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Synthesis and free radical scavenging activity of new hydroxybenzylidene hydrazines
Title Synthesis and free radical scavenging activity of new hydroxybenzylidene hydrazines Author info František Šeršeň ... [et al.] Author Šeršeň František (15%)
Co-authors Gregáň Fridrich 1944- (15%) UMBFP08 - Katedra chémie
Kotora Peter (10%)
Kmeťová Jarmila 1975- (20%) UMBFP08 - Katedra chémie
Filo Juraj (10%)
Loos Dušan (5%)
Gregáň Juraj (25%)
Source document Molecules. Vol. 22, no. 6 (2017), pp. 1-11. - Basel : Multidisciplinary Digital Publishing Institute, 2017 Keywords electrons derivatives Language English Country Switzerland systematics 54 Annotation Hydroxybenzylidene hydrazines exhibit a wide spectrum of biological activities. Here, we report synthesis and free radical scavenging activity of nine new N-(hydroxybenzylidene)-N'-[2,6-dinitro-4-(trifluoromethyl)]phenylhydrazines. The chemical structures of these compounds were confirmed by H-1-NMR, C-13-NMR, F-19-NMR, IR spectroscopy, LC-MS, and elemental analysis. The prepared compounds were tested for their activity to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR), and 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The free radical scavenging activity expressed as SC50 values of these compounds varied in a wide range, from a strong to no radical scavenging effect. The most effective radical scavengers were hydroxybenzylidene hydrazines containing three hydroxyl groups in the benzylidene part of their molecules. The prepared compounds were also tested for their activity to inhibit photosynthetic electron transport in spinach chloroplasts. IC50 values of these compounds varied in wide range, from an intermediate to no inhibitory effect. Public work category ADC No. of Archival Copy 40545 Repercussion category GUAN, Liping - PENG, Dingxin - ZHANG, Li - JIA, Jinjing - JIANG, Haiying. Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity. In Bioorganic and medicinal chemistry letters. ISSN 0960-894X, 2021, vol. 52, art. no. 128306, pp. 1-5.
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