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Plasma concentration, tissue distribution and excretion of the prospective cardioprotective agent cis-(-)-2,3,4,4a,5,9b-hexahydro-2,8-dimethyl-1h-pyrido-[4,3-b]indole dihydrochloride in rats
Title Plasma concentration, tissue distribution and excretion of the prospective cardioprotective agent cis-(-)-2,3,4,4a,5,9b-hexahydro-2,8-dimethyl-1h-pyrido-[4,3-b]indole dihydrochloride in rats Author Kállay Zoltán SAVEXFATO - Ústav experimentálnej farmakológie a toxikológie SAV SCOPUS Co-authors Bittererová Juliana Faberová Viera Bezek Štefan 1948- SAVEXFATO - Ústav experimentálnej farmakológie a toxikológie SAV SCOPUS Trnovec Tomáš SAVEXFATO - Ústav experimentálnej farmakológie a toxikológie SAV SCOPUS Co-authors Brejcha A. Source document Arzneimittel-Forschung/Drug Research. Vol. 40(II), no. 9 (1990), p. 974-979, Special section: biotechnology in drug research Language eng - English Country DE - Germany Document kind rozpis článkov z periodík (rbx) Citations JURANEK, I. - HORAKOVA, L. - RACKOVA, L. - STEFEK, M. Antioxidants in Treating Pathologies Involving Oxidative Damage: An Update on Medicinal Chemistry and Biological Activity of Stobadine and Related Pyridoindoles. In CURRENT MEDICINAL CHEMISTRY. ISSN 0929-8673, 2010, vol. 17, no. 6, p. 552-570. SOTNIKOVA, R. - SKALSKA, S. - OKRUHLICOVA, L. - NAVAROVA, J. - KYSELOVA, Z. - ZUROVA, J. - STEFEK, M. - HOZOVA, R. - NOSALOVA, V. Changes in the function and ultrastructure of vessels in the rat model of multiple low dose streptozotocin-induced diabetes. In GENERAL PHYSIOLOGY AND BIOPHYSICS. ISSN 0231-5882, 2006, vol. 25, no. 3, p. 289-302. KYSELOVA, Z. - GAJDOSIK, A. - GAJDOSIKOVA, A. - ULICNA, O. - MIHALOVA, D. - KARASU, C. - STEFEK, M. Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT. In MOLECULAR VISION. ISSN 1090-0535, 2005, vol. 11, no. 6, p. 56-65. NAVAROVA, J. - UJHAZY, E. - LISKA, J. - DUBOVICKY, M. Determination of selective biochemical variables in pregnant and lactating mice after stobadine administration. In METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY. ISSN 0379-0355, 2003, vol. 25, no. 9, p. 717-721. SOTNIKOVA, R. - STEFEK, L. - OKRUHLICOVA, L. - NAVAROVA, J. - BAUER, V. - GAJDOSIK, A. - GAJDOSIKOVA, A. Dietary supplementation of the pyridoindole antioxidant stobadine reduces vascular impairment in streptozotocin-diabetic rats. In METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY. ISSN 0379-0355, 2001, vol. 23, no. 3, p. 121-129. STEFEK, M. - SOTNIKOVA, R. - OKRUHLICOVA, L. - VOLKOVOVA, K. - KUCHARSKA, J. - GAJDOSIK, A. - GAJDOSIKOVA, A. - MIHALOVA, D. - HOZOVA, R. - TRIBULOVA, N. - GVOZDJAKOVA, A. Effect of dietary supplementation with the pyridoindole antioxidant stobadine on antioxidant state and ultrastructure of diabetic rat myocardium. In ACTA DIABETOLOGICA. ISSN 0940-5429, 2000, vol. 37, no. 3, p. 111-117. BAUEROVA, K. Overview of stobadine bioanalysis: evaluation and application in pharmacokinetics. In EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. ISSN 0378-7966, 1999, vol. 24, no. 3, p. 237-242. STOLC, S. Indole derivatives as neuroprotectants. In LIFE SCIENCES. ISSN 0024-3205, 1999, vol. 65, no. 18-19, p. 1943-1950. HORAKOVA, L. - STOLC, S. Antioxidant and pharmacodynamic effects of pyridoindole stobadine. In GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM. ISSN 0306-3623, 1998, vol. 30, no. 5, p. 627-638. STOLC, S. - VLKOLINSKY, R. - PAVLASEK, J. Neuroprotection by the pyridoindole stobadine: A minireview. In BRAIN RESEARCH BULLETIN. ISSN 0361-9230, 1997, vol. 42, no. 5, p. 335-340. STEFEK, M. - DROZDIKOVA, I. - VAJDOVA, K. The pyridoindole antioxidant stobadine inhibited glycation-induced absorbance and fluorescence changes in albumin. In ACTA DIABETOLOGICA. ISSN 0940-5429, 1996, vol. 33, no. 1, p. 35-40. PAVLASEK, J. - HABURCAK, M. - MASANOVA, C. - STOLC, S. Transport of an antihypoxic drug stobadine across the blood-brain barrier in rat striatum and its influence on catecholamine-oxidative current: A voltammetric study under normal and anoxic/ischaemic conditions. In PHYSIOLOGICAL RESEARCH. ISSN 0862-8408, 1996, vol. 45, no. 3, p. 193-204 BENES, L. - PRONAYOVA, N. Free-radical scavenger prodrugs - potentially potent brain penetrating agents. In PHARMAZIE. ISSN 0031-7144, 1994, vol. 49, no.1, p. 69-70. UJHAZY, E. - BALONOVA, T. - VARGOVA, T. - JANSAK, J. - DERKOVA, L. Teratological study of stobadin after single and repeated administration in rats. In TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS. ISSN 0270-3211, 1992, vol. 12, no. 5, p. 211-221. HORAKOVA, L. - ONDREJICKOVA, O. - URAZ, V. - LUKOVIC, L. - JURANEK, I. Short cerebral-ischemia and subsequent reperfusion and treatment with stobadine. In EXPERIENTIA. ISSN 0014-4754, 1992, vol. 48, no. 9, p. 872-874. BALONOVA, T. - ZELJENKOVA, D. - DURISOVA, M. - NOSAL, R. - JAKUBOVSKY, J. - LISKA, J. - STOLC, S. Reproductive toxicity studies with cis-(-)-2,3,4,4A,5,9b-hexahydro-2,8-dimethyl-1h-pyrido-[4,3-b]indole dipalmitate in rats. In ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH. ISSN 0004-4172, 1991, vol. 41-1, no. 1, p. 1-5. PONIST, S. - MIHALOVA, D. - JANCINOVA, V. - SNIRC, V. - ONDREJICKOVA, O. - MASCIA, C. - POLI, G. - STANCIKOVA, M. - NOSAL, R. - BAUEROVA, K. Reduction of oxidative stress in adjuvant arthritis. Comparison of efficacy of two pyridoindoles: stobadine dipalmitate and SMe1.2HCl. In ACTA BIOCHIMICA POLONICA. ISSN 0001-527X, 2010, vol. 57, no. 2, p. 223-228. STEFEK, M. - GAJDOSIK, A. - GAJDOSIKOVA, A. - JUSKOVA, M. - KYSELOVA, Z. - MAJEKOVA, M. - RACKOVA, L. - SNIRC, V. - DEMOPOULOS, V. - KARASU, C. Stobadine and related pyridoindoles as antioxidants and aldose reductase inhibitors in prevention of diabetic complications. Chapt. 14. In Stefek, M. ed. Advances in molecular mechanisms and pharmacology of diabetic complications. Kerala: Transworld research network 2010. ISBN 978-81-7895-499-8, P. 285-307 SAKUL, A. - CUMAOGLU, A. - AYDIN, E. - ARI, N. - DILSIZ, N. - KARASU, C. Age- and diabetes-induced regulation of oxidative protein modification in rat brain and peripheral tissues: Consequences of treatment with antioxidant pyridoindole. In EXPERIMENTAL GERONTOLOGY. ISSN 0531-5565, 2013, vol. 48, no. 5, p. 476-484. Category ADCA - Scientific papers in foreign journals registered in Current Contents Connect with IF (impacted) Category of document (from 2022) V3 - Vedecký výstup publikačnej činnosti z časopisu Type of document článok Year 1990 
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