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Bexarotene Does Not Clear Amyloid Beta Plaques but Delays Fibril Growth: Molecular Mechanisms
Title Bexarotene Does Not Clear Amyloid Beta Plaques but Delays Fibril Growth: Molecular Mechanisms Author Huy Pham Dinh Quoc Co-authors Nguyen Duc Thai 1970 Bednáriková Zuzana 1988 SAVEXFYZ - Ústav experimentálnej fyziky SAV SCOPUS ORCID Phuc Le Huu Linh Huynh Quang Gažová Zuzana 1961- SAVEXFYZ - Ústav experimentálnej fyziky SAV SCOPUS RID ORCID Suan Li Mai Source document ACS Chemical Neuroscience. Vol. 8, no. 9 (2017), p. 1960-1969 Language eng - English Country US - United States of America Document kind rozpis článkov z periodík (rbx) Citations LINH TRAN. Understanding the Binding Mechanism of Amyloid-beta Inhibitors from Molecular Simulations. In CURRENT PHARMACEUTICAL DESIGN. ISSN 1381-6128, 2018, vol. 24, no. 28, pp. 3341-3346. LINH TRAN - KAFFY, Julia - ONGERI, Sandrine - TAP HA-DUONG. Binding Modes of a Glycopeptidomimetic Molecule on A beta Protofibrils: Implication for Its Inhibition Mechanism. In ACS CHEMICAL NEUROSCIENCE. ISSN 1948-7193, 2018, vol. 9, no. 11, pp. 2859-+. KAMP, Frits - SCHEIDT, Holger A. - WINKLER, Edith - BASSET, Gabriele - HEINEL, Hannes - HUTCHISON, James M. - LAPOINTE, Loren M. - SANDERS, Charles R. - STEINER, Harald - HUSTER, Daniel. Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its alpha-Helical Conformation, and Inhibits gamma-Secretase Nonselectively in Liposomes. In ACS CHEMICAL NEUROSCIENCE. ISSN 1948-7193, 2018, vol. 9, no. 7, pp. 1702-1713. FITZ, Nicholas F. - NAM, Kyong Nyon - KOLDAMOVA, Radosveta - LEFTEROV, Iliya. Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease. In BRITISH JOURNAL OF PHARMACOLOGY. ISSN 0007-1188, 2019, vol. 176, no. 18, pp. 3599-3610. XING, Xiaofeng - LIU, Chengqiang - ALI, Aqsa - KANG, Baotao - LI, Ping - AI, Hongqi. Novel Disassembly Mechanisms of Sigmoid A beta(42) Protofibrils by Introduced Neutral and Charged Drug Molecules. In ACS CHEMICAL NEUROSCIENCE. ISSN 1948-7193, 2020, vol. 11, no. 1, pp. 45-56. DE SIMONE, Angela - NALDI, Marina - TEDESCO, Daniele - BARTOLINI, Manuela - DAVANI, Lara - ANDRISANO, Vincenza. Advanced analytical methodologies in Alzheimer's disease drug discovery. In JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. ISSN 0731-7085, 2020, vol. 178, no., pp. BOOPATHI, Subramanian - POMA, Adolfo B. - GARDUNO-JUAREZ, Ramon. An Overview of Several Inhibitors for Alzheimer's Disease: Characterization and Failure. In INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, vol. 22, no. 19, pp. Dostupné na: https://doi.org/10.3390/ijms221910798. KAUR, Rajdeep - SAINI, Rajneet Kaur - SINGH, Pritpal - GOYAL, Bhupesh. Unveiling the inhibitory mechanism of peptidomimetic inhibitor against A beta(42) aggregation and protofibril disaggregation by molecular dynamics. In JOURNAL OF MOLECULAR LIQUIDS. ISSN 0167-7322, 2021, vol. 335, no., pp. Dostupné na: https://doi.org/10.1016/j.molliq.2021.116474. XU, Weiyuan - GAO, Chao - SUN, Xinyang - TAI, William Chi-Shing - LUNG, Hong Lok - LAW, Ga-Lai. Design, synthesis and comparison of water-soluble phthalocyanine/porphyrin analogues and their inhibition effects on A beta(42) fibrillization. In INORGANIC CHEMISTRY FRONTIERS. ISSN 2052-1553, 2021, vol. 8, no. 14, pp. 3501-3513. Dostupné na: https://doi.org/10.1039/d1qi00237f. GRAYSON, James D. - BAUMGARTNER, Matthew P. - SOUZA, Cleide Dos Santos - DAWES, Samuel J. - EL IDRISSI, Imane Ghafir - LOUTH, Jennifer C. - STIMPSON, Sasha - MEAD, Emma - DUNBAR, Charlotte - WOLAK, Joanna - SHARMAN, Gary - EVANS, David - ZHURAVLEVA, Anastasia - ROLDAN, Margarita Segovia - COLABUFO, Nicola Antonio - NING, Ke - GARWOOD, Claire - THOMAS, James A. - PARTRIDGE, Benjamin M. - DE LEON, Antonio de la Vega - GILLET, Valerie J. - RAUTER, Amelia P. - CHEN, Beining. Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting A beta o-PrP(C) binding and downstream pathways. In CHEMICAL SCIENCE. ISSN 2041-6520, 2021, vol. 12, no. 10, pp. 3768-3785. Dostupné na: https://doi.org/10.1039/d0sc04769d. MEI, Jinfei - YANG, Huijuan - SUN, Bo - LIU, Chengqiang - AI, Hongqi. Small-Molecule Targeted A beta(42) Aggregate Degradation: Negatively Charged Small Molecules Are More Promising than the Neutral Ones. In ACS CHEMICAL NEUROSCIENCE. ISSN 1948-7193, 2021, vol. 12, no. 7, pp. 1197-1209. Dostupné na: https://doi.org/10.1021/acschemneuro.1c00047. WANG, Ke - NA, Liu - DUAN, Mojie. The Pathogenesis Mechanism, Structure Properties, Potential Drugs and Therapeutic Nanoparticles against the Small oligomers of Amyloid-beta. In CURRENT TOPICS IN MEDICINAL CHEMISTRY. ISSN 1568-0266, 2021, vol. 21, no. 2, pp. 151-167. Dostupné na: https://doi.org/10.2174/1568026620666200916123000. HACIOGLU, Ceyhan - KAR, Fatih - KANBAK, Gungor. Ex Vivo Investigation of Bexarotene and Nicotinamide Function as a Protective Agent on Rat Synaptosomes Treated with A beta(1-42). In NEUROCHEMICAL RESEARCH. ISSN 0364-3190, 2021, vol. 46, no. 4, pp. 804-818. Dostupné na: https://doi.org/10.1007/s11064-020-03216-7. MOGHADDAM, S.M.F. - XU, Y.C. - SHERMAN, M.B. - ORLOVA, E.V. - KARKI, P. - ORMAN, M.A. - VEKILOV, P.G. Suppression of amyloid-? fibril growth by drug-engineered polymorph transformation. In JOURNAL OF BIOLOGICAL CHEMISTRY. DEC 2022, vol. 298, no. 12. SMERALDA, W. - SINCE, M. - CORVAISIER, S. - FAYOLLE, D. - CARDIN, J. - DUPREY, S. - JOURDAN, J.P. - CULLIN, C. - MALZERT-FREON, A. A Biomimetic Multiparametric Assay to Characterise Anti-Amyloid Drugs. In INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. ISSN 1661-6596, DEC 2023, vol. 24, no. 23. Dostupné na: https://doi.org/10.3390/ijms242316982. SOFINSKA, K. - BATYS, P. - CERNESCU, A. - GHOSH, D. - SKIRLINSKA-NOSEK, K. - BARBASZ, J. - SEWERYN, S. - WILKOSZ, N. - RIEK, R. - SZYMONSKI, M. - LIPIEC, E. Nanoscale insights into the local structural rearrangements of amyloid-β induced by bexarotene. In NANOSCALE. ISSN 2040-3364, SEP 14 2023, vol. 15, no. 35, p. 14606-14614. Dostupné na: https://doi.org/10.1039/d3nr01608k. LIU, Y.T. - WANG, P.W. - JIN, G.F. - SHI, P.J. - ZHAO, Y.H. - GUO, J.Y. - YIN, Y.L. - SHAO, Q.H. - LI, P. - YANG, P.F. The novel function of bexarotene for neurological diseases. In AGEING RESEARCH REVIEWS. ISSN 1568-1637, SEP 2023, vol. 90. Dostupné na: https://doi.org/10.1016/j.arr.2023.102021. GUPTA, S. - DASMAHAPATRA, A.K. Enhanced stability of a disaggregated Aβ fibril on removal of ligand inhibits refibrillation: An all atom Molecular Dynamics simulation study. In INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. ISSN 0141-8130, JUN 15 2023, vol. 240. Dostupné na: https://doi.org/10.1016/j.ijbiomac.2023.124481. Category ADMA - Scientific papers in foreign impacted journals registered in Web of Sciences or Scopus Category of document (from 2022) V3 - Vedecký výstup publikačnej činnosti z časopisu Type of document článok Year 2017 Registered in WOS Registered in SCOPUS DOI 10.1021/acschemneuro.7b00107 
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rok CC IF IF Q (best) JCR Av Jour IF Perc SJR SJR Q (best) CiteScore N rok vydania rok metriky IF IF Q (best) SJR SJR Q (best) 2017 2016 3.883 Q1 1.538 Q1
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