, Issue 7, 1 October 2013, Pages 1859-1866 Sudhakar, J.ab, Venkatesan, N.ab, Lakshmanan, S.a, Khetan, V.b, Krishnakumar, S.a, Biswas, J. Hypoxic tumor microenvironment in advanced retinoblastoma Pediatric Blood and Cancer Volume 60, Issue 10, October 2013, Pages 1598-1601 Patel, N.R., Pattni, B.S., Abouzeid, A.H., Torchilin, V.P. Nanopreparations to overcome multidrug resistance in cancer Advanced Drug Delivery Reviews Volume 65, Issue 13-14, 2013, Pages 1748-1762 Larkin, S.a , Kyprianou, N. Molecular signatures in urologic tumors International Journal of Molecular Sciences Volume 14, Issue 9, 6 September 2013, Pages 18421-18436 Czepluch, F.S.a, Schlegel, M.a, Bremmer, F.b, Behnes, C.L.b, Hasenfuss, G.a, Schäfer, K. Stage-dependent detection of CD14+ and CD16+ cells in the human heart after myocardial infarction Virchows Archiv Volume 463, Issue 3, September 2013, Pages 459-469 Rademakers, S.E.a , Hoogsteen, I.J.a, Rijken, P.F.a, Oosterwijk, E.b, Terhaard, C.H.c, Doornaert, P.A.d, Langendijk, J.A.e, Van Den Ende, P.f, Takes, R.g, De Bree, R.h, Van Der Kogel, A.J.a, Bussink, J.a, Kaanders, J.H. Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial Radiotherapy and Oncology Volume 108, Issue 3, September 2013, Pages 517-522 Parks, S.K.a, Chiche, J.b, Pouysségur, J. Disrupting proton dynamics and energy metabolism for cancer therapy Nature Reviews Cancer Volume 13, Issue 9, September 2013, Pages 611-623 Said, H.M. Determination human brain tumor marker gene carbonic anhydrase 9 (CA9) gene expression in different type of brain tumor cell 2013 ICME International Conference on Complex Medical Engineering, CME 2013 2013, Article number 6548278, Pages 403-407 Vadlapatla, R.K., Vadlapudi, A.D., Mitra, A.K. Hypoxia-inducible factor-1 (HIF-1): A potential target for intervention in ocular neovascular diseases Current Drug Targets Volume 14, Issue 8, 2013, Pages 919-935 Xu, K.ac, Mao, X.a, Mehta, M.ad, Cui, J.a, Zhang, C.a, Mao, F.a, Xu, Y. Elucidation of How Cancer Cells Avoid Acidosis through Comparative Transcriptomic Data Analysis PLoS ONE Volume 8, Issue 8, 14 August 2013, Article number e71177 Miranda, E.a, Nordgren, I.K.a, Male, A.L.a, Lawrence, C.E.a, Hoakwie, F.a, Cuda, F.a, Court, W.d, Fox, K.R.bc, Townsend, P.A.cef, Packham, G.K.ce, Eccles, S.A.d, Tavassoli, A. A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells Journal of the American Chemical Society Volume 135, Issue 28, 17 July 2013, Pages 10418-10425 de Theije, C.C.ab, Langen, R.C.J.ac, Lamers, W.H.ab, Schols, A.M.W.J.ac, Köhler, S.E. Distinct responses of protein turnover regulatory pathways in hypoxia- and semistarvation-induced muscle atrophy American Journal of Physiology - Lung Cellular and Molecular Physiology Volume 305, Issue 1, 1 July 2013, Pages L82-L91 Yingjun, G., Xun, Q. Acid-sensing ion channels under hypoxia Channels Volume 7, Issue 4, July 2013, Pages 231-237 Said, H.M.a , Hagemann, C.b, Carta, F.c, Katzer, A.a, Polat, B.a, Staab, A.d, Scozzafava, A.c, Anacker, J.e, Vince, G.H.bf, Flentje, M.a, Supuran, C.T. Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including Acetazolamide in human Glioblastoma Bioorganic and Medicinal Chemistry Volume 21, Issue 13, 1 July 2013, Pages 3949-3957 Zhu, Y.ac, Zhou, X.-Y.bc, Yao, X.-D.ac, Zhang, S.-L.ac, Dai, B.ac, Zhang, H.-L.ac, Shen, Y.-J.ac, Ye, D.-W. Prognostic value of carbonic anhydrase IX expression in penile squamous cell carcinoma: A pilot study Urologic Oncology: Seminars and Original Investigations Volume 31, Issue 5, July 2013, Pages 706-711 Wang, Z.-C., Qin, Y.-J., Wang, P.-F., Yang, Y.-A., Wen, Q., Zhang, X., Qiu, H.-Y., Duan, Y.-T., Wang, Y.-T., Sang, Y.-L., Zhu, H.-L. Sulfonamides containing coumarin moieties selectively and potently inhibit carbonic anhydrases II and IX: Design, synthesis, inhibitory activity and 3D-QSAR analysis European Journal of Medicinal Chemistry Volume 66, 2013, Pages 1-11 Fiaschi, T.a, Giannoni, E.a, Taddei, M.L.a, Cirri, P.a, Marini, A.b, Pintus, G.b, Nativi, C.c, Richichi, B.c, Scozzafava, A.c, Carta, F.d, Torre, E.a, Supuran, C.T.d, Chiarugi, P. Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells Cell Cycle Volume 12, Issue 11, 1 June 2013, Pages 1791-1801 Lounnas, N.ab, Rosilio, C.ab, Nebout, M.ab, Mary, D.ab, Griessinger, E.ab, Neffati, Z.ab, Chiche, J.bc, Spits, H.d, Hagenbeek, T.J.e, Asnafi, V.f, Poulsen, S.-A.g, Supuran, C.T.h, Peyron, J.-F.abij , Imbert, V. Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas Cancer Letters Volume 333, Issue 1, 1 June 2013, Pages 76-88 Gary-Bobo, M.ad, Vaillant, O.a, Maynadier, M.a, Basile, I.a, Gallud, A.a, El Cheikh, K.a, Bouffard, E.a, Morére, A.ad, Rébillard, X.ab, Puche, P.ac, Nirdé, P.a, Garcia, M. Targeting multiplicity: The key factor for anti-cancer nanoparticles Current Medicinal Chemistry Volume 20, Issue 15, May 2013, Pages 1946-1955 Ece, H.a , Mehmet, E.a, Cigir, B.A.b, Yavuz, D.b, Muammer, K.a, Cumhur, G.b, Mustafa, H.c, Sevki, C.a, Fusun, S.a, Gokhan, O.A. Serum 8-OHdG and HIF-1aa levels: Do they affect the development of malignancy in patients with hypoactive thyroid nodules? Wspolczesna Onkologia Volume 17, Issue 1, 2013, Pages 51-57 Goyal, R., Gersbach, E., Yang, X.J., Rohan, S.M. Differential diagnosis of renal tumors with clear cytoplasm: Clinical relevance of renal tumor subclassification in the era of targeted therapies and personalized medicine Archives of Pathology and Laboratory Medicine Volume 137, Issue 4, April 2013, Pages 467-480 Burroughs, S.K.a, Kaluz, S.b, Wang, D.a, Wang, K.a, Van Meir, E.G.b, Wang, B. Hypoxia inducible factor pathway inhibitors as anticancer therapeutics Future Medicinal Chemistry Volume 5, Issue 5, April 2013, Pages 553-572 Winum, J.-Y.a , Colinas, P.A.b, Supuran, C.T. Glycosidic carbonic anhydrase IX inhibitors: A sweet approach against cancer Bioorganic and Medicinal Chemistry Volume 21, Issue 6, 15 March 2013, Pages 1419-1426 Zhao, Y.a, Butler, E.B.b, Tan, M. Targeting cellular metabolism to improve cancer therapeutics Cell Death and Disease Volume 4, Issue 3, March 2013, Pages e532 Liao, S.Y.a, Rodgers, W.H.b, Kauderer, J.c, Darcy, K.M.c, Carter, R.c, Susumu, N.d, Nagao, S.e, Walker, J.L.f, Hatae, M.g, Stanbridge, E.J. Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: A Gynaecological Oncology Group Study British Journal of Cancer Volume 108, Issue 3, 19 February 2013, Pages 613-620 Maruyama, T.ab, Miyamoto, Y.a , Yamamoto, G.c, Yamada, A.a, Yoshimura, K.a, Suzawa, T.a, Takami, M.a, Akiyama, T.ab, Hoshino, M.ab, Iwasa, F.b, Ikumi, N.a, Tachikawa, T.c, Mishima, K.c, Baba, K.b, Kamijo, R. Downregulation of Carbonic Anhydrase IX Promotes Col10a1 Expression in Chondrocytes PLoS ONE Volume 8, Issue 2, 18 February 2013, Article number e56984 Teppo, S.a, Sundquist, E.a, Vered, M.b, Holappa, H.c, Parkkisenniemi, J.a, Rinaldi, T.a, Lehenkari, P.d, Grenman, R.e, Dayan, D.b, Risteli, J.fg, Salo, T.ag, Nyberg, P. The hypoxic tumor microenvironment regulates invasion of aggressive oral carcinoma cells Experimental Cell Research Volume 319, Issue 4, 15 February 2013, Pages 376-389 van der Groep, P.ab , van Diest, P.J.a, Smolders, Y.H.C.M.a, Ausems, M.G.E.M.c, van der Luijt, R.B.c, Menko, F.H.d, Bart, J.e, de Vries, E.G.E.f, van der Wall, E. HIF-1α Overexpression in Ductal Carcinoma In Situ of the Breast in BRCA1 and BRCA2 Mutation Carriers PLoS ONE Volume 8, Issue 2, 8 February 2013, Article number e56055 Povoski, S.P. , Hall, N.C., Murrey, D.A., Sharp, D.S., Hitchcock, C.L., Mojzisik, C.M., Bahnson, E.E., Knopp, M.V., Martin, E.W., Bahnson, R.R. Multimodal imaging and detection strategy with 124 I-labeled chimeric monoclonal antibody cG250 for accurate localization and confirmation of extent of disease during laparoscopic and open surgical resection of clear cell renal cell carcinoma Surgical Innovation Volume 20, Issue 1, February 2013, Pages 59-69 Lu, G., Hillier, S.M., Maresca, K.P., Zimmerman, C.N., Eckelman, W.C., Joyal, J.L., Babich, J.W. Synthesis and SAR of novel Re/99mTc-Labeled benzenesulfonamide carbonic anhydrase IX inhibitors for molecular imaging of tumor hypoxia Journal of Medicinal Chemistry Volume 56, Issue 2, 24 January 2013, Pages 510-520 Shan, X.ab, Wang, D.a , Chen, J.b, Xiao, X.b, Jiang, Y.a, Wang, Y.b, Fan, Y. Necrosis degree displayed in computed tomography images correlated with hypoxia and angiogenesis in breast cancer Journal of Computer Assisted Tomography Volume 37, Issue 1, January 2013, Pages 22-28 Slawinski, J (Slawinski, Jaroslaw)[ 1 ] ; Szafranski, K (Szafranski, Krzysztof)[ 1 ] ; Vullo, D (Vullo, Daniela)[ 2 ] ; Supuran, CT Carbonic anhydrase inhibitors. Synthesis of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives and their inhibition of the human cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 69 Pages: 701-710, 2013 Guo Yingjun; Qu Xun Acid-sensing ion channels under hypoxia CHANNELS Volume: 7 Issue: 4 Pages: 231-237 Published: JUL 1 2013 Monti, Simona Maria; Supuran, Claudiu T.; De Simone, Giuseppina Anticancer carbonic anhydrase inhibitors: a patent review (2008-2013) EXPERT OPINION ON THERAPEUTIC PATENTS Volume: 23 Issue: 6 Pages: 737-749 Published: JUN 2013 Aggarwal, M (Aggarwal, Mayank)[ 1 ] ; Boone, CD (Boone, Christopher D.)[ 1 ] ; Kondeti, B (Kondeti, Bhargav)[ 1 ] ; McKenna, R Structural annotation of human carbonic anhydrases JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Volume: 28 Issue: 2 Pages: 267-277, 2013 SitaRam (SitaRam)[ 1 ] ; Ceruso, M (Ceruso, Mariangela)[ 2,3 ] ; Khloya, P (Khloya, Poonam)[ 1 ] ; Supuran, CT (Supuran, Claudiu T.)[ 2,3 ] ; Sharma, PK 4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII BIOORGANIC & MEDICINAL CHEMISTRY Volume: 22 Issue: 24 Pages: 6945-6952 , 2014 Fais, Stefano; Venturi, Giulietta; Gatenby, Bob Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy CANCER AND METASTASIS REVIEWS Volume: 33 Issue: 4 Special Issue: SI Pages: 1095-1108 Published: DEC 2014 Cai, CY (Cai, Chunyu)[ 1 ] ; Alshehri, A (Alshehri, Ali)[ 2 ] ; Choksi, R (Choksi, Rati)[ 2 ] ; Pestronk, A Regional Ischemic Immune Myopathy: A Paraneoplastic Dermatomyopathy OURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY Volume: 73 Issue: 12 Pages: 1126-1133, 2014 Chen, YH (Chen, Yuhan)[ 1 ] ; Li, XM (Li, Xianming)[ 1 ] ; Wu, SH (Wu, Shihai)[ 1 ] ; Xu, G (Xu, Gang)[ 1 ] ; Zhou, YY (Zhou, Yayan)[ 1 ] ; Gong, L (Gong, Long)[ 1 ] ; Li, ZH (Li, Zihuang)[ 1 ] ; Yang, D Expression of HIF-1 alpha and CAIX in nasopharyngeal carcinoma and their correlation with patients' prognosis MEDICAL ONCOLOGY Volume: 31 Issue: 12, Article Number: 304, 2014 Stewart, GD (Stewart, Grant D.)[ 1,2 ] ; O'Mahony, FC (O'Mahony, Fiach C.)[ 1,2 ] ; Laird, A (Laird, Alexander)[ 1,2,4 ] ; Rashid, S (Rashid, Sukaina)[ 3 ] ; Martin, SA (Martin, Sarah A.)[ 3 ] ; Eory, L (Eory, Lel)[ 4 ] ; Lubbock, ALR (Lubbock, Alexander L. R.)[ 4 ] ; Nanda, J (Nanda, Jyoti)[ 1,2 ] ; O'Donnell, M (O'Donnell, Marie)[ 1,2 ] ; Mackay, A (Mackay, Alan)[ 5 ] ; Mullen, P (Mullen, Peter)[ 6 ] ; McNeill, SA (McNeill, S. Alan)[ 1,2 ] ; Riddick, ACP (Riddick, Antony C. P.)[ 1,2 ] ; Aitchison, M (Aitchison, Michael)[ 2,7 ] ; Berney, D (Berney, Daniel)[ 3 ] ; Bex, A (Bex, Axel)[ 8 ] ; Overton, IM (Overton, Ian M.)[ 4 ] ; Harrison, DJ (Harrison, David J.)[ 1,2,6 ] ; Powles, T Carbonic Anhydrase 9 Expression Increases with Vascular Endothelial Growth Factor-Targeted Therapy and Is Predictive of Outcome in Metastatic Clear Cell Renal Cancer EUROPEAN UROLOGY Volume: 66 Issue: 5 Pages: 956-963, 2014 Bryant, JL (Bryant, J. L.)[ 1,2 ] ; Meredith, SL (Meredith, S. L.)[ 2 ] ; Williams, KJ (Williams, K. J.)[ 2 ] ; White, A Targeting hypoxia in the treatment of small cell lung cancer LUNG CANCER Volume: 86 Issue: 2 Pages: 126-132, 2014 Sung, HY (Sung, Hye Youn)[ 1 ] ; Ju, W (Ju, Woong)[ 2 ] ; Ahn, JH DNA Hypomethylation-Mediated Overexpression of Carbonic Anhydrase 9 Induces an Aggressive Phenotype in Ovarian Cancer Cells YONSEI MEDICAL JOURNAL Volume: 55 Issue: 6 Pages: 1656-1663 Moeker, J (Moeker, Janina)[ 1 ] ; Mahon, BP (Mahon, Brian P.)[ 2 ] ; Bornaghi, LF (Bornaghi, Laurent F.)[ 1 ] ; Vullo, D (Vullo, Daniela)[ 3,4 ] ; Supuran, CT (Supuran, Claudiu T.)[ 3,4 ] ; McKenna, R (McKenna, Robert)[ 2 ] ; Poulsen, SA Structural Insights into Carbonic Anhydrase IX Isoform Specificity of Carbohydrate-Based Sulfamates JOURNAL OF MEDICINAL CHEMISTRY Volume: 57 Issue: 20 Pages: 8635-8645, 2014 Pinheiro, C (Pinheiro, Celine)[ 1,2,3,4 ] ; Garcia, EA (Garcia, Eduardo A.)[ 3,4 ] ; Morais-Santos, F (Morais-Santos, Filipa)[ 1,2 ] ; Scapulatempo-Neto, C (Scapulatempo-Neto, Cristovam)[ 4,5 ] ; Mafra, A (Mafra, Allini)[ 4 ] ; Steenbergen, RDM (Steenbergen, Renske D. M.)[ 6 ] ; Boccardo, E (Boccardo, Enrique)[ 7 ] ; Villa, LL (Villa, Luisa L.)[ 8,9,10 ] ; Baltazar, F (Baltazar, Fatima)[ 1,2 ] ; Longatto, A Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix BMC CANCER Volume: 14, Article Number: 751, 2014 Funahashi, Y (Funahashi, Yasuhiro)[ 1 ] ; Okamoto, K (Okamoto, Kiyoshi)[ 2 ] ; Adachi, Y (Adachi, Yusuke)[ 2 ] ; Semba, T (Semba, Taro)[ 2 ] ; Uesugi, M (Uesugi, Mai)[ 3 ] ; Ozawa, Y (Ozawa, Yoichi)[ 2 ] ; Tohyama, O (Tohyama, Osamu)[ 3 ] ; Uehara, T (Uehara, Taisuke)[ 3 ] ; Kimura, T (Kimura, Takayuki)[ 3 ] ; Watanabe, H (Watanabe, Hideki)[ 3 ] ; Asano, M (Asano, Makoto)[ 2 ] ; Kawano, S (Kawano, Satoshi)[ 2 ] ; Tizon, X (Tizon, Xavier)[ 4 ] ; McCracken, PJ (McCracken, Paul J.)[ 1 ] ; Matsui, J (Matsui, Junji)[ 2 ] ; Aoshima, K (Aoshima, Ken)[ 3 ] ; Nomoto, K (Nomoto, Kenichi)[ 5 ] ; Oda, Y Eribulin mesylate reduces tumor microenvironment abnormality by vascular remodeling in preclinical human breast cancer models CANCER SCIENCE Volume: 105 Issue: 10 Pages: 1334-1342, 2014 Gaur, S (Gaur, Shikha)[ 1 ] ; Wang, YF (Wang, Yafan)[ 2 ] ; Kretzner, L (Kretzner, Leo)[ 1 ] ; Chen, LL (Chen, Linling)[ 2 ] ; Yen, T (Yen, Terence)[ 2 ] ; Wu, XW (Wu, Xiwei)[ 3 ] ; Yuan, YC (Yuan, Yate-Ching)[ 3 ] ; Davis, M (Davis, Mark)[ 4 ] ; Yen, Y Pharmacodynamic and pharmacogenomic study of the nanoparticle conjugate of camptothecin CRLX101 for the treatment of cancer NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE Volume: 10 Issue: 7 Pages: 1477-1486, 2014 Walsh, JC (Walsh, Joseph C.)[ 1 ] ; Lebedev, A (Lebedev, Artem)[ 1 ] ; Aten, E (Aten, Edward)[ 2 ] ; Madsen, K (Madsen, Kathleen)[ 3 ] ; Marciano, L (Marciano, Liane)[ 2 ] ; Kolb, HC The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities ANTIOXIDANTS & REDOX SIGNALING Volume: 21 Issue: 10 Pages: 1516-1554, 2014 Doss, M (Doss, Mohan)[ 1 ] ; Kolb, HC (Kolb, Hartmuth C.)[ 2 ] ; Walsh, JC (Walsh, Joseph C.)[ 2 ] ; Mocharla, VP (Mocharla, Vani P.)[ 2 ] ; Zhu, ZH (Zhu, Zhihong)[ 3 ] ; Haka, M (Haka, Michael)[ 3 ] ; Alpaugh, RK (Alpaugh, R. Katherine)[ 4 ] ; Chen, DYT (Chen, David Y. T.)[ 5 ] ; Yu, JQ Biodistribution and Radiation Dosimetry of the Carbonic Anhydrase IX Imaging Agent [(18) F]VM4-037 Determined from PET/CT Scans in Healthy Volunteers MOLECULAR IMAGING AND BIOLOGY Volume: 16 Issue: 5 Pages: 739-746, 2014 Brinkhuizen, T (Brinkhuizen, Tjinta)[ 1,5 ] ; Weijzen, CAH (Weijzen, Chantal A. H.)[ 1,5 ] ; Eben, J (Eben, Jonathan)[ 2,5 ] ; Thissen, MR (Thissen, Monique R.)[ 1,5 ] ; van Marion, AM (van Marion, Arienne M.)[ 6 ] ; Lohman, BG (Lohman, Bjorn G.)[ 7 ] ; Winnepenninckx, VJL (Winnepenninckx, Veronique J. L.)[ 2,5 ] ; Nelemans, PJ (Nelemans, Patty J.)[ 3,5 ] ; van Steensel, MAM Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma PLOS ONE Volume: 9 Issue: 9, Article Number: e106427, 2014 Fan, H (Fan, H.)[ 1 ] ; Liu, F (Liu, F.)[ 1 ] ; Dong, G (Dong, G.)[ 1 ] ; Ren, D (Ren, D.)[ 1 ] ; Xu, Y (Xu, Y.)[ 1 ] ; Dou, J (Dou, J.)[ 1 ] ; Wang, T (Wang, T.)[ 1 ] ; Sun, L (Sun, L.)[ 2 ] ; Hou, Y Activation-induced necroptosis contributes to B-cell lymphopenia in active systemic lupus erythematosus CELL DEATH & DISEASE Volume: 5, Article Number: e1416, 2014 Miki, T (Miki, Takayuki)[ 1 ] ; Fujishima, S (Fujishima, Sho-hei)[ 1 ] ; Komatsu, K (Komatsu, Kazuhiro)[ 1 ] ; Kuwata, K (Kuwata, Keiko)[ 2 ] ; Kiyonaka, S (Kiyonaka, Shigeki)[ 1 ] ; Hamachi, I LDAI-Based Chemical Labeling of Intact Membrane Proteins and Its Pulse-Chase Analysis under Live Cell Conditions CHEMISTRY & BIOLOGY Volume: 21 Issue: 8 Pages: 1013-1022, 2014 Icard, P (Icard, Philippe)[ 1,2 ] ; Kafara, P (Kafara, Perrine)[ 2,3,4 ] ; Steyaert, JM (Steyaert, Jean-Marc)[ 1 ] ; Schwartz, L (Schwartz, Laurent)[ 1 ] ; Lincet, H The metabolic cooperation between cells in solid cancer tumors BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER Volume: 1846 Issue: 1 Pages: 216-225, 2014 Salman, S (Salman, Shaima)[ 1 ] ; Holloway, AC (Holloway, Alison C.)[ 2 ] ; Nurse, CA Chronic opioids regulate K-ATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2 alpha and protein kinase A AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY Volume: 307 Issue: 3 Pages: C266-C277 , 2014 Durdagi, S (Durdagi, Serdar)[ 1,2 ] ; Scozzafava, G (Scozzafava, Gabriele)[ 3 ] ; Vullo, D (Vullo, Daniela)[ 4 ] ; Sahin, H (Sahin, Huseyin)[ 5 ] ; Kolayli, S (Kolayli, Sevgi)[ 5 ] ; Supuran, CT Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Volume: 29 Issue: 4 Pages: 469-475, 2014 Sihver, L (Sihver, Lembit)[ 2,1 ] ; Ni, J (Ni, Jie)[ 3,1 ] ; Sun, L (Sun, Liang)[ 5,1,4 ] ; Kong, D (Kong, Dong)[ 1 ] ; Ren, YY (Ren, Yuanyuan)[ 1 ] ; Gu, SY Voxel model of individual cells and its implementation in microdosimetric calculations using GEANT4 ADIATION AND ENVIRONMENTAL BIOPHYSICS Volume: 53 Issue: 3 Pages: 571-579, 2014 Ward, JBJ (Ward, Joseph B. J.)[ 1 ] ; Keely, SJ (Keely, Simon J.)[ 2 ] ; Keely, SJ Oxygen in the regulation of intestinal epithelial transport JOURNAL OF PHYSIOLOGY-LONDON Volume: 592 Issue: 12 Pages: 2473-2489, 2014 Gits, CMM (Gits, Caroline M. M.)[ 1 ] ; van Kuijk, PF (van Kuijk, Patricia F.)[ 1 ] ; de Rijck, JCWM (de Rijck, Jonneke C. W. M.)[ 1 ] ; Muskens, N (Muskens, Nikky)[ 1 ] ; Jonkers, MBE (Jonkers, Moniek B. E.)[ 1 ] ; van IJcken, WF (van IJcken, Wilfred F.)[ 2 ] ; Mathijssen, RHJ (Mathijssen, Ron H. J.)[ 1 ] ; Verweij, J (Verweij, Jaap)[ 1 ] ; Sleijfer, S (Sleijfer, Stefan)[ 1 ] ; Wiemer, EAC MicroRNA response to hypoxic stress in soft tissue sarcoma cells: microRNA mediated regulation of HIF3 alpha BMC CANCER Volume: 14, Article Number: 429, 2014 Mariani, CJ (Mariani, Christopher J.)[ 1,2 ] ; Vasanthakumar, A (Vasanthakumar, Aparna)[ 1 ] ; Madzo, J (Madzo, Jozef)[ 1 ] ; Yesilkanal, A (Yesilkanal, Ali)[ 3 ] ; Bhagat, T (Bhagat, Tushar)[ 4 ] ; Yu, Y (Yu, Yiting)[ 4 ] ; Bhattacharyya, S (Bhattacharyya, Sanchari)[ 4 ] ; Wenger, RH (Wenger, Roland H.)[ 5,6 ] ; Cohn, SL (Cohn, Susan L.)[ 7 ] ; Nanduri, J (Nanduri, Jayasri)[ 8,9 ] ; Verma, A (Verma, Amit)[ 4 ] ; Prabhakar, NR (Prabhakar, Nanduri R.)[ 8,9 ] ; Godley, LA TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction inNeuroblastoma CELL REPORTS Volume: 7 Issue: 5 Pages: 1343-1352, 2014 O'Shannessy, DJ (O'Shannessy, Daniel J.)[ 1 ] ; Somers, EB (Somers, Elizabeth B.)[ 1 ] ; Chandrasekaran, LK (Chandrasekaran, Lakshmi K.)[ 2 ] ; Nicolaides, NC (Nicolaides, Nicholas C.)[ 1 ] ; Bordeaux, J (Bordeaux, Jennifer)[ 2 ] ; Gustavson, MD Influence of tumor microenvironment on prognosis in colorectal cancer: tissue architecture-dependent signature of endosialin (TEM-1) and associated proteins ONCOTARGET Volume: 5 Issue: 12 Pages: 3983-3995, 2014 Chhajed, M (Chhajed, Mahavir)[ 1 ] ; Shrivastava, AK (Shrivastava, Anil Kumar)[ 2 ] ; Taile, V Synthesis of 5-arylidine amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamides endowed with potent antioxidants and anticancer activity induces growth inhibition in HEK293, BT474 and NCI-H226 cells MEDICINAL CHEMISTRY RESEARCH Volume: 23 Issue: 6 Pages: 3049-3064, 2014 Stewart, DJ (Stewart, David J.)[ 1 ] ; Nunez, MI (Nunez, Maria I.)[ 2 ] ; Behrens, C (Behrens, Carmen)[ 2 ] ; Liu, DN (Liu, Diane)[ 3 ] ; Lin, YH (Lin, Yan Heather)[ 3 ] ; Lee, JJ (Lee, J. Jack)[ 3 ] ; Roth, J (Roth, Jack)[ 4 ] ; Heymach, J (Heymach, John)[ 5 ] ; Swisher, SG (Swisher, Stephen G.)[ 4 ] ; Hong, WK (Hong, Waun Ki)[ 5 ] ; Wistuba, II Membrane Carbonic Anhydrase IX Expression and Relapse Risk in Resected Stage I-II Non-Small-Cell Lung Cancer JOURNAL OF THORACIC ONCOLOGY Volume: 9 Issue: 5 Pages: 675-684, 2014 Ilardi, G (Ilardi, G.)[ 1 ] ; Zambrano, N (Zambrano, N.)[ 2 ] ; Merolla, F (Merolla, F.)[ 1 ] ; Siano, M (Siano, M.)[ 1 ] ; Varricchio, S (Varricchio, S.)[ 1 ] ; Vecchione, M (Vecchione, M.)[ 1 ] ; De Rosa, G (De Rosa, G.)[ 1 ] ; Mascolo, M (Mascolo, M.)[ 1 ] ; Staibano, S Histopathological Determinants of Tumor Resistance: A Special Look to the Immunohistochemical Expression of Carbonic Anhydrase IX in Human Cancers CURRENT MEDICINAL CHEMISTRY Volume: 21 Issue: 14 Pages: 1569-1582, 2014 Hu, XQ (Hu, Xuqi)[ 1 ] ; Zhou, YF (Zhou, Yifei)[ 1 ] ; Zheng, XH (Zheng, Xuhao)[ 1 ] ; Tian, NF (Tian, Naifeng)[ 1 ] ; Xu, C (Xu, Cong)[ 1 ] ; Wu, W (Wu, Wei)[ 1 ] ; Li, F (Li, Fan)[ 1 ] ; Zhu, SP (Zhu, Sipin)[ 1 ] ; Zheng, YJ (Zheng, Yijing)[ 1 ] ; Xue, EX (Xue, Enxing)[ 1 ] ; Yu, Y (Yu, Yang)[ 1 ] ; Zhang, XL (Zhang, Xiaolei)[ 1,2 ] ; Xu, HZ Differentiation of Menstrual Blood-Derived Stem Cells Toward Nucleus Pulposus-Like Cells in a Coculture System With Nucleus Pulposus Cells SPINE Volume: 39 Issue: 9 Pages: 754-760, 2014 Gallo, S (Gallo, S.)[ 1 ] ; Gatti, S (Gatti, S.)[ 1 ] ; Sala, V (Sala, V.)[ 1 ] ; Albano, R (Albano, R.)[ 2 ] ; Costelli, P (Costelli, P.)[ 3 ] ; Casanova, E (Casanova, E.)[ 2 ] ; Comoglio, PM (Comoglio, P. M.)[ 1,2 ] ; Crepaldi, T Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy CELL DEATH & DISEASE Volume: 5, Article Number: e1185, 2014 Ngo, TC (Ngo, Tin C.)[ 1 ] ; Wood, CG (Wood, Christopher G.)[ 1 ] ; Karam, JA Biomarkers of renal cell carcinoma UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS Volume: 32 Issue: 3 Pages: 243-251, 2014 Bloch, K (Bloch, Katarzyna)[ 1 ] ; Smith, H (Smith, Hannah)[ 2 ] ; Parsons, VV (Parsons, Victoria van Hamel)[ 2 ] ; Gavaghan, D (Gavaghan, David)[ 1 ] ; Kelly, C (Kelly, Catherine)[ 1,3 ] ; Fletcher, A (Fletcher, Alexander)[ 4 ] ; Maini, P (Maini, Philip)[ 4 ] ; Callaghan, R Metabolic Alterations During the Growth of Tumour Spheroids CELL BIOCHEMISTRY AND BIOPHYSICS Volume: 68 Issue: 3 Pages: 615-628, 2014 Pan, JH (Pan, Jinhe)[ 1 ] ; Lau, J (Lau, Joseph)[ 1 ] ; Mesak, F (Mesak, Felix)[ 1 ] ; Hundal, N (Hundal, Navjit)[ 1 ] ; Pourghiasian, M (Pourghiasian, Maral)[ 1 ] ; Liu, ZB (Liu, Zhibo)[ 2 ] ; Benard, F (Benard, Francois)[ 1 ] ; Dedhar, S (Dedhar, Shoukat)[ 3 ] ; Supuran, CT (Supuran, Claudiu T.)[ 4 ] ; Lin, KS Synthesis and evaluation of F-18-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Volume: 29 Issue: 2 Pages: 249-255, 2014 SitaRam (SitaRam)[ 1 ] ; Celik, G (Celik, Gulsah)[ 2 ] ; Khloya, P (Khloya, Poonam)[ 1 ] ; Vullo, D (Vullo, Daniela)[ 3 ] ; Supuran, CT (Supuran, Claudiu T.)[ 3,4 ] ; Sharma, PK Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII BIOORGANIC & MEDICINAL CHEMISTRY Volume: 22 Issue: 6 Pages: 1873-1882, 2014 Clatot, F (Clatot, Florian)[ 1,2 ] ; Gouerant, S (Gouerant, Sophie)[ 1,3 ] ; Mareschal, S (Mareschal, Sylvain)[ 2 ] ; Cornic, M (Cornic, Marie)[ 4 ] ; Berghian, A (Berghian, Anca)[ 4 ] ; Choussy, O (Choussy, Olivier)[ 5 ] ; El Ouakif, F (El Ouakif, Faissal)[ 6 ] ; Francois, A (Francois, Arnaud)[ 7 ] ; Benard, M (Benard, Magalie)[ 8 ] ; Ruminy, P The gene expression profile of inflammatory, hypoxic and metabolic genes predicts the metastatic spread of human head and neck squamous cell carcinoma ORAL ONCOLOGY Volume: 50 Issue: 3 Pages: 200-207, 2014 Matthews, TA (Matthews, Tori A.)[ 1 ] ; Abel, A (Abel, Allyssa)[ 2 ] ; Demme, C (Demme, Chris)[ 3 ] ; Sherman, T (Sherman, Teresa)[ 1 ] ; Pan, PW (Pan, Pei-wen)[ 5,6 ] ; Halterman, MW (Halterman, Marc W.)[ 4 ] ; Parkkila, S (Parkkila, Seppo)[ 5,6 ] ; Nehrke, K Expression of the CHOP-inducible carbonic anhydrase CAVI-b is required for BDNF-mediated protection from hypoxia BRAIN RESEARCH olume: 1543 Pages: 28-37, 2014 Wang, ZC (Wang, Zhong-Chang)[ 1 ] ; Duan, YT (Duan, Yong-Tao)[ 1 ] ; Qiu, HY (Qiu, Han-Yue)[ 1 ] ; Huang, WY (Huang, Wan-Yun)[ 1,2 ] ; Wang, PF (Wang, Peng-Fei)[ 1 ] ; Yan, XQ (Yan, Xiao-Qiang)[ 1 ] ; Zhang, SF (Zhang, Shu-Feng)[ 1,3 ] ; Zhu, HL Novel metronidazole-sulfonamide derivatives as potent and selective carbonic anhydrase inhibitors: design, synthesis and biology analysis RSC ADVANCES Volume: 4 Issue: 62 Pages: 33029-33038, 2014 Makino, K (Makino, Katsunari)[ 1 ] ; Jinnin, M (Jinnin, Masatoshi)[ 1 ] ; Makino, T (Makino, Takamitsu)[ 1 ] ; Kajihara, I (Kajihara, Ikko)[ 1 ] ; Fukushima, S (Fukushima, Satoshi)[ 1 ] ; Inoue, Y (Inoue, Yuji)[ 1 ] ; Ihn, H Serum levels of soluble carbonic anhydrase IX are decreased in patients with diffuse cutaneous systemic sclerosis compared to those with limited cutaneous systemic sclerosis BIOSCIENCE TRENDS Volume: 8 Issue: 3 Pages: 144-148, 2014 Wong, BCK (Wong, Blenda Chi Kwan)[ 1 ] ; Zhang, HQ (Zhang, Hongqi)[ 1 ] ; Qin, L (Qin, Ling)[ 2 ] ; Chen, HB (Chen, Hubiao)[ 1 ] ; Fang, C (Fang, Chen)[ 1 ] ; Lu, AP (Lu, Aiping)[ 1 ] ; Yang, ZJ Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro DRUG DESIGN DEVELOPMENT AND THERAPY Volume: 8 Pages: 993-1001, 2014 Mujcic, H (Mujcic, H.)[ 1,2,3 ] ; Hill, RP (Hill, R. P.)[ 1,2,5,4 ] ; Koritzinsky, M (Koritzinsky, M.)[ 1,2,3,4,6 ] ; Wouters, BG Hypoxia Signaling and the Metastatic Phenotype CURRENT MOLECULAR MEDICINE Volume: 14 Issue: 5 Pages: 565-579, 2014 Frost, Susan C. hysiological Functions of the Alpha Class of Carbonic Anhydrases Edited by: Frost, SC; McKenna, R CARBONIC ANHYDRASE: MECHANISM, REGULATION, LINKS TO DISEASE, AND INDUSTRIAL APPLICATIONS Book Series: Subcellular Biochemistry Volume: 75 Pages: 9-30 Published: 2014 Tafreshi, NK (Tafreshi, Narges K.)[ 1 ] ; Lloyd, MC (Lloyd, Mark C.)[ 2 ] ; Bui, MM (Bui, Marilyn M.)[ 2,3 ] ; Gillies, RJ (Gillies, Robert J.)[ 1 ] ; Morse, DL Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases Edited by:Frost, SC; McKenna, R CARBONIC ANHYDRASE: MECHANISM, REGULATION, LINKS TO DISEASE, AND INDUSTRIAL APPLICATIONS Book Series: Subcellular Biochemistry Volume: 75 Pages: 221-254, 2014 Zolnowska, B (Zolnowska, Beata)[ 1 ] ; Slawinski, J (Slawinski, Jaroslaw)[ 1 ] ; Pogorzelska, A (Pogorzelska, Aneta)[ 1 ] ; Chojnacki, J (Chojnacki, Jaroslaw)[ 2 ] ; Vullo, D (Vullo, Daniela)[ 3 ] ; Supuran, CT Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N '-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 71 Pages: 135-147, 2014 Akurathi, V (Akurathi, Vamsidhar)[ 1 ] ; Dubois, L (Dubois, Ludwig)[ 2 ] ; Celen, S (Celen, Sofie)[ 1 ] ; Lieuwes, NG (Lieuwes, Natasja G.)[ 2 ] ; Chitneni, SK (Chitneni, Satish K.)[ 1 ] ; Cleynhens, BJ (Cleynhens, Bernard J.)[ 1 ] ; Innocenti, A (Innocenti, Alessio)[ 3 ] ; Supuran, CT (Supuran, Claudiu T.)[ 3 ] ; Verbruggen, AM (Verbruggen, Alfons M.)[ 1 ] ; Lambin, P (Lambin, Philippe)[ 2 ] ; Bormans, GM Development and biological evaluation of Tc-99m-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 71 Pages: 374-384, 2014 Furjelova, M (Furjelova, Martina)[ 1 ] ; Kovalska, M (Kovalska, Maria)[ 1 ] ; Jurkova, K (Jurkova, Katarina)[ 1,3 ] ; Horacek, J (Horacek, Jaroslav)[ 2 ] ; Carbolova, T (Carbolova, Tereza)[ 4 ] ; Adamkov, M Carbonic anhydrase IX: A promising diagnostic and prognostic biomarker in breast carcinoma ACTA HISTOCHEMICA Volume: 116 Issue: 1 Pages: 89-93, 2014 Capkova, L.; Koubkova, L.; Kodet, R. Expression of carbonic anhydrase IX (CAIX) in malignant mesothelioma. An immunohistochemical and immunocytochemical study NEOPLASMA Volume: 61 Issue: 2 Pages: 161-169 Published: 2014 Helena Ng, H.L.a , Lu, A.ab , Lin, G.c , Qin, L.d , Yang, Z. The potential of liposomes with carbonic anhydrase IX to deliver anticancer ingredients to cancer cells in Vivo Volume 16, Issue 1, 24 December 2014, Pages 230-255 Garcia-Roig, M.a, Ortiz, N.a, Lokeshwar, V. Molecular marker for predicting treatment response in advanced renal cell carcinoma: Does the promise fulfill clinical need? Current Urology Reports Volume 15, Issue 1, January 2014, Article number 375 Aly, R.a , Elghannam, D.M.a, Yousef, A.B. Relationships between TIMP-1, CAIX, and clinical outcomes in Egyptian breast cancer Comparative Clinical Pathology Relationships between TIMP-1, CAIX, and clinical outcomes in Egyptian breast cance Comparative Clinical Pathology Volume 23, Issue 4, July 2014, Pages 907-916 Pan, J.a, Lau, J.a, Mesak, F.a, Hundal, N.a, Pourghiasian, M.a, Liu, Z.b, Bénard, F.a, Dedhar, S.c, Supuran, C.T.d, Lin, K.-S. Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography Journal of Enzyme Inhibition and Medicinal Chemistry Volume 29, Issue 2, April 2014, Pages 249-255 Takahashi, H (Takahashi, Hidekazu)[ 1,2 ] ; Suzuki, Y (Suzuki, Yozo)[ 1,3 ] ; Nishimura, J (Nishimura, Junichi)[ 1 ] ; Haraguchi, N (Haraguchi, Naotsugu)[ 1,4 ] ; Ohtsuka, M (Ohtsuka, Masahisa)[ 1,5 ] ; Miyazaki, S (Miyazaki, Susumu)[ 6 ] ; Uemura, M (Uemura, Mamoru)[ 1 ] ; Hata, T (Hata, Taishi)[ 1 ] ; Takemasa, I (Takemasa, Ichiro)[ 1 ] ; Mizushima, T (Mizushima, Tsunekazu)[ 1 ] ; Yamamoto, H (Yamamoto, Hirofumi)[ 1 ] ; Doki, Y (Doki, Yuichiro)[ 1 ] ; Mori, M Characteristics of carbonic anhydrase 9 expressing cells in human intestinal crypt base INTERNATIONAL JOURNAL OF ONCOLOGY Volume: 48 Issue: 1 Pages: 115-122, 2015 Guan, SS (Guan, Siao-Syun)[ 1,2 ] ; Cheng, CC (Cheng, Chun-Chia)[ 1,3 ] ; Ho, AS (Ho, Ai-Sheng)[ 4 ] ; Wang, CC (Wang, Chia-Chi)[ 5,6 ] ; Luo, TY (Luo, Tsai-Yueh)[ 1 ] ; Liao, TZ (Liao, Tse-Zung)[ 1 ] ; Chang, JS (Chang, Jungshan)[ 3 ] ; Wu, CT (Wu, Cheng-Tien)[ 2 ] ; Liu, SH Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo ONCOTARGET Volume: 6 Issue: 34 Pages: 36139-36155, 2015 Pinheiro, C (Pinheiro, Celine)[ 1,2,3,4 ] ; Garcia, EA (Garcia, Eduardo A.)[ 3,4 ] ; Morais-Santos, F (Morais-Santos, Filipa)[ 1,2 ] ; Moreira, MAR (Moreira, Marise A. 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L.)[ 2,3 ] ; Reed, MJ (Reed, Michael J.)[ 1 ] ; Purohit, A (Purohit, Atul)[ 1 ] ; Foster, PA The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression ANTICANCER RESEARCH Volume: 35 Issue: 10 Pages: 5249-5261, 2015 Peeters, SGJA (Peeters, Sarah G. J. 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rok vydania rok metriky IF IF Q (best) SJR SJR Q (best) 2000 1999 8.614
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