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7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies
Title 7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies Author Špilovská Katarína Co-authors Korábečný Jan Král Jan Horová Anna Musílek Kamil Soukup Ondrej Drtinová Lucie Gažová Zuzana 1961- SAVEXFYZ - Ústav experimentálnej fyziky SAV SCOPUS RID ORCID Šipošová Katarína 1982 SAVEXFYZ - Ústav experimentálnej fyziky SAV ORCID Kuča Kamil Source document Molecules. Vol. 18, no. 2 (2013), p. 2397-2418 Language eng - English Document kind rozpis článkov z periodík (rbx) Citations VARADARAJU, Kavitha Raj - KUMAR, Jajur Ramanna - MALLESHA, Lingappa - MURULI, Archana - MOHANA, Kikkeri Narasimha Shetty - MUKUNDA, Chethan Kumar - SHARANAIAH, Umesha. Virtual screening and biological evaluation of piperazine derivatives as human acetylcholinesterase inhibitors. In International Journal of Alzheimer's Disease, 2013-12-04, 2013. FROESTL, Wolfgang - MUHS, Andreas - PFEIFER, Andrea. Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes. Update 2014. In JOURNAL OF ALZHEIMERS DISEASE. ISSN 1387-2877, 2014, vol. 42, no. 1, pp. 1-68. CACABELOS, Ramon - CACABELOS, Pablo - TORRELLAS, Clara - TELLADO, Ivan - CARRIL, Juan C. Pharmacogenomics of Alzheimer's Disease: Novel Therapeutic Strategies for Drug Development. In PHARMACOGENOMICS IN DRUG DISCOVERY AND DEVELOPMENT, 2ND EDITION. ISSN 1064-3745, 2014, vol. 1175, pp. 323-556.. IQBAL, Jamshed - ZAIB, Sumera - SAEED, Aamer - MUDDASSAR, Muhammad. Biological Evaluation of Halogenated Thioureas as Cholinesterases Inhibitors Against Alzheimer's Disease & Molecular Modeling Studies. In LETTERS IN DRUG DESIGN & DISCOVERY. ISSN 1570-1808, 2015, vol. 12, no. 6, pp. 488-494. AL-ABDULLAH, Ebtehal S. - AL-TUWAIJRI, Hanaa M. - HASSAN, Hanan M. - AL-ALSHAIKH, Monirah A. - HABIB, Elsayed E. - EL-EMAM, Ali A. Synthesis, Antimicrobial and Hypoglycemic Activities of Novel N-(1-Adamantyl)carbothioamide Derivatives. In MOLECULES. ISSN 1420-3049, 2015, vol. 20, no. 5, pp. 8125-8143. NUNES, B. - ANTUNES, S. C. - GOMES, R. - CAMPOS, J. C. - BRAGA, M. R. - RAMOS, A. S. - CORREIA, A. T. Acute Effects of Tetracycline Exposure in the Freshwater Fish Gambusia holbrooki: Antioxidant Effects, Neurotoxicity and Histological Alterations. In ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY. ISSN 0090-4341, 2015, vol. 68, no. 2, pp. 371-381. CACABELOS, Ramon - TORRELLAS, Clara - CARRERA, Ivan - CACABELOS, Pablo - CORZO, Lola - FERNANDEZ-NOVOA, Lucia - TELLADO, Ivan - CARLOS CARRIL, Juan - ALIEV, Gjumrakch. Novel Therapeutic Strategies for Dementia. In CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS. ISSN 1871-5273, 2016, vol. 15, no. 2, pp. 141-241. SCHMIDT, Ines - PRADEL, Gabriele - SOLOGUB, Ludmilla - GOLZMANN, Alexandra - NGWA, Che J. - KUCHARSKI, Anna - SCHIRMEISTER, Tanja - HOLZGRABE, Ulrike. Bistacrine derivatives as new potent antimalarials. In BIOORGANIC & MEDICINAL CHEMISTRY. ISSN 0968-0896, 2016, vol. 24, no. 16, pp. 3636-3642. MARTORANA, Annamaria - GIACALONE, Valentina - BONSIGNORE, Riccardo - PACE, Andrea - GENTILE, Carla - PIBIRI, Ivana - BUSCEMI, Silvestre - LAURIA, Antonino - PICCIONELLO, Antonio Palumbo. Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease. In CURRENT PHARMACEUTICAL DESIGN. ISSN 1381-6128, 2016, vol. 22, no. 26, pp. 3971-3995. MILELLI, Andrea - DE SIMONE, Angela - TICCHI, Nicole - CHEN, Huan H. - BETARI, Nibal - ANDRISANO, Vincenza - TUMIATTI, Vincenzo. Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development. In CURRENT MEDICINAL CHEMISTRY. ISSN 0929-8673, 2017, vol. 24, no. 32, pp. 3522-3546. LIN, Hongzhi - LI, Qi - GU, Kai - ZHU, Jie - JIANG, Xueyang - CHEN, Yao - SUN, Haopeng. Therapeutic Agents in Alzheimer's Disease Through a Multi-target-directed Ligands Strategy: Recent Progress Based on Tacrine Core. In CURRENT TOPICS IN MEDICINAL CHEMISTRY. ISSN 1568-0266, 2017, vol. 17, no. 27, pp. 3000-3016. DAS, Sucharita - BASU, Soumalee. Multi-targeting Strategies for Alzheimer's Disease Therapeutics: Pros and Cons. In CURRENT TOPICS IN MEDICINAL CHEMISTRY. ISSN 1568-0266, 2017, vol. 17, no. 27, pp. 3017-3061. LI, Qi - YANG, Hongyu - CHEN, Yao - SUN, Haopeng. Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease. In EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. ISSN 0223-5234, 2017, vol. 132, pp. 294-309. FEDOTOVA, Alena I. - KOMAROVA, Tatiana A. - ROMANOV, Alexey R. - USHAKOV, Igor A. - LEGROS, Julien - MADDALUNO, Jacques - RULEV, Alexander Yu. Adamantyl aziridines via aza-Michael initiated ring closure (aza-MIRC) reaction. In TETRAHEDRON. ISSN 0040-4020, 2017, vol. 73, no. 8, pp. 1120-1126. ISMAILI, Lhassane - REFOUVELET, Bernard - BENCHEKROUN, Mohamed - BROGI, Simone - BRINDISI, Margherita - GEMMA, Sandra - CAMPIANI, Giuseppe - FILIPIC, Slavica - AGBABA, Danica - ESTEBAN, Gerard - UNZETA, Mercedes - NIKOLIC, Katarina - BUTINI, Stefania - MARCO-CONTELLES, Jose. Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease. In PROGRESS IN NEUROBIOLOGY. ISSN 0301-0082, 2017, vol. 151, pp. 4-34. SCOTTI, Luciana - MENDONA JUNIOR, Francisco J. B. - ISHIKI, Hamilton M. - RIBEIRO, Frederico F. - SINGLA, Rajeev K. - BARBOSA FILHO, Jose M. - DA SILVA, Marcelo S. - SCOTTI, Marcus T. Docking Studies for Multi-Target Drugs. In CURRENT DRUG TARGETS. ISSN 1389-4501, 2017, vol. 18, no. 5, pp. 592-604. KUZNETSOV, A. I. - SENAN, I. M. - ALASADI, R. T. - ABDULNABI, N. M. - SEROVA, T. M. Synthesis of N,N-di(1-adamantyl)bispidin-9-ones. In RUSSIAN CHEMICAL BULLETIN. ISSN 1066-5285, 2018, vol. 67, no. 6, pp. 1110-1113. BURMISTROV, Vladimir - MORISSEAU, Christophe - PITUSHKIN, Dmitry - KARLOV, Dmitry - FAYZULLIN, Robert R. - BUTOV, Gennady M. - HAMMOCK, Bruce D. Adamantyl thioureas as soluble epoxide hydrolase inhibitors. In BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. ISSN 0960-894X, 2018, vol. 28, no. 13, pp. 2302-2313. SIMUNKOVA, Miriama - ALWASEL, Saleh H. - ALHAZZA, Ibrahim M. - JOMOVA, Klaudia - KOLLAR, Vojtech - RUSKO, Miroslav - VALKO, Marian. Management of oxidative stress and other pathologies in Alzheimer's disease. In ARCHIVES OF TOXICOLOGY. ISSN 0340-5761, 2019, vol. 93, no. 9, pp. 2491-2513. MESITI, Francesco - CHAVARRIA, Daniel - GASPAR, Alexandra - ALCARO, Stefano - BORGES, Fernanda. The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease. In EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. ISSN 0223-5234, 2019, vol. 181. RODRIGUEZ-SOACHA, Diego Alejandro - SCHEINER, Matthias - DECKER, Michael. Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. In EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. ISSN 0223-5234, 2019, vol. 180, pp. 690-706. JAVIER PEREZ-AREALES, F. - TURCU, Andreea L. - BARNIOL-XICOTA, Marta - PONT, Caterina - PIVETTA, Deborah - ESPARGARO, Alba - BARTOLINI, Manuela - DE SIMONE, Angela - ANDRISANO, Vincenza - PEREZ, Beier' - SABATE, Raimon - SUREDA, Francesc X. - VAZQUEZ, Santiago - MUNOZ-TORRERO, Diego. A novel class of multitarget anti-Alzheimer benzohomoadamantane- chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors. In EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. ISSN 0223-5234, 2019, vol. 180, pp. 613-626. GIREK, Malgorzata - SZYMANSKI, Pawel. Tacrine hybrids as multi-target-directed ligands in Alzheimer's disease: influence of chemical structures on biological activities. In CHEMICAL PAPERS. ISSN 2585-7290, 2019, vol. 73, no. 2, pp. 269-289. 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Memantine Derivatives as Multitarget Agents in Alzheimer's Disease. In MOLECULES, 2020, vol. 25, no. 17. DYACHENKO, V. D. - SUKACH, S. M. - MORKOVNIK, A. S. 2-Acylcycloalkanones in Organic Synthesis. In RUSSIAN JOURNAL OF ORGANIC CHEMISTRY. ISSN 1070-4280, 2020, vol. 56, no. 6, pp. 949-973. MUNAWAR, Rabya - MUSHTAQ, Nousheen - AHMAD, Ahsaan - SAEED, Syed Muhammad Ghufran - USMANI, Saman - AKHTAR, Shamim - SAIFY, Z. S. - ARIF, Muhammad - AKRAM, Arifa. Molecular docking, synthesis and biological evaluation of phenacyl derivatives of 9-aminoacridine as anti-Alzheimer's agent. In PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES. ISSN 1011-601X, 2020, vol. 33, no. 2, pp. 659-668. BAGRI, Kiran - KUMAR, Ashwani - MANISHA - KUMAR, Parvin. Computational Studies on Acetylcholinesterase Inhibitors: From Biochemistry to Chemistry. In MINI-REVIEWS IN MEDICINAL CHEMISTRY. ISSN 1389-5575, 2020, vol. 20, no. 14, pp. 1403-1435. MANZOOR, Shoaib - GABR, Moustafa T. - RASOOL, Bisma - PAL, Kavita - HODA, Nasimul. Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease. In BIOORGANIC CHEMISTRY, 2021, vol. 116, no., pp. ISSN 0045-2068. Dostupné na: https://doi.org/10.1016/j.bioorg.2021.105354. KLIMOCHKIN, Yu N. - IVLEVA, E. A. - SHIRYAEV, V. A. Reactions of Cage Substrates with Sulfur Nucleophiles. In RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2021, vol. 57, no. 3, pp. 355-363. ISSN 1070-4280. Dostupné na: https://doi.org/10.1134/S1070428021030052. GOULART, Paula do N. - CARUSO, Lucas - NADUR, Nathalia F. - FRANCO, Daiana P. - KUMMERLE, Arthur E. - LACERDA, Renata B. Butyrylcholinesterase BuChE: A Potential Target for Development of Drugs for Alzheimer's Disease Treatment. In REVISTA VIRTUAL DE QUIMICA, 2021, vol. 13, no. 1, pp. 90-126. ISSN 1984-6835. Dostupné na: https://doi.org/10.21577/1984-6835.20200133. WANG, Zhiguo - YANG, Baofeng. Polypharmacology: Principles and methodologies. In Polypharmacology: Principles and Methodologies, 2022-08-01, pp. 1-856. Dostupné na: https://doi.org/10.1007/978-3-031-04998-9. Category ADCA - Scientific papers in foreign journals registered in Current Contents Connect with IF (impacted) Category of document (from 2022) V3 - Vedecký výstup publikačnej činnosti z časopisu Type of document článok Year 2013 Registered in WOS Registered in SCOPUS Registered in CCC DOI 10.3390/molecules18022397 
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rok CC IF IF Q (best) JCR Av Jour IF Perc SJR SJR Q (best) CiteScore A rok vydania rok metriky IF IF Q (best) SJR SJR Q (best) 2013 2012 2.428 Q2 0.792 Q1
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